Publications by authors named "Ruslan B Strutynskyi"
Upregulation of ATP-Sensitive Potassium Channels as the Potential Mechanism of Cardioprotection and Vasorelaxation Under the Action of Pyridoxal-5-Phosphate in Old Rats.
J Cardiovasc Pharmacol Ther
November 2023
Article Synopsis
- The study examines how aging affects protective mechanisms in the body, particularly focusing on ATP-sensitive potassium channels and their role in heart protection via pyridoxal-5-phosphate (PLP) treatment.
- Experiments were conducted on adult and aged rats to assess the impact of PLP on heart health, including mRNA and protein expressions of potassium channels, heart tissue morphology, and responses in cardiac function during stress tests.
- Results indicated that PLP treatment in older rats reduced heart fibrosis, improved heart function under stress, and increased the expression of specific potassium channel subunits while also reducing oxidative stress markers, suggesting a potential therapeutic benefit of PLP through enhanced potassium channel activity and production of protective substances.
ATP-sensitive potassium (K) channels are participants of mechanisms of pathological myocardial remodeling containment. The aim of our work was to find the association of changes in the expression of Kir6.1, Kir6.
View Article and Find Full Text PDFFluorine-containing pinacidil-derivative flocalin is an effective adenosine triphosphate-sensitive potassium (K(ATP))-channel opener with pronounced vasodilatory, cardioprotective effects and low general toxicity. By activating cardiac K(ATP) channels, flocalin hyperpolarizes cardiac myocytes, decreases their excitability, reduces Ca(2+) entry, and inhibits Ca(2+)-dependent signalling processes. Since our previous studies indicated that the drug also influences the rate of rise and amplitude of the cardiomyocyte's action potential, here we have investigated its possible actions on depolarizing inward currents through voltage-gated sodium (VGSC) and L-type calcium (VGCC) channels.
View Article and Find Full Text PDFBackground And Purpose: A class of drugs known as K(ATP) -channel openers induce cardioprotection. This study examined the effects of the novel K(ATP) -channel opener, the fluorine-containing pinacidil derivative, flocalin, on cardiac-specific K(ATP) -channels, excitability of native cardiac myocytes and on the ischaemic heart.
Experimental Approach: The action of flocalin was investigated on: (i) membrane currents through cardiac-specific K(ATP) -channels (I(KATP) ) formed by K(IR) 6.