Publications by authors named "Ruovinuo Sachu"

Article Synopsis
  • Severe COVID-19 infection can trigger a hyperinflammatory immune response, resembling secondary hemophagocytic lymphohistiocytosis (sHLH), featuring symptoms like fever and elevated inflammatory markers, which are linked to high mortality rates.
  • A study of 47 severe COVID-19 patients explored the effectiveness of HLH 2004 and HScore diagnostic criteria for identifying COVID-related hyperinflammatory syndrome (COVID-HIS), finding that only a small percentage met the criteria, while the Temple criteria showed better predictive capabilities.
  • Key indicators such as serum ferritin, lactate dehydrogenase, direct bilirubin, and C-reactive protein were associated with mortality in patients with COVID-HIS, indicating that traditional HLH
View Article and Find Full Text PDF

Introduction: The clinical and laboratory features of severe COVID-19 infection overlap with those of hemophagocytic lymphohistiocytosis (HLH), a hyperinflammatory disorder often associated with several viral infections. The clinical syndrome of HLH encompasses fever, organomegaly, cytopenias, hyperferritinemia, hypertriglyceridemia, raised transaminases, hypofibrinogenemia, absent natural killer (NK) cell activity, increased soluble CD25 and hemophagocytic lymphohistiocytosis in bone marrow, spleen, and lymph nodes.

Methods: We analyzed clinicopathological and laboratory features of thirteen patients with severe COVID-19 infection suspected to have HLH and found to have hemophagocytic histiocytosis on bone marrow examination (BME).

View Article and Find Full Text PDF