Advanced imaging in the evaluation of lupus arthritis: A systematic literature review and meta-analysis.

Introduction: Joint involvement is present in up to 95 % of patients with SLE. Arthritis is a main cause of work-related disability and 70-80 % of lupus patients in clinical trials have active joint manifestations.

Objective: To review the evidence on the application of musculoskeletal (MSK) ultrasound (US), magnetic resonance imaging (MRI), and optical imaging (OI) in patients with SLE hand and wrist arthritis, discuss measurement properties of US, MRI, and OI, and to provide combined results from these studies.

Riluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin Diseases.

Nanocarriers, and especially nanostructured lipid carriers (NLC), represent one of the most effective systems for topical drug administration. NLCs are biodegradable, biocompatible and provide a prolonged drug release. The glutamate release inhibitor Riluzole (RLZ) is a drug currently used for amyotrophic lateral sclerosis (ALS), with anti-proliferative effects potentially beneficial for diseases with excessive cell turnover.