Modes of Interactions with DNA/HSA Biomolecules and Comparative Cytotoxic Studies of Newly Synthesized Mononuclear Zinc(II) and Heteronuclear Platinum(II)/Zinc(II) Complexes toward Colorectal Cancer Cells.

A series of mono- and heteronuclear platinum(II) and zinc(II) complexes with 4,4',4″-tri--butyl-2,2':6',2″-terpyridine ligand were synthesized and characterized. The DNA and protein binding properties of [ZnCl(terpy)] (), [{-PtCl(NH)(-pyrazine)ZnCl(terpy)}](ClO) (), [{-PtCl(NH)(-pyrazine)ZnCl(terpy)}](ClO) (), [{-PtCl(NH)(-4,4'-bipyridyl)ZnCl(terpy)}](CIO) () and [{-PtCl(NH)(-4,4'-bipyridyl)ZnCl(terpy)}](CIO) () (where terpy = 4,4',4″-tri--butyl-2,2':6',2″-terpyridine), were investigated by electronic absorption, fluorescence spectroscopic, and molecular docking methods. Complexes featuring transplatin exhibited lower and constant values compared to cisplatin analogs.