[Loss of Myeloid-Derived Growth Factor Leads to Increased Fibrosis in Mice After Myocardial Infarction].

Objective: To investigate the effect of the loss of myeloid-derived growth factor (Mydgf) on the transformation of cardiac fibroblasts into myofibroblasts after myocardial infarction (MI).

Methods: Two adult mouse groups, including a wild-type (WT) group and another group with knockout (-KO), were examined in the study. The mice in these two groups were tested for their cardiac function by measuring left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) (=10).

Direct reprogramming of fibroblasts into functional hepatocytes via CRISPRa activation of endogenous Gata4 and Foxa3.

Background: The ability to generate functional hepatocytes without relying on donor liver organs holds significant therapeutic promise in the fields of regenerative medicine and potential liver disease treatments. Clustered regularly interspaced short palindromic repeats (CRISPR) activator (CRISPRa) is a powerful tool that can conveniently and efficiently activate the expression of multiple endogenous genes simultaneously, providing a new strategy for cell fate determination. The main purpose of this study is to explore the feasibility of applying CRISPRa for hepatocyte reprogramming and its application in the treatment of mouse liver fibrosis.

The digital health divide: Understanding telehealth adoption across racial lines in rural Illinois.

Due to long-standing barriers to healthcare access in rural areas, telehealth has been promoted as an effective means of delivering healthcare services. However, there is a general absence of quantitative data showing how geographic residence and race affect telehealth adoption. This study examines variations in telehealth adoption based on race and geographic residence in Southern Illinois using a mail survey.

IL-6/gp130 signaling: a key unlocking regeneration.

Liver is an organ with notable capacity of regeneration. Reprogramming of hepatocytes towards an immature state is one of the important mechanisms for hepatocyte replenishment. Inflammatory response mediated by IL-6 and its family cytokines has been widely reported closely related with tissue regeneration in myriads of organs.

Targeting immunoregulation for cardiac regeneration.

Inducing endogenous cardiomyocyte proliferation and heart regeneration is a promising strategy to treat ischemic heart failure. The immune response has recently been considered critical in cardiac regeneration. Thus, targeting the immune response is a potent strategy to improve cardiac regeneration and repair after myocardial infarction.

Antibacterial activity of γFe O /TiO nanoparticles on toxic cyanobacteria from a lake in Southern Illinois.

Frequent outbreaks of harmful algal blooms (HABs) have brought adverse impacts on human health, economic viability, and recreational activities in many communities in the United States. Cyanobacteria (or blue-green algae) blooms are the most common type of HABs in surface water. Current bactericides for controlling the blooms are disadvantageous due to the recycling difficulty.

Aerobic Cross-Dehydrogenative Coupling Reactions for Selective Mono- and Dithiolation of Phenols.

A highly efficient strategy for the direct thiolation of phenols under transition metal-free and solvent-free conditions has been developed. These reactions are operationally simple with employing air (molecular oxygen) as an ideal oxidant and can selectively provide mono- and dithiolation products in good to excellent yields under basic conditions. The reaction tolerates a broad range of aryl thiols and arenes and is especially applicable for large-scale synthesis.

A review on drone-based harmful algae blooms monitoring.

Rapid development and applications of unmanned aerial vehicles (UAVs) provide promising solutions to and new opportunities for environmental monitoring. Owing to their flexibility in flight scheduling, high spatial resolution, and costs-effectiveness, UAVs have become a popular tool for monitoring dynamic environmental processes, such as emergence and outbreak of harmful algae blooms (HABs). The HABs outbreak, often linked with anthropogenic eutrophication, has become a serious environmental health problem that threats our communities.

OxLDL promotes lymphangiogenesis and lymphatic metastasis in gastric cancer by upregulating VEGF‑C expression and secretion.

Gastric cancer is one of the most malignant tumor types, and its metastasis is a notable cause of mortality. Among the methods of tumor metastasis, lymphatic metastasis is the predominant one in gastric cancer. A previous study reported that the plasma oxidized low‑density lipoprotein (oxLDL) is the risk factor associated with the development of tumors in patients with abnormal lipid metabolism, but the influence of plasma oxLDL in the lymphatic metastasis of gastric cancer remains unclear.

Assessing Nebraska playa wetland inundation status during 1985-2015 using Landsat data and Google Earth Engine.

Playa wetlands in Nebraska provide globally important habitats for migratory waterfowl. Inundation condition is an important indicator of playa wetland functionality. However, there is a lack of long-term continuous monitoring records for playa wetlands.

Modeling vulnerability of groundwater to pollution under future scenarios of climate change and biofuels-related land use change: a case study in North Dakota, USA.

Modeling groundwater vulnerability to pollution is critical for implementing programs to protect groundwater quality. Most groundwater vulnerability modeling has been based on current hydrogeology and land use conditions. However, groundwater vulnerability is strongly dependent on factors such as depth-to-water, recharge and land use conditions that may change in response to future changes in climate and/or socio-economic conditions.