Publications by authors named "Russel O Pieper"
Article Synopsis
- TERT promoter mutations are prevalent in wild-type IDH glioblastoma, making GABPB1 a potential therapeutic target, necessitating noninvasive imaging biomarkers for TERT modulation.
- The study utilized various glioblastoma models and magnetic resonance spectroscopy (MRS) to assess the effects of silencing TERT and GABPB1 on metabolic changes.
- Results indicated significant alterations in lactate and glutathione levels linked to TERT expression, suggesting these metabolites could be viable biomarkers for monitoring responses to TERT-targeted therapies in glioblastoma, with clinical implications for patient management.
To optimize the development of stem cell (SC)-based therapies for the treatment of glioblastoma (GBM), we compared the pathotropism of 2 SC sources, human mesenchymal stem cells (hMSCs) and fetal neural stem cells (fNSCs), toward 2 orthotopic GBM models, circumscribed U87vIII and highly infiltrative GBM26. High resolution and contrast-enhanced (CE) magnetic resonance imaging (MRI) were performed at 14.1 Tesla to longitudinally monitor the in vivo location of hMSCs and fNSCs labeled with the same amount of micron-size particles of iron oxide (MPIO).
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