Publications by authors named "Ruoyi Lin"
Objectives: To detect the plasma polyunsaturated fatty acids (PUFAs) concentrations in age-related macular degeneration (AMD) patients and healthy controls. Additionally, advanced studies were conducted to investigate the relationship between PUFAs concentrations and ophthalmological characteristics, including hyperreflective foci (HRF), visual acuity, and anti-vascular endothelial growth factor (anti-VEGF) response in patients with AMD.
Methods: This prospective, single-site study recruited a total of 315 participants, consisting of 105 individuals with dry AMD (early-stage AMD group), 105 individuals with neovascular AMD (late-stage AMD group), and 105 elderly individuals without any fundus diseases (healthy controls).
Background: Malignant mesothelioma is a type of infrequent tumor that is substantially related to asbestos exposure and has a terrible prognosis. We tried to produce a fibroblast differentiation-related gene set for creating a novel classification and prognostic prediction model of MESO.
Method: Three databases, including NCBI-GEO, TCGA, and MET-500, separately provide single-cell RNA sequencing data, bulk RNA sequencing profiles of MESO, and RNA sequencing information on bone metastatic tumors.
Pathological neovascularization is a pivotal biological process in wet age-related macular degeneration (AMD), retinopathy of prematurity (ROP) and proliferative diabetic retinopathy (PDR), in which macrophages (Mφs) play a key role. Tip cell specialization is critical in angiogenesis; however, its interconnection with the surrounding immune environment remains unclear. Succinate is an intermediate in the tricarboxylic acid (TCA) cycle and was significantly elevated in patients with wet AMD by metabolomics.
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- Cysteine-rich transmembrane module (CYSTM) proteins are important across various organisms including plants, where they contribute to growth, development, and stress responses.
- This study identified the CrCYSTM family in Canavalia rosea, a salt-tolerant plant, and explored their expression and functions regarding development and stress resistance.
- Findings suggest that different CrCYSTM members have unique roles in stress tolerance, particularly in heavy metal detoxification, setting the stage for further research on their functions in plant adaptation.
Gliomas including astrocytomas, oligodendrogliomas, mixed oligoastrocytic, and mixed glioneuronal tumors are an important group of brain tumors. Based on the 2016 WHO classification for tumors in the central nervous system, gliomas were classified into four grades, from I to IV, and brain lower grade glioma (LGG) consists of grade II and grade III. Patients with LGG may undergo recurrence, which makes clinical treatment tough.
View Article and Find Full Text PDFThe role of NAD metabolism in macrophages in age-related macular degeneration.
Mech Ageing Dev
January 2023
Age-related macular degeneration (AMD) is a leading cause of legal blindness and moderate and severe vision impairment (MSVI) in people older than 50 years. It is classified in various stages including early, intermediate, and late stage. In the early stages, innate immune system, especially macrophages, play an essential part in disease onset and progression.
View Article and Find Full Text PDFTetraspanins (TSPANs) are a class of four-transmembrane segmented proteins. The precise functions of TSPANs and their roles in pan-cancer are unclear. In this work, we analyzed TSPAN1, TSPAN10, TSPAN11, TSPAN12, TSPAN13, TSPAN14, TSPAN15, TSPAN16, TSPAN17, TSPAN18, TSPAN18-AS1, TSPAN19, TSPAN2, TSPAN3, TSPAN31, TSPAN32, TSPAN33, TSPAN4, TSPAN5, TSPAN6, TSPAN7, TSPAN8, TSPAN9, TSPAN9-IT1 (24 TSPAN family genes) in relation to tumor characteristics from 11,057 TCGA samples across 33 cancer types.
View Article and Find Full Text PDFBackground: We planned to uncover the cancer stemness-related genes (SRGs) in prostate cancer (PCa) and its underlying mechanism in PCa metastasis.
Methods: We acquired the RNA-seq data of 406 patients with PCa from the TCGA database. Based on the mRNA stemness index (mRNAsi) calculated by one-class logistic regression (OCLR) algorithm, SRGs in PCa were extracted by WGCNA.
Mesothelioma (MESO) is a mesothelial originate neoplasm with high morbidity and mortality. Despite advancement in technology, early diagnosis still lacks effectivity and is full of pitfalls. Approaches of cancer diagnosis and therapy utilizing immune biomarkers and transcription factors (TFs) have attracted more and more attention.
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- The study focuses on the genetic analysis of a halophyte plant found in tropical and subtropical coastal areas, which is known for its ability to thrive in high salinity and drought conditions.
- Researchers identified eight sodium/hydrogen (Na/H) exchanger genes in the plant's genome, which are crucial for ion transport and salinity tolerance.
- Expression analysis revealed that these genes respond differently to various stress conditions, indicating their role in the plant's adaptation to extreme environments, particularly coral reefs.
Canavalia rosea (Sw.) DC is a perennial twining herb distributed in the semi-arid and saline-alkali areas of coastal regions and has evolved halotolerance. In this study, we present the first comprehensive survey of the metallothionein (MT) gene family in C.
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- Canavalia rosea, commonly known as bay bean, is a halophyte found in coastal tropical and subtropical regions, known for its ability to tolerate seawater and drought, potentially due to aquaporins (AQPs), which are proteins that help regulate water transport in plants.
- Researchers identified 37 different aquaporins in the C. rosea genome, categorized into five subgroups, and found that these AQPs exhibit organ-specific expression, suggesting some are crucial for the plant’s adaptation to extreme environments, like coral reefs.
- The study highlighted the significant role AQPs play in C. rosea's response to saline and drought conditions, enhancing our understanding of AQP functions and plant adaptation evolution.
Article Synopsis
- * The studied plant, a bay bean (Sw. DC.), is an extremophile that thrives in harsh conditions like seawater and drought, showcasing specific tolerance to metals, which could help in environmental cleanup.
- * A total of 12 CrMTP genes were identified, with analyses showing distinct subfamilies, organ-specific expressions, and potential roles in responding to heavy metal stress in extreme environments, leading to a better understanding of their functions in plants.
Article Synopsis
- - The text discusses bay bean, a halophyte found in tropical and subtropical coastal regions, known for its resilience to seawater and drought conditions.
- - It provides an analysis of late embryogenesis abundant (LEA) and abscisic acid-, stress-, and ripening-induced (ASR) genes, identifying 84 LEA genes and 3 ASR genes categorized into nine groups.
- - The study also examines gene expression in different plant tissues and introduces 10 selected genes into yeast to explore their functions, aiming to enhance understanding of genes in plants that thrive in extreme environments.
Background: Invasion and metastasis of cervical cancer are the main factors affecting the prognosis of patients with cervical squamous cell carcinoma (CESC). Therefore, it is of vital importance to find novel biomarkers that are associated with CESC invasion and metastasis, which will aid in the amelioration of individualized therapeutic methods for advanced patients.
Methods: The gene expression profiles of 10 metastatic and 116 non-metastatic samples were downloaded from The Cancer Genome Atlas (TCGA), where differentially expressed genes (DEGs) were defined.
Article Synopsis
- * The study focuses on a PIP2 gene cloned from a halophyte plant, examining its role in helping plants tolerate extreme salt-alkali and drought conditions, particularly under stress from high salinity and osmotic pressure.
- * Overexpression of this PIP2 gene in plants improved their survival and growth in drought conditions and increased tolerance to salt and alkaline environments, mainly by regulating water balance rather than enhancing the plant's ability to handle reactive oxygen species (ROS).
Article Synopsis
- Phytochelatin synthases (PCSs) are essential for plant heavy metal tolerance by producing phytochelatins that bind heavy metals, decreasing cell damage; they are important for phytoremediation efforts.
- A specific PCS gene, IpPCS1, was identified in the plant Ipomoea pes-caprae, and its role in cadmium (Cd) tolerance was examined, showing that a shortened version of this gene can improve Cd tolerance in yeast and induce Cd accumulation.
- Results indicate that while IpPCS1 can enhance Cd tolerance and might be beneficial for genetic engineering to improve plant phytoremediation, a new potential Cd activation site was also discovered in the gene's C-terminal region.
Some studies suggested the prognosis value of immune gene in lower grade glioma (LGG). Recurrence in LGG is a tough clinical problem for many LGG patients. Therefore, prognosis biomarker is required.
View Article and Find Full Text PDFLate embryogenesis abundant (LEA) proteins belong to a large family that exists widely in plants and is mainly involved in desiccation processes during plant development or in the response to abiotic stresses. Here, we reported on an atypical LEA gene (IpLEA) related to salt tolerance from Ipomoea pes-caprae L. (Convolvulaceae).
View Article and Find Full Text PDFIn this study, we reported on an ASR gene (TtASR) related to salt/drought tolerance from the edible halophyte Tetragonia tetragonoides (Pall.) Kuntze (Aizoaceae). A phylogenetic analysis revealed that TtASR was evolutionarily close to other two halophytic glycine-rich ASR members, SbASR-1 (from Salicornia brachiate) and SlASR (from Suaeda liaotungensis), with a typical abscisic acid (ABA)/water-deficit stress (WDS) domain at C-terminal.
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