Publications by authors named "Rushlenne Pascual"
Background: Antimicrobial resistance (AMR) is a global threat to infectious disease control, particularly among recently hospitalized children. We sought to determine the prevalence and mitigating factors of resistance in enteric among children discharged from health facilities in western Kenya.
Methods: Between June 2016 and November 2019, children aged 1 to 59 months were enrolled at the point of discharge from the hospital.
Malaria transmission begins when infected female mosquitos deposit parasites into the mammalian host's skin during a bloodmeal. The salivary gland-resident sporozoite parasites migrate to the bloodstream, subsequently invading and replicating within hepatocytes. As mosquitos are more active at night, with a 24-hour rhythm, we investigated whether their salivary glands are under circadian control, anticipating bloodmeals and modulating sporozoite biology for host encounters.
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- Neisseria gonorrhoeae poses a significant public health risk due to rising cases and antimicrobial resistance, with whole-genome sequencing (WGS) evaluated for predicting susceptibility to various antimicrobials.
- 481 isolates from five countries were analyzed, revealing that susceptibility to ciprofloxacin is linked to a specific genetic marker (gyrA codon 91), while predicting susceptibility to other drugs requires a multilocus approach.
- All isolates tested were susceptible to zolifodacin, and while a single marker can guide ciprofloxacin treatment, a combination of markers is necessary for other medications.
Background: Rectal Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) are increasingly recognized as common infections among women. Little is known about the prevalence of rectal Mycoplasma genitalium (MG), rectal MG/CT/GC coinfection, or MG antimicrobial resistance patterns among women.
Methods: In 2017 to 2018, we recruited women at high risk for CT from Seattle's municipal sexually transmitted disease clinic.
Background: Rectal Chlamydia trachomatis (CT) is common among clinic-attending women, but little is known about clearance and health implications of rectal CT.
Methods: At the municipal sexually transmitted disease clinic in Seattle, Washington, in 2017-2018, we enrolled women at high risk for urogenital CT into an 8-week prospective study. Women received standard CT treatment at enrollment.