Publications by authors named "Ruslan Al-Shekhadat"

Article Synopsis
  • The study evaluated the effectiveness of two specific antivenoms (Uzbiopharm® and Microgen®) against the venom from the Dagestan blunt-nosed viper using advanced methods like venomics and neutralization assays.
  • Despite having low concentrations of specific antibodies against venom toxins, both antivenoms were able to neutralize key toxic effects in mice, such as lethality and hemorrhaging.
  • The findings highlight the potential for these antivenoms to treat envenomings from Eurasian snakes and emphasize the importance of understanding their specificity for effective use.
View Article and Find Full Text PDF

We developed a candidate DNA vaccine called "DNA-4"consisting of 4 plasmid DNAs encoding Nef, Gag, Pol(rt), and gp140 HIV-1 proteins. The vaccine was found to be safe and immunogenic in a phase I clinical trial. Here we present the results of a phase II clinical trial of "DNA-4".

View Article and Find Full Text PDF

The common European adder, , is a medically relevant species, which is widely distributed in Russia and thus, is responsible for most snakebite accidents in Russia. We have investigated the toxic and enzymatic activities and have determined the proteomic composition of its venom. Phospholipases A (PLA₂, 25.

View Article and Find Full Text PDF

Background: Recombinant hemagglutinin (rHA) and neurominidase (rNA) developed in our investigation are amino acid sequence consensus variants of H1N1 2009 subtype influenza virus strain, also including immunogenic epitopes typical for other influenza virus subtypes (H3N1 and H5N1). Substitutions were made: typical for Russian virus isolates (in HA - S220T, NA - D248N) and in active centers of molecules - R118L, R293L, R368L; C92S, C417S to increase recombinant proteins stability in E. coli.

View Article and Find Full Text PDF

Microsporidia, a large group of fungi-related protozoa with an obligate intracellular lifestyle, are characterized by a drastically reduced cell machinery and a unique metabolism. These parasites possess genes encoding glycolysis components and glycerol-phosphate shuttle, but lack typical mitochondria, Krebs cycle, respiratory chain and pyruvate-converting enzymes, except for two subunits of the E(1) enzyme of the pyruvate dehydrogenase complex. This study demonstrates that in spite of the above, destroyed spores of the microsporidian Paranosema (Antonospora) grylli and P.

View Article and Find Full Text PDF