Publications by authors named "Ruoxin Weng"
Article Synopsis
- Observational studies have linked depression with several female reproductive disorders, but the causal relationships are still unclear.
- A comprehensive analysis using Mendelian randomization aimed to clarify these causal associations between genetically predicted depression and various reproductive issues, including PCOS, ovarian cysts, and endometriosis.
- The findings indicated that a genetic predisposition to depression increases the risk of developing certain conditions like PCOS and endometriosis, but no reverse causality was found, suggesting depression contributes to these disorders rather than the opposite.
Introduction: Polycystic Ovary Syndrome (PCOS) is the most common reproductive endocrine disorder among women of reproductive age, which is one of the main causes of anovulatory infertility. Even though the rapidly developed assisted reproductive technology (ART) could effectively solve fertility problems, some PCOS patients still have not obtained satisfactory clinical outcomes. The poor quality of oocytes caused by the abnormal follicular development of PCOS may directly contribute to the failure of ART treatment.
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