Publications by authors named "Rupkatha Mukhopadhayay"
Article Synopsis
- Visceral leishmaniasis (VL), caused by the Leishmania donovani (LD) parasite, has seen increasing resistance to traditional treatments, notably pentavalent antimonials, leading to a resurgence of aggressive infections.
- The resistance mechanisms involve the upregulation of certain cytokines, like IL-10, resulting in the failure of antimonial drugs due to multidrug resistant proteins in infected cells.
- Alterations in microRNA profiles in macrophages during infection affect the balance of pro- and anti-inflammatory cytokines, suggesting that targeting the miRNA pathway could provide new therapeutic strategies against LD infections.
