Publications by authors named "Ruoyi Shen"
Article Synopsis
- - Acute respiratory distress syndrome (ARDS) is a serious condition characterized by severe lung inflammation and fluid buildup, leading to high risks of illness and death; it can be triggered by various factors and has complex underlying mechanisms involving immune responses and metabolism.
- - A genome-wide association study (GWAS) analyzed genetic data from 375 ARDS patients and over 400,000 controls, using Mendelian randomization to identify 8 specific lipid species linked to ARDS, including different types of cholesterol and phosphatidylcholines.
- - The study highlights how advanced genetic analysis can uncover connections between ARDS and lipid metabolism, suggesting that certain lipid profiles, influenced by immune cell activity, might play a role in the disease's development.
Background: Despite the increasing availability of therapeutic drugs for autoimmune diseases, many patients still struggle to achieve their treatment goals. Our aim was to identify whether drugs originally used to treat bone density could be applied to the treatment of autoimmune diseases through Mendelian randomization (MR).
Methods: Using summary statistics from genome-wide association studies, we used a two-sample MR design to estimate the correlation between autoimmune diseases and BMD-related drug targets.
Background: Allergic rhinitis (AR) is a pervasive global health issue, and currently, there is a scarcity of targeted drug therapies available. This study aims to identify potential druggable target genes for AR using Mendelian randomization (MR) analysis.
Methods: MR analysis was conducted to assess the causal effect of expression quantitative trait loci (eQTL) in the blood on AR.
Long intergenic nonprotein coding RNA 518 (LINC00518) is recognized to impart cancer proliferation and metastasis in lung adenocarcinoma (LUAD). However, the study about the relationship between LINC00518 and LUAD is shallow so far. In our work, LINC00518 was predicted to be a negative regulator in LUAD based on the TCGA database.
View Article and Find Full Text PDFConstruction of a Prognostic Immune-Related LncRNA Risk Model for Lung Adenocarcinoma.
Front Cell Dev Biol
March 2021
Background: Lung adenocarcinoma (LUAD) originates mainly from the mucous epithelium and glandular epithelium of the bronchi. It is the most common pathologic subtype of non-small cell lung cancer (NSCLC). At present, there is still a lack of clear criteria to predict the efficacy of immunotherapy.
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