Publications by authors named "Rupesh Kanhere"
Article Synopsis
- PI3Kδ inhibitors are used to treat B-cell malignancies, but existing options have limitations in potency, selectivity, and pharmacokinetics.
- Researchers developed a new inhibitor by improving the structure of an existing compound, transitioning from a "three-blade propeller" to a "four-blade propeller" design.
- The new compound shows superior effectiveness, selectivity, and stability, making it a promising candidate for treatment in various B-cell cancers, either alone or with other drugs.
Purpose: Aldesleukin, recombinant human IL2, is an effective immunotherapy for metastatic melanoma and renal cancer, with durable responses in approximately 10% of patients; however, severe side effects limit maximal dosing and thus the number of patients able to receive treatment and potential cure. NKTR-214 is a prodrug of conjugated IL2, retaining the same amino acid sequence as aldesleukin. The IL2 core is conjugated to 6 releasable polyethylene glycol (PEG) chains.
View Article and Find Full Text PDFAim: To evaluate the antifertility activity of Artemisia vulgaris leaves on female Wistar rats.
Method: The plant extract was tested for its effect on implant formation at two dose levels, 300 and 600 mg·kg⁻¹, respectively. The effective methanolic plant extract was further studied for estrogenic potency on ovariectomised immature female Wistar rats.
Context: The plant Hygrophila auriculata (K. Schum) Heine. (Acanthaceae) is widely used in the Indian System of Medicine as "Rasayana" for treating brain and liver diseases.
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