Pregnancy in Orthopaedic Residents: Peripartum Barriers Identified.

Unlabelled: While there are multiple barriers that may discourage women from choosing a career in orthopaedic surgery, one area of concern is pursuing pregnancy during residency training. This study's primary purpose was to determine the most prominent barriers to pursuing pregnancy during orthopaedic surgery residency.

Methods: A 63-item survey designed to evaluate multiple aspects of childbearing during orthopaedic surgery residency was distributed through email and a targeted Facebook platform to female orthopaedic surgeons and orthopaedic trainees in the United States.

Midterm Follow-up of a Novel Algorithm for Nonoperative Weber B Ankle Fractures.

Background: Stable Weber B ankle fractures are routinely treated nonoperatively. Our group previously presented a novel algorithm that provides radiographic parameters guiding when Weber B ankle fractures can be treated nonoperatively. The purpose of this study is to evaluate the durability of those results with a minimum 5-year follow-up.

Reliability, validity and treatment sensitivity of the Schizophrenia Cognition Rating Scale.

Cognitive functioning can be assessed with performance-based assessments such as neuropsychological tests and with interview-based assessments. Both assessment methods have the potential to assess whether treatments for schizophrenia improve clinically relevant aspects of cognitive impairment. However, little is known about the reliability, validity and treatment responsiveness of interview-based measures, especially in the context of clinical trials.

Development of a virtual reality assessment of everyday living skills.

Cognitive impairments affect the majority of patients with schizophrenia and these impairments predict poor long term psychosocial outcomes.  Treatment studies aimed at cognitive impairment in patients with schizophrenia not only require demonstration of improvements on cognitive tests, but also evidence that any cognitive changes lead to clinically meaningful improvements.  Measures of "functional capacity" index the extent to which individuals have the potential to perform skills required for real world functioning.

Alemtuzumab and sirolimus in renal transplantation: six-year results of a single-arm prospective pilot study.

mTOR inhibitors avoid calcineurin nephrotoxicity, but sirolimus de novo is associated with unacceptable side effects and higher rejection rates. We have investigated a modified strategy: alemtuzumab induction with tacrolimus and mycophenolate maintenance, switching from tacrolimus to sirolimus at 6 months and stopping mycophenolate at 12 months. Here, we report the 6-year follow-up of 30 patients prospectively recruited to this single-arm pilot study and compare outcomes to a matched contemporaneous control group of 30 patients who received standard induction and calcineurin-inhibitor-based immunosuppression.