Clonal dissemination of KPC-2-producing ST11 and ST48 clone among multiple departments in a tertiary teaching hospital in Jiangsu Province, China.

Background: The world-wide prevalence of carbapenem-resistant (CRKP) poses a threat to the public health. The objective of this study was to determine the epidemiological and molecular patterns of KPC-producing clinical isolates.

Methods: In this study, a total of 82 non-duplicated CRKP isolates were analyzed for the prevalence of resistant determinants including carbapenemase, extended spectrum β-lactamase (ESBLs), and AmpC as well as integrons and cassette regions by polymerase chain reaction (PCR) and DNA sequencing.

Dissemination of Multidrug-Resistant and with Class 1, Class 2, and Atypical Class 1 Integrons in China.

Emergence of multidrug-resistant , a major causative agent of bacterial dysentery, has generated many concerns not only in China but also worldwide. However, the prevalence of resistance caused by integron in the nonpopular season of diarrhea is not clear. Thirty-one and 22 samples collected in December 2010 from 10 cities of China were characterized for antimicrobial susceptibility, gene cassettes, widespread of integrons, and pulsed-field gel electrophoresis (PFGE) profile.

High Prevalence of Variants Among Carbapenem-Resistant in Northern Jiangsu Province, China.

The continuous emergence of carbapenem-resistant (CRECO) presents a great challenge to public health. New Delhi metallo-lactamase (NDM) variants are widely disseminated in China, so the research on the prevalence and transmission of diverse variants is urgently needed. In the present study, 54 CRECO isolates were collected from 1,185 isolates in five hospitals in Northern Jiangsu Province, China from September 2015 to August 2016.

Virulence-associated genes and molecular characteristics of non-O1/non-O139 Vibrio cholerae isolated from hepatitis B cirrhosis patients in China.

Objectives: We aimed to report virulence-associated genes and molecular characteristics of non-O1/non-O139 Vibrio cholerae isolated from hepatitis B cirrhosis patients in China.

Methods: Patient clinical data including course of disease, laboratory tests, antibiotic treatment and outcomes were collected. Antimicrobial susceptibility testing was performed and virulence-associated genes were detected by PCR.

The emerging problem of linezolid-resistant enterococci.

Enterococcus is a significant pathogen in numerous infections, particularly in nosocomial infections, and is thus a great challenge to clinicians. Linezolid (LNZ), an oxazolidinone antibiotic, is an important therapeutic option for infections caused by Gram-positive bacterial pathogens, especially vancomycin-resistant enterococci. A systematic review was performed of the available literature on LNZ-resistant enterococci (LRE) to characterise these infections with respect to epidemiological, microbiological and clinical features.

Novel mutations in gyrA and parC among Shigella sonnei strains from Jiangsu Province of China, 2002-2011.

Background: To investigate fluoroquinolone resistance and associated mechanisms of Shigella sonnei isolates in Jiangsu Province of China between 2002 and 2011.

Methods: All 337 unduplicated S. sonnei isolates were collected from hospitals in Jiangsu Province from January 2002 to December 2011.