Publications by authors named "Ruoran Guan"
Background: Neoantigens are promising immunogens for cancer vaccines and are often delivered as adjuvanted peptide vaccines. Adenoviral (Ad) vectors have been shown to induce strong CD8 T cell responses as vaccines against SARS-CoV-2, Ebola, and Zika, but their utility as neoantigen delivery vectors remains largely unexplored. In this study, we examine how an Ad-vectored neoantigen vaccine would impact tumor immunity compared with a peptide neoantigen vaccine.
View Article and Find Full Text PDFArticle Synopsis
- Zika virus (ZIKV), a mosquito-borne virus, led to a global outbreak in 2016-2017 and continues to circulate at lower levels in some regions as there is no approved vaccine.
- Researchers investigated a modified monoclonal antibody (mAb) known as ZIKV-117-LALA-YTE, which has been engineered to improve its effectiveness and longevity in the body.
- In tests on rhesus macaques, this antibody showed complete protection against ZIKV at a very low dose, highlighting its potential as a new treatment option for the virus.
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) variant BA.2.86 has over 30 mutations in spike compared with BA.
View Article and Find Full Text PDF