Photoacoustic image reconstruction with an objective function using TGV and ESTGV as a regularization functional.

Photoacoustic tomographic imaging is a non-invasive medical diagnostic technology for visualizing biological tissue. However, the inverse problem and noise in photoacoustic signals often cause blurred images. Existing regularization methods struggle with staircasing artifacts and edge preservation.

Gold nanorod embedded reduction responsive block copolymer micelle-triggered drug delivery combined with photothermal ablation for targeted cancer therapy.

Background: Gold nanorods, by virtue of surface plasmon resonance, convert incident light energy (NIR) into heat energy which induces hyperthermia. We designed unique, multifunctional, gold nanorod embedded block copolymer micelle loaded with GW627368X for targeted drug delivery and photothermal therapy.

Methods: Glutathione responsive diblock co-polymer was synthesized by RAFT process forming self-assembled micelle on gold nanorods prepared by seed mediated method and GW627368X was loaded on to the reduction responsive gold nanorod embedded micelle.

A partial reconstruction scheme for continuous wave diffuse optical tomography with reflection geometry.

Image quality and photon measurement with good SNR (signal to noise ratio) in continuous wave diffuse optical tomography depend on the source detector density and sensitivity of photo detector. For large volume objects, it is difficult to obtain detectable light intensity with good SNR over the whole boundary. As an alternative, instead of the full boundary, the measurements are taken over a semi circle as in reflection geometry and a partial reconstruction scheme for the same is proposed in this paper.

Contrast improvement of continuous wave diffuse optical tomography reconstruction by hybrid approach using least square and genetic algorithm.

Reconstruction of the absorption coefficient of tissue with good contrast is of key importance in functional diffuse optical imaging. A hybrid approach using model-based iterative image reconstruction and a genetic algorithm is proposed to enhance the contrast of the reconstructed image. The proposed method yields an observed contrast of 98.

Swept-source optical coherence tomography of lower limb wound healing with histopathological correlation.

Direct noninvasive visualization of wound bed with depth information is important to understand the tissue repair. We correlate skin swept-source-optical coherence tomography (OCT) with histopathological and immunohistochemical evaluation on traumatic lower limb wounds under honey dressing to compare and assess the tissue repair features acquired noninvasively and invasively. Analysis of optical biopsy identifies an uppermost brighter band for stratum corneum with region specific thickness (p < 0.