Evaluation of dynamic control of continuous capture with periodic counter-current chromatography under feedstock variations.

Multi-column periodic counter-current chromatography is a promising technology for continuous antibody capture. However, dynamic changes due to disturbances and drifts pose some potential risks for continuous processes during long-term operation. In this study, a model-based approach was used to describe the changes in breakthrough curves with feedstock variations in target proteins and impurities.

Genotype-Phenotype Correlation Reanalysis in 83 Chinese Cases with Mutations.

Background: Both Lowe syndrome and Dent-2 disease are caused by variants in the gene. However, the reason why patients with similar gene mutations presented with different phenotypes remains uncertain.

Methods: Children with hemizygous pathogenic or likely pathogenic variants in were compiled from published and unpublished consecutive cases from China.