Publications by authors named "Russell L Lewis"
Article Synopsis
- Cathepsin B (CtsB) is a protease linked to various health conditions and its absence in mice was examined to understand diabetic kidney disease induced by streptozotocin (STZ).
- Analysis of urinary extracellular vesicles (uEVs) revealed specific bioactive lipids associated with oxidative stress and renal cell death in CtsB knockout mice treated with STZ.
- Findings indicate that STZ treatment activates antioxidant responses in the kidneys but primarily leads to apoptosis (programmed cell death) rather than ferroptosis, highlighting key mechanisms in diabetic kidney disease development.
Lipids are a major class of molecules that play key roles in different biological processes. Understanding their biological roles and mechanisms remains analytically challenging due to their high isomeric content (e.g.
View Article and Find Full Text PDFThe undergraduate biochemistry laboratory curriculum is designed to provide students with experience in protein isolation and purification protocols as well as various data analysis techniques, which enhance the biochemistry lecture course and give students a broad range of tools upon which to build in graduate level laboratories or once they begin their careers. One of the most common biochemistry protein purification experiments is the isolation and characterization of cytochrome c. Students across the country purify cytochrome c, lysozyme, or some other well-known protein to learn these common purification techniques.
View Article and Find Full Text PDFBackground: Postoperative readmissions have been proposed by Medicare as a quality metric and can impact provider reimbursement. Because readmission after pancreatectomy is common, we sought to identify factors associated with readmission to establish a predictive risk scoring system.
Study Design: A retrospective analysis of 2,360 pancreatectomies performed at 9 high-volume pancreatic centers between 2005 and 2011 was performed.