Publications by authors named "Rupak D MukherJee"
Objective: Staged aortic aneurysm repair is one method used to decrease the risk of spinal cord ischemia (SCI) following endovascular aortic intervention. Sequential sacrifice of arteries perfusing the spine may allow for improved spinal perfusion through the development of collateral networks over time. To evaluate the impact of staging endovascular aortic aneurysm repairs on SCI, we conducted a conservative analysis of Vascular Quality Initiative (VQI) data.
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- Recent studies on epicardial derived cells (EPDCs) using mouse models show they play a significant role in the formation of structures at the atrioventricular (AV) junction, including the AV sulcus, annulus fibrosus, and AV valve leaflets.
- The specific mechanisms of how EPDCs contribute to these tissues and the role of bone morphogenetic protein (Bmp) signaling, particularly through its receptor Alk3, have not been well understood.
- Research revealed that deleting the Alk3 receptor in epicardial cells leads to underdeveloped AV structures and reduced EPDC presence in valve leaflets, highlighting Alk3-mediated Bmp signaling as crucial for both the early development and maturation of AV tissues