The Impact of Abdominal Insufflation on the Intraocular Pressure During Robot-Assisted Radical Prostatectomy.

Increased intraocular pressure (IOP) during robot-assisted radical prostatectomy (RARP) is known to occur and may cause in rare cases anterior ischemic optic neuropathy. In this study, we evaluated the impact of abdominal insufflation pressures on IOP during RARP in a cohort of patients undergoing RARP. Patients undergoing RARP were recruited for this Institutional Review Board-approved study from January 2019 to October 2022 at our Center.

Probiotic characteristics and survival of a multi-strain lactic acid bacteria consortium in simulated gut model.

Dahi, a traditional yet underexplored fermented milk product from Pakistan, harbors diverse lactic acid bacteria (LAB) that have potential as probiotics. These bacteria could be used for therapeutic purposes, beneficial modulation of gut microbiota, and in the formulation of functional foods and feeds. This study aimed to isolate and characterize probiotic LAB from dahi, assess their survival in simulated gastrointestinal conditions, and evaluate their safety and probiotic potential, both phenotypically and genotypically.

Unraveling the genetic connections for mitochondrial DNA control region and breast cancer susceptibility.

Breast cancer, a complex global health concern, has predominantly been studied for nuclear DNA variations. However, the role of mitochondrial DNA (mtDNA) haplogroups in breast cancer susceptibility, especially in Pakistan, remains underexplored. This case-control study investigates the association between mtDNA haplogroups and breast cancer in Pakistan.

Catechin, taxifolin, and proanthocyanidin derivatives from Entada elephantina rhizome and their antimicrobial activity assessment.

Twenty-two compounds, predominantly catechin, taxifolin, and proanthocyanidin derivatives, were isolated and characterized from the methanol extract of Entada elephantina tuberous rhizomes. Five taxifolin-based metabolites, elephantinosides A-E (1-5) and one proanthocyanidin, elephantinoside F (19), were previously undescribed. Their structures were elucidated primarily based on 1D- and 2D-NMR and HRESIMS data.

Real-life observation of wildfire-smoke impaired COVID-19 vaccine immunity.

Background: Wildfires are increasingly common with wildfire smoke affecting millions globally, yet its impact on immune responses is poorly understood.

Objective: This real-world study, conducted on participants in the Pfizer BNT162b2 COVID-19 vaccine trial, studied the effects of wildfire smoke exposure on long-term vaccine immunity.

Methods: We recruited 52 healthy, non-smoking individuals (ages 26-83) who were either vaccinated (Group 1, n=28) or placebo injected (Group 2, n=24) during heavy wildfire smoke conditions.

Enhanced mechanical properties of cellulose fiber networks through synergistic effects of telechelic-structured carbohydrate-binding module-modified amphoteric polyacrylamide.

Mechanical integrity is a pivotal characteristic of cellulose fiber networks; however, their wet strength frequently deteriorates under humid conditions due to the hydrophilic nature of cellulose. This study presents a novel conjugate additive, synthesized by grafting carbohydrate-binding modules onto amphoteric polyacrylamide (CBM3-AmPAM), aimed at enhancing the mechanical properties of cellulose fiber networks at the wet-end of papermaking. The incorporation of CBM3-AmPAM significantly improved performance compared to AmPAM alone, with stress-strain properties enhanced by 1130.

Optimizing in vitro lung cancer therapy with folate-conjugated polydopamine-coated liposomes loaded with gemcitabine.

Purpose: Surface-altered, targeted nanocarriers play crucial roles in chemotherapy. Incorporating ligands into polymers may alter their chemical composition, potentially compromising their drug storage and encapsulation capacity. Polydopamine (PDA) is a novel, biocompatible, and versatile agent for producing targeted nanoparticles that serve as a base for conjugating specific ligands to non-reactive polymeric nanocarriers.

Effectiveness of Lower Range of High-intensity Statin Therapy in Lowering LDL-C among STEMI Patients.

Background: Lipid-lowering is an important intervention to reduce cardiovascular morbidity and mortality after ST-Elevation myocardial infarction. This study aimed to assess the proportion of such patients achieving guideline-directed therapeutic low-density lipoprotein cholesterol targets while on lower-range high-intensity statin treatment.

Methods: This is a cross-sectional study conducted in Shahid Gangalal National Heart Centre, a tertiary cardiac center in Kathmandu, Nepal, from November 2021 to July 2022 among admitted acute ST-Elevation myocardial infarction patients who were prescribed a lower range of high-intensity statin therapy, Atorvastatin 40mg and Rosuvastatin 20 mg.

Effect of polishing methods on Candida albicans adhesion and contributing factors in heat-cured acrylic dentures: an in-vitro comparative study.

Introduction: Heat-polymerized acrylic resin is widely used in prosthodontics due to its various advantages. However, its susceptibility to microbial colonization, influenced by surface properties such as roughness, water sorption, and free surface energy, poses challenges in maintaining oral health. Microbial adhesion, particularly of Candida albicans, plays a significant role in the overall microbial load on the denture surface, predisposing several oral and health related complications.

Maternal knowledge, attitude and practice regarding commercial oral rehydration salt solution: experience from a diarrhoeal disease hospital in Bangladesh.

Background: Despite oral rehydration salt (ORS) solution being a life-saving medication, mothers of affected children often lack proper knowledge and exhibit improper practice of using ORS in sachets. We aimed to assess maternal knowledge, attitude and practice towards commercially available ORS and its use in treating under-5 children with diarrhoea.

Methods: The study was conducted at the Dhaka Hospital, Bangladesh.

Comparative catalytic analysis of non-biodegradable barium oxide nanoparticles and biodegradable barium oxide/sodium alginate nanocomposite against organic dyes.

Novel-shaped non-biodegradable barium oxide nanoparticles (N-Bio-BaO NPs) were synthesized via the solvothermal method, while a biodegradable barium oxide/sodium alginate nanocomposite (Bio-BaO/Na-Alg NC) was prepared using simple composition process. Characterization techniques confirmed the successful synthesis of both materials. XRD revealed a highly crystalline monoclinic structure for N-Bio-BaO NPs compared to Bio-BaO/Na-Alg NC.

Modification of bacterial cellulose by MoBT MBene and 1,4-dithiothreitol for rapid and efficient adsorption of indomethacin and losartan potassium.

Lowering the threat of antibiotics is a hot issue in environmental chemistry. To overcome this problem, a novel MBene-based adsorbent, DTT@BC@MoBT, was designed by modification of bacterial cellulose (BC) using MoBT MBene and 1,4-dithiothreitol (DTT). Several characterization methods, including Fourier transforms infrared (FTIR), X-ray photoelectron spectroscopy (XPS), and X-ray Diffraction (XRD), confirmed the successful synthesis of DTT@BC@MoBT composite.

TMT-label comparative proteomics reveals the vernalization mechanism in Wucai (Brassica campestris L.).

To investigate the molecular basis of vernalization in Wucai [Brassica campestris L. (Syn. Brassica rapa L.

Novel evidence of arsenic-related excess adiposity and its implication in the risk of cardiometabolic diseases.

Arsenic exposure is associated with obesity- or excess adiposity-related disorders, including cardiometabolic diseases. Previously, many human studies attempted to establish the association of arsenic exposure with obesity, mainly through body mass index (BMI) but failed to provide any concrete evidence. Our study aimed to investigate the arsenic-related adiposity and its relationship with cardiometabolic diseases.

Intraoperative neurophysiology monitoring utilization in the USA during the period 2006-2022.

Objective: To describe the secular trends in utilization of intraoperative neurophysiology monitoring (IONM).

Methods: Retrospective descriptive study of a large claims database of privately-insured patients in the USA during the period 2006-2022.

Results: Among 3917 cerebellopontine angle tumor resections in 3779 patients [median (p-p) age: 49 (38-56) years, 59 % females], 910 (23.

Comprehensive Characterization and Bioactivity Assessment of Titanium Dioxide Nanoparticles Synthesized Using Chrysanthemum indicum Leaf Extract.

Bionanotechnology is the synthesis of environmentally friendly, biosynthetic nanomaterials by combining nanotechnology and biotechnology. Chrysanthemum indicum leaf extract in aqueous medium was used in the presented research work to produce titanium dioxide (TiO) nanoparticles using a dependable and environmentally friendly method. The TiO nanoparticles derived from C.

Gastrointestinal Subepithelial Lesions: Evolution in Management and Endoscopic Resection Techniques.

Purpose Of Review: Subepithelial lesions (SELs) are tumors originating from the gastrointestinal (GI) tract wall (muscularis mucosa, submucosa, or muscularis propria) and are covered by overlying mucosa. They are typically incidental findings during routine endoscopy. This article reviews the latest advancements in endoscopic techniques and devices used to resect subepithelial lesions.

The Role of Dietary Protein in Mitigating the Risk of Nonalcoholic Fatty Liver Disease.

Nonalcoholic fatty liver disease (NAFLD) is a prevalent liver disease, mainly associated with excessive accumulation of fat in the liver. It has become a global health concern. The diagnosis of NAFLD is often done through liver biopsy; however, noninvasive methods have their own advantages.

UK Medical Cannabis Registry: An Analysis of Clinical Outcomes of Medicinal Cannabis Therapy for Cancer Pain.

Cancer pain (CP) is a prevalent condition with limited pharmacotherapeutic options. Cannabis-based medicinal products (CBMPs) have shown analgesic effects, but their efficacy in CP remains contentious. This study aims to evaluate the change in patient-reported outcome measures (PROMs) and adverse events (AEs) in CP patients treated with CBMPs.

Transgenerational gut dysbiosis: Unveiling the dynamics of antibiotic resistance through mobile genetic elements from mothers to infants.

Objectives: The initial microbial colonization of the gut is seeded by microbes transmitted from the mother's gut, skin, and vaginal tract. As the gut microbiome evolves, a few transmitted microbes persist throughout life. Understanding the impact of mother-to-neonate gut microbiome and antibiotic resistance genes (ARGs) transmission is crucial for establishing its role in infants' immunity against pathogens.