Publications by authors named "Ruoyi Jin"
Spatial immunogenomic patterns associated with lymph node metastasis in lung adenocarcinoma.
Exp Hematol Oncol
October 2024
Article Synopsis
- This study investigates the immunogenomic characteristics of lung adenocarcinoma (LUAD) with lymph node (LN) metastasis, aiming to better understand its connection to poor patient prognosis.
- Researchers utilized next-generation sequencing and multiplex immunohistochemistry on a large patient cohort to map genetic alterations and analyze the immune environment in LUAD tumors.
- The findings highlight specific mutations and immune cell profiles linked to LN metastasis, allowing researchers to create a predictive model that could enhance personalized treatment strategies for patients who cannot undergo surgery.
Thymic epithelial tumors (TETs), consisting of thymomas, thymic carcinomas (TCs), and thymic neuroendocrine tumors, are rare diseases. Surgery remains the prime option in resectable and early-stage TETs, while chemotherapy, targeted therapy, and immunotherapy are also potential treatment modalities. However, the inadequate comprehension of the molecular landscape of TETs impedes the exploitation of such therapies.
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