Immunomodulatory and growth-promoting effects of root powder in broiler chicks challenged with Gallinarum.

Background: Amid growing concern about antimicrobial resistance due to the irrational use of antibiotics in treating common poultry diseases, particularly which is a foodborne pathogen in humans. This study investigates the effects of ethnoveterinary supplementation of (L. Benth.

Rescue of Iatrogenic Spiral Dissections Using an Intravascular Ultrasound-Guided Parallel Wire Technique.

Percutaneous coronary intervention carries a risk of iatrogenic catheter dissection. A spiral aorto-ostial dissection can completely occlude the vessel and cause ischemia with significant hemodynamic compromise. The mortality from such dissections is approximately 6.

Advanced wave dynamics in the STF-mBBM equation using fractional calculus.

In this article, we investigate the STF modified Benjamin-Bona-Mahony (STF-mBBM) equation, which is important in understanding wave phenomena across various technical scenarios such as ocean waves, acoustic gravity waves and cold plasma physics. We describe the fundamental properties of fractional calculus and its application to the STF-mBBM equation. Utilizing beta derivatives, we enhance our understanding of the intricate wave dynamics involved.

RNA methyltransferase SPOUT1/CENP-32 links mitotic spindle organization with the neurodevelopmental disorder SpADMiSS.

SPOUT1/CENP-32 encodes a putative SPOUT RNA methyltransferase previously identified as a mitotic chromosome associated protein. SPOUT1/CENP-32 depletion leads to centrosome detachment from the spindle poles and chromosome misalignment. Aided by gene matching platforms, here we identify 28 individuals with neurodevelopmental delays from 21 families with bi-allelic variants in SPOUT1/CENP-32 detected by exome/genome sequencing.

Metagenomic Analysis of Microbial Community Associated with Food Waste Composting.

Food waste is an increasing cause of concern in India. Its management through composting plays a vital role in managing the biodegradable fraction of municipal solid waste. However, the existing composting process has many challenges, such as the lack of optimum microenvironment and microbiome knowledge, which limits efficient outcomes.

Integrating alternative therapies in overcoming chemotherapy resistance in tumors.

Chemotherapy-resistant tumors present a significant challenge in oncology, often leading to treatment failures owing to mechanisms such as genetic mutations, drug efflux, altered metabolism, and adaptations within the tumor microenvironment. These factors limit the effectiveness of treatment and contribute to tumor resistance. This review highlights the role of alternative therapies aimed at overcoming resistance mechanisms.

Navigating nephropathy and nephrotoxicity: understanding pathophysiology unveiling clinical manifestations, and exploring treatment approaches.

Nephropathy and nephrotoxicity are significant causes of renal impairment, with both conditions contributing to a substantial global healthcare burden. Nephropathy encompasses a range of kidney diseases, including glomerulonephritis, diabetic nephropathy, hypertensive nephropathy, and polycystic kidney disease, each with distinct pathophysiological mechanisms and clinical manifestations. Nephrotoxicity, often induced by environmental toxins or medications, can lead to acute kidney injury (AKI) or chronic kidney disease (CKD) if not properly managed.

Mechanisms and attitudes in responsive healthcare for forced migrant communities: a qualitative study of transnational practice.

Objectives: To understand the opportunities and practices that can support responsive healthcare for forced migrant communities.

Design: A qualitative study of five transnational case examples of services actively working to improve access and experiences of care for forced migrant communities, which is one strand of the MORRA Study.

Setting: Five services (Australia, Belgium, UK) providing a range of care (primary care, health advocacy, education and support, holistic health screening, care planning/coordination, transcultural mental healthcare).

Surgical management of neuromuscular scoliosis in paediatric patients: experiences from a tertiary centre multidisciplinary team.

Background: Management of neuromuscular scoliosis (NMS) is challenging, with both surgical and conservative options involving risks. This study aimed to evaluate multimorbidity in patients with NMS and how this influences multidisciplinary team (MDT) decisions as well as postoperative outcomes.

Methods: A retrospective cohort study of patients referred for assessment by the scoliosis MDT in the 8-year period between 2013 and 2021 from a single tertiary centre.

Cardiac stress in a child with perioperative anaphylaxis.

A case of cardiac stress following a grade 4 perioperative anaphylaxis was identified. We speculate that this may be a case of Kounis or adrenaline, takotsubo, anaphylaxis and Kounis (ATAK) complex. This is the first such case reported from the UK.

Evolving strategies for osteoporosis management in postmenopausal women: From tradition to innovation.

Osteoporosis is a chronic condition primarily affecting postmenopausal women, significantly impacting their well-being and quality of life. Traditional treatment approaches include medications, vitamins, and exercise, but there is a growing interest in alternative therapies that enhance bone health. This review was conducted by searching multiple databases, including PubMed, Medline, and Google Scholar, for studies related to osteoporosis treatment.

X-Linked Hypophosphatemia Management in Children: An International Working Group Clinical Practice Guideline.

Background: An International Working Group (IWG) developed new guidelines on the diagnosis, evaluation, management, and monitoring of X-linked hypophosphatemia (XLH) in children. Over the past 5 years, important advances have occurred in our understanding of the presentation, complications and treatment of XLH.

Methods: A group of 50 international experts in XLH from Canada, the United States, Europe, Asia and South America, along with methodology experts and patient partners, held 18 teleconference meetings in 2023-2024.

Evaluation of Surface Disinfection Efficiency of Vinegar and Asafoetida.

Background: Contaminated surfaces play a crucial role in transmitting infectious diseases. Effective surface disinfection is essential for interrupting disease transmission by eliminating pathogens on these surfaces. While traditional chemical disinfectants are effective, they pose significant health and environmental concerns, prompting the search for natural alternatives.

Early Feeding After Free Flap Reconstruction for Oral Cavity Cancer: A Single Institution Retrospective Review.

Objective: Patients undergoing free flap reconstruction of the oral cavity have traditionally received nothing by mouth for 6-14 days postoperatively to limit the risk of wound complications. Growing evidence suggests that initiation of oral intake may not increase the morbidity. This study further investigates the utility of "early feeding.

Sustainable machining of Inconel 718 using minimum quantity lubrication: Artificial intelligence-based process modelling.

Governments and industries are developing aggressive policies to reduce carbon emissions and shift from fossil fuels to renewable energy. On the other hand, industries struggle to reduce energy consumption and depend on production lot sizes to control energy requirements. In this regard, energy-efficient processing through CNC machine tools can potentially influence energy demand and requires energy-aware power consumption strategies for machining processes.

Effectiveness of chain of survival for out-of-hospital-cardiac-arrest (OHCA) in resource limited countries: A systematic review.

Aim: Given the critical disparities in survival for out-of-hospital-cardiac-arrest (OHCA) in resource limited countries and the lack of context-specific evidence to guide resuscitation practices, we aimed to systematically evaluate the effectiveness of the chain of survival components including bystander response, emergency medical services (EMS) response, advanced life support, and post-resuscitation care on outcomes such as return of spontaneous circulation, survival to admission, survival to hospital discharge, and neurological outcomes in these settings.

Methods: This systematic review, following PRISMA guidelines, included observational and interventional studies on OHCA management from low, lower-middle, and upper-middle-income countries, published in English (2004-2023). PubMed, Embase, CINAHL, and Cochrane Library were searched using predefined terms.

The impact of dimethylaminohexadecyl methacrylates on the physical and antibacterial properties of endodontic sealers.

Objective: This study aims to incorporate contact-killing quaternary ammonium into two root canal sealers, AH Plus (DentSply Sirona, New York City, NY, USA) and BC (FKG, Le Crêt-du-Locle Switzerland) sealers to improve their antibacterial properties.

Methods: Dimethylaminohexadecyl Methacrylates (DMAHDM) were synthesized and incorporated into AH Plus and BC sealers at 5 weight percent (wt.%).

Reducing physical assaults on residents through implementation of project BETA: Best practices in the evaluation and treatment of agitation.

Background And Objectives: We created a multitude of initiatives that were in line with the principles of the BETA (Best Practices in the Evaluation and Treatment of Agitation) guidelines to determine if these initiatives would reduce the physical assault rate by patients on emergency medicine (EM) residents.

Methods: We conducted three cross-sectional surveys of our EM residents (PGY-1 to -3) to determine the incidence of physical assaults by agitated patients at a large county hospital emergency department. These were primarily anonymous REDCap surveys and were administered at the following intervals: (1) pre-BETA initiative implementation, (2) approximately 12 months after implementation, and (3) 5 years postimplementation.

Hepatoprotective effect of decoction against paracetamol-induced toxicity: , and studies.

Objective: We aimed to investigate the pharmacologic mechanism underlying this traditional remedy.

Method: We used a freshly produced hot water decoction of leaves (HWDJS) to examine its hepatoprotective effects in laboratory animals, administering doses of HWDJS at 100, 200, and 300 mg/kg over 7 days. On the 8th day, paracetamol toxicity was induced at a dose of 2 g/kg.

Polarization Spin Inversion with Nonlinear Plasmon Scattering.

We report on circularly polarized Gaussian beam spin angular momenta that can be inverted upon scattering with quadrupole plasmon modes. The conditions for such conversion are met with high-angle collection, dark-field scattering microscopy on spherical plasmonic particles. We further report that silvered nanoporous silica microparticles exhibit a strong nonlinearity in their scattering, specifically a reverse saturated scattering (RSS), when exposed to high laser power densities on the sample of ca.

Repurposing doxycycline for the inhibition of monkeypox virus DNA polymerase: a comprehensive computational study.

Unlabelled: The global spread of monkeypox, caused by the double-stranded DNA monkeypox virus (MPXV), has underscored the urgent need for effective antiviral treatments. In this study, we aim to identify a potent inhibitor for MPXV DNA polymerase (DNAP), a critical enzyme in the virus replication process. Using a computational drug repurposing approach, we performed a virtual screening of 1615 FDA-approved drugs based on drug-likeness and molecular docking against DNAP.

On-site ERCP availability and cholangitis outcomes: Retrospective cohort study.

Background And Study Aims: Endoscopic retrograde cholangiopancreatography (ERCP) is important in acute cholangitis (AC) management but is not available at all hospitals. The association between on-site ERCP availability and cholangitis outcomes is unknown.

Patients And Methods: We included adults diagnosed with AC at 27 hospitals in Ontario through the GEMINI network.