Pityrosporum ovale/orbiculare in papillomatous nevus cell nevi.

62% of 200 papillomatous nevus cell nevi compared to 45% of 40 seborrheic keratoses showed the presence of Pityrosporum ovale/orbiculare (Malassezia furfur) on their surface, supposedly representing a saprophytic state of the microorganisms in vivo. The papillomatous nevus cell nevi were of the compound or dermal type. Significant inflammation, dysplasia or major changes in color were absent.

[Panniculitis with liquefaction--a special manifestation of Pfeiffer-Weber-Christian panniculitis].

A case of nodular panniculitis with liquefaction in a 58-year-old woman patient is reported. It seems that Pfeiffer-Weber-Christian disease and nodular panniculitis with liquefaction are varying expressions of the same disease entity. The relationship to cases reported in the literature is discussed.

[Argyria. A clinical, chemical analytic and micromorphologic study].

A 62-year-old male patient developed generalized argyria following the intake of silver-proteinacetyltannate (Targesin; approx. 60 g in 10 years) as treatment for gastric discomfort. On histological and ultrastructural examination of the skin, silver particles were found not only in the usual locations but also in the Schwann cell, the mast cell, and in smooth muscle cells.

[Erythrodermic sarcoidosis (a clinical, light and electron microscopy study)].

We report on a 50-year-old patient suffering from erythrodermic sarcoidosis accompanied by visible enlargement of the peripheric lymph nodes. Histologic examination revealed epithelioid granulomas in the skin, in a lymph node, and in a liver biopsy. Ultrastructurally, we found a focal presence of cells with Langerhans' granules sometimes in a spatial relation to lymphoid cells within the corial granulomas.

[Pseudoangiosarcoma (Masson). A histological study (author's transl)].

The following is a report about two cases of pseudoangiosarcoma (Masson). The pseudoangiosarcomatous changes developed in one case in a cavernous hemangioma and in the other on the heel, presumably in the lumen of a vessel of the dermis. In our opinion thrombosis precedes the pseudoangiosarcomatous proliferation, which can be interpreted as a manifestation of a peculiar form of the organization of thrombotic material.

[Ultrastructure of adipose cells].

This report presents an ultrastructural study of normal subcutaneous fatty tissue. From well-know morphological facts on human adipocytes in adults we have been able to make the following additional observations: (a) Several lipid droplets were surrounded by a well-developed system of filaments; (b) material very similar (the same electron-density) to the central lipid droplet appeared within the smooth surfaced cisterns of the endoplasmatic reticulum; (c) complex lipid granules very probably corresponding to lipofuscin were present in the cytoplasm; (d) in the nuclei, often sphaeridia of the filamentous type appeared; (e) the quantity of so-called lipomicrons (electron-dense granules) is dependent on the method of fixation.

[On the question of cutaneous changes associated with paraproteinemia. Light- and electron-microscopic study (author's transl)].

This report deals with a case of paraproteinemia (IgG Kappa) associated with skin indurations and yellowish papules on the trunk, edema of the face, and crystals in the cornea. In addition to the absence of elastic fibers and reductions of collagen fibers, light microscopy revealed single and/or multinucleated dermal cells with slight streaky patterning of the cytoplasm. These cells contained some sudanophilic (the greatest quantities of sudanophilic substances were observed in the deep corium) and partly birefringent material.

[Juvenile melanoma; a clinical and histological study].

Investigations were carried out in 52 female and 18 male patients, aged between 2 and 49 years, with juvenile melanoma. The tumor occured as a solitary tumor in all cases except one. It was mainly localized on the head (54%), and the extremities, on the trunk in three cases only.

[The ultrastructure and acid phosphatase activity in the sweat glands with "clear, reticulated cytoplasm" (author's transl)].

Investigations were carried out on the ultrastructure and distribution of acid phosphatase in the human sweat glands with "clear, reticulated cytoplasm". It is probable that the gland cells with vacuolized cytoplasm develop from the serous gland cells through a morphologically recognizable intermediate state. An extralysosomal activity of acid phosphatase occurs in the vacuolized gland cells.

[Histochemical and ultrastructural study of cytochrome-oxydase in basal cell epithelioma].

The activity of cytochrome-oxydase is less pronounced in the basal cell epithelioma than in the basal cells of the surrounding normal epidermis. The electron microscopic study of the localisation of the enzyme reveals that the cells of the basal cell epithelioma contain two types of mitochondria, the first of which having the same size as the epidermal mitochondria, and the other being giant mitochondria. The latter seem to be less active.

On the occurrence of sphaeridia in basalioma cells and the basal cells of the overlying epidermis.

302 nuclear sections of basalioma cells, 145 nuclear sections of the basal cells of the epidermis above the tumor, and 177 nuclear sections of the basal cells of normal epidermis were investigated and statistically evaluated with the aim of determining the presence of sphaeridia occur significantly more frequently in the basal cells of the epidermis above the tumor and in normal epidermis than in the tumor itself. These findings are discussed in connection with the degree of cellular protein synthesis.

[Ultrastructure of solid basalioma. A morphometric study (author's transl.)].

A morphometric investigation was made on mitochondria of basalioma cells and the cells of the basal layer of the epidermis lying over the tumor. The mitochondria of the basalioma cells occupy 4.7% and of the epidermal basal cells 5.

[Hydrotherapy in cauterization wounds. A histologic study (author's transl)].

Investigations have have been carried out in guinea pigs to test the usefullness of hydrotherapy. Concentrated sulfuric acid was applied to the skin for a period of 30 sec and 5 min. After this the skin was washed with tap water for 1 hr.