The aim of this study was to investigate the impact of the antibiotic lidamycin (LDM) and the targeted therapy with the antibody Myosin heavy chain 9 (MYH9) on cancer cells, aiming to provide insights for cancer treatment. In this study, antibiotics and targeted antibodies were used in cancer cells, and then their effects on cell growth, proliferation, apoptosis regulation, and related proteins were measured, and comparative analysis was conducted on the effects of different drug concentrations on the growth of cancer cells. In H460, the apoptotic effect of 2 nM LDM on cells reached 70%.
View Article and Find Full Text PDFBackground: Gastrointestinal cancer poses a considerable global health risk, encompassing a heterogeneous spectrum of malignancies that afflict the gastrointestinal tract. It is significant to develop efficacious therapeutic agents, as they are indispensable for both the treatment and prevention of this formidable disease.
Methods: In this study, we synthesized a novel thiophene derivative, designated as compound 1312.
Background: Gastric intestinal metaplasia (GIM) is an essential precancerous lesion. Although the reversal of GIM is challenging, it potentially brings a state-to-art strategy for gastric cancer therapeutics (GC). The lack of the appropriate in vitro model limits studies of GIM pathogenesis, which is the issue this work aims to address for further studies.
View Article and Find Full Text PDFHum Vaccin Immunother
August 2023
Affordable, polyvalent meningococcal vaccines are needed for use in emergency reactive immunization campaigns. A phase IV randomized, observer-blind, controlled study compared the safety and immunogenicity of a quadrivalent meningococcal polysaccharide vaccine (MPV-4, MPV ACYW135) and quadrivalent meningococcal ACWY conjugate vaccine (MCV-4, Menactra®). Healthy, 2- to 10-year-old children in Bamako, Mali, were randomized 1:1 to receive one dose of MPV-4 or MCV-4.
View Article and Find Full Text PDFRare earth elements (REEs) are widely used in high-tech industries, and REE waste emissions have become a concern for ecosystems, food quality and human beings. Arbuscular mycorrhizal fungi (AMF) have repeatedly been reported to alleviate plant stress in metal-contaminated soils. To date, little information is available concerning the role of AMF in REE-contaminated soils.
View Article and Find Full Text PDFBackground: Breast cancer is a common tumor in China and has become a public health problem in modern society. Stress plays an important role in the occurrence and progression of cancer. At present, the current situation of stress on breast cancer survivors (BCSs) in China has not been fully understood.
View Article and Find Full Text PDFRare earth elements including samarium have been widely used in modern technologies in recent decades. Following over-exploitation and soil contamination, they can accumulate in plants and be toxic at high concentrations. Arbuscular mycorrhizae benefit plants in metal-contaminated soils by improving their survival and growth and alleviating metal toxicity, but little information is available about soil contaminated by rare earth elements.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
December 2020
Rare earth elements (REEs) have been widely used in recent decades, and their exploitation has led to industrial REE emission and to contaminated soils especially in former mining areas. This raised people concerns on the accumulation and toxicity of REEs in soils and plants, and consequences on plant health. Although many studies dealt with REE in soils and plants, there is still a need to precise their toxicity, bioavailability and transfer to plants in contaminated sites in order to restore such ecosystems.
View Article and Find Full Text PDFBackground: Exosomes derived from mesenchymal stem cells (MSC-exos) have been demonstrated with great potential in the treatment of multiple human diseases including acute kidney injury (AKI) by virtue of their intrinsic cargoes. However, there are major challenges of low yield and the lack of an established biomanufacturing platform to efficiently produce MSC-exos, thereby limiting their therapeutic application. Here, we aimed to establish a novel strategy to produce MSC-exos with a hollow fiber bioreactor-based three-dimensional (3D) culture system and evaluate the therapeutic efficacy of 3D-exosomes (3D-exos) on AKI.
View Article and Find Full Text PDFArch Environ Contam Toxicol
April 2020
Volatile organic compounds (VOCs) are involved in the formation of ozone formation, which plays a significant role in regional air contamination and poses a great threat to human health. The VOCs were collected from the urban area of Hefei city via an off-line sampling method (SUMMA canister) and determined by gas chromatography-mass spectrometer. The average concentrations of VOCs were 17.
View Article and Find Full Text PDFDust on air conditioning filters can represent the re-suspended particulate matter in indoor air, which may pose potential health risks to humans. However, source identification and influence factors of indoor dust are controversial. The present study investigated the distribution of Cd, Cr, Mn, Ni, Pb, Sb, V, and Zn, as well as stable carbon isotope, in indoor dust from three different functional zones in Hefei to discuss the sources and influence factors of indoor dust.
View Article and Find Full Text PDFMetals in indoor dust pose potential health risks to humans. Dust deposition on air conditioner filters can represent the resuspended particulate matter in indoor air. However, few studies have examined this until now.
View Article and Find Full Text PDFAtmospheric particulates were sampled in Hefei City, China from October 2016 to January 2017 to compare chemical compositions and sources of PM (particle size smaller than 2.5 μm) and PM (particle size smaller than 10 μm). The mean levels of PM and PM were 81 and 109 μg/m, which are higher than the health threshold levels regulated by national and international standards.
View Article and Find Full Text PDFPlatinum (Pt) is considered a Technology Critical Element (TCE) and an emerging metallic contaminant with increasing release into the environment. Gaps in knowledge and understanding of environmental levels, fate and effects of Pt still exist, especially in the marine environment. This work presents Pt concentrations in the northwestern Mediterranean coast including: (i) temporal variability from sediment cores and farmed mussels in the Toulon Bay (historically affected by intense human activities) and (ii) spatial distribution from recent wild mussels collected along ∼ 700 km coastline with contrasting ecosystems (including natural reserves), quantified using voltammetry and inductively coupled plasma-mass spectrometry.
View Article and Find Full Text PDFThis conference report describes the training activities that took place in the frame of the Integrated in Situ Chemical MApping probe (SCHeMA) summer school organized from the 14th to the 16th of June 2016 in Bilbao (Spain).
View Article and Find Full Text PDFThe aim of the present study was to investigate the effect and the underlying mechanism of activated protein C (APC) in lipopolysaccharide (LPS) induced lung injury, as well as the potential mechanism. According to the treatment, 50 rats were randomly divided into 5 groups: Control, model (LPS), low-dose group [LPS + 0.1 mg/kg recombined human activated protein C (rhAPC)], median-dose group (LPS + 0.
View Article and Find Full Text PDFEcotoxicol Environ Saf
September 2018
In order to study the characteristics and health risk of VOCs in the ambient air in the typical developing cities in China, the research was conducted in five functional zones in Hefei from September 2016 to January 2017. The average concentrations of total measured VOCs in traffic zone was the largest (85.94 μg m), followed by industrial zone (64.
View Article and Find Full Text PDFBull Environ Contam Toxicol
February 2018
The characteristics of atmospheric PM- and PM-bound polycyclic aromatic hydrocarbons (PAHs) were investigated in Tongling city, China. Results showed that the total concentrations of PM- and PM-bound PAHs exhibited distinct seasonal and spatial variability. The metallurgic sites showed the highest PAH concentrations, which is mainly attributed to the metallurgic activities (mainly copper ore smelting) and coal combustion as the smelting fuel.
View Article and Find Full Text PDFAirborne PM2.5 and PM10 samples were collected in summertime (August 2015) and wintertime (December 2015-January 2016) in an industrial complex area in Hefei, China. The average concentrations of PM2.
View Article and Find Full Text PDFPlatinum Group Elements (PGEs) are extremely scarce in the Earth's Crust and of strong interest for high-end technologies due to their specific properties. They belong to the Technology Critical Elements (TCEs) for which use is forecast to increase, implying growing emissions into the environment in the following years. In particular, with the intensive use of platinum (Pt) in car catalytic converters, the anthropogenic geochemical cycle of this element has surpassed the natural cycle.
View Article and Find Full Text PDFBull Environ Contam Toxicol
February 2017
This work studied the concentrations and sources of polycyclic aromatic hydrocarbons (PAHs) in air-borne particulate matter of Hefei, China. Samples of PM were collected daily at two sites during May, 2014, and January, 2015. The average daily concentration of PM was 96.
View Article and Find Full Text PDFZhongguo Yi Xue Ke Xue Yuan Xue Bao
February 2016
Objective: To isolate, culture, and identify bone marrow mesenchymal stem cells (BMSCs) from enhanced green fluorescent protein (EGFP)-transgenic rats in vitro.
Methods: Bone marrows were isolated from tibia and femur of healthy EGFP-transgenic rats of specific pathogen free (SPF) grade. Then,the whole bone marrow adherent method was used for isolation,culture,and purification of BMSCs.
Introduction: Accumulating evidences have indicted the participation and repairing effects of endothelial progenitor cells (EPCs) on acute lung injury (ALI). Researchers have also revealed that erythropoietin (EPO) may exert multiple effects on EPCs including proliferative and adhesive properties. The present study was designed to investigate whether EPO can promote the healing efficiency of transplanted EPCs against ALI and the potential mechanism.
View Article and Find Full Text PDFMounting evidence suggests that transplanting endothelial progenitor cells (EPCs) into the myocardium improves cardiac function after myocardial infarction (MI). However, the mechanism remains controversial. The aim of this study was to investigate the role played by the VEGF- PI3K/Akt-eNOS pathway in EPC-based cell therapy.
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