Enhanced mucosal immunity and protection against Aeromonas veronii infection in crucian carp via synergistic immunization with Bacillus coagulans and recombinant Lactobacillus casei expressing mshB gene.

Aeromonas veronii (A. veronii) is a pathogen that causes zoonotic diseases in humans, animals, and aquatic organisms, leading to symptoms such as scale loss, red and swollen anus, and hemorrhaging of tissues and organs in aquatic life. To better combat infections caused by A.

Bioequivalence of Aripiprazole Oral Soluble Films and Orally Disintegrating Tablets in Healthy Participants: A Crossover Study.

Schizophrenia is a serious mental disorder with high disability rates, and antipsychotics, especially second-generation ones like aripiprazole, are the cornerstone of treatment. As a novel formulation, oral soluble films (OSF) offer an alternative to tablets or capsules, improving patient compliance. This study aimed to assess the bioequivalence, pharmacokinetic (PK) properties, and safety of aripiprazole OSF and aripiprazole orally disintegrating tablets (ODT) in healthy Chinese participants.

Exploration on the potential efficacy and mechanism of methyl salicylate glycosides in the treatment of schizophrenia based on bioinformatics, molecular docking and dynamics simulation.

The etiological and therapeutic complexities of schizophrenia (SCZ) persist, prompting exploration of anti-inflammatory therapy as a potential treatment approach. Methyl salicylate glycosides (MSGs), possessing a structural parent nucleus akin to aspirin, are being investigated for their therapeutic potential in schizophrenia. Utilizing bioinformation mining, network pharmacology, molecular docking and dynamics simulation, the potential value and mechanism of MSGs (including MSTG-A, MSTG-B, and Gaultherin) in the treatment of SCZ, as well as the underlying pathogenesis of the disorder, were examined.

In-situ evaluation the fluctuation of hypochlorous acid in acute liver injury mice models with a mitochondria-targeted NIR ratiometric fluorescent probe.

Acute liver injury (ALI) is a frequent and devastating liver disease that has been made more prevalent by the excessive use of chemicals, drugs, and alcohol in modern life. Hypochlorous acid (HClO), an important biomarker of oxidative stress originating mainly from the mitochondria, has been shown to be intimately connected to the development and course of ALI. Herein, a novel BODIPY-based NIR ratiometric fluorescent probe Mito-BS was constructed for the specific recognition of mitochondrial HClO.

The Application Value of Internet Health Popularization for Community Patients with Hypertension.

Objective: To explore the effect of Internet health science popularization on the use of antihypertensive drugs in patients with hypertension in the community.

Methods: Ninety-six community hypertensive patients treated in our hospital from May 2021 to May 2023 were selected as the subjects of the study. According to the different intervention schemes received by the patients, they were equally divided into a control group (n = 48) and a study group (n = 48).

Population pharmacokinetic analysis and dosing regimen optimization of teicoplanin in critically ill patients with sepsis.

Teicoplanin has been extensively used in the treatment for infections caused by gram-positive bacteria including methicillin-resistant (MRSA). However, current teicoplanin treatment is challenging due to relatively low and variable concentrations under standard dosage regimens. This study aimed to investigate the population pharmacokinetics (PPK) characteristics of teicoplanin in adult sepsis patients and provide recommendations for optimal teicoplanin dosing regimens.

Miniature Fourier Transform Spectrometer Based on Thin-Film Lithium Niobate.

A miniature Fourier transform spectrometer is proposed using a thin-film lithium niobate electro-optical modulator instead of the conventional modulator made by titanium diffusion in lithium niobate. The modulator was fabricated by a contact lithography process, and its voltage-length and optical waveguide loss were 2.26 V·cm and 1.

Low-loss, ultracompact n-adjustable waveguide bends for photonic integrated circuits.

Countless waveguides have been designed based on four basic bends: circular bend, sine/cosine bend, Euler bend (developed in 1744) and Bezier bend (developed in 1962). This paper proposes an n-adjustable (NA) bend, which has superior properties compared to other basic bends. Simulations and experiments indicate that the NA bends can show lower losses than other basic bends by adjusting n values.

Growth modes of single-walled carbon nanotubes on catalysts.

Understanding the growth mechanism of single-walled carbon nanotubes (SWCNTs) and achieving selective growth requires insights into the catalyst structure-function relationship. Using an in situ aberration-corrected environmental transmission electron microscope, we reveal the effects of the state and structure of catalysts on the growth modes of SWCNTs. SWCNTs grown from molten catalysts via a vapor-liquid-solid process generally present similar diameters to those of the catalysts, indicating a size correlation between nanotubes and catalysts.

Comparative efficacy and safety of disease-modifying therapies in patients with relapsing multiple sclerosis: A systematic review and network meta-analysis.

Background: Currently, 19 disease-modifying therapies (DMTs) have been approved for the treatment of patients with relapsing forms of multiple sclerosis (RMS).

Objective: The objective of this study was to conduct a systematic review and network meta-analysis to evaluate the efficacy and safety of DMTs in adults with RMS.

Methods: We searched PubMed, Embase, the Cochrane Central Register of Controlled Trials, ClinicalTrials.

Pharmacokinetic Characteristics of Siponimod in Healthy Volunteers and Patients With Multiple Sclerosis: Analyses of Published Clinical Trials.

This study aimed to investigate the pharmacokinetic characteristics of siponimod in healthy volunteers and patients with MS based on aggregated data from published clinical trials, and to explore the factors influencing siponimod exposure. A total of 476 siponimod plasma concentrations aggregated from 28 dosage groups (corresponding to 294 healthy volunteers and 207 patients with MS) were collected from published clinical trials. Population pharmacokinetic (PPK) analysis was performed using a nonlinear, mixed-effect modeling approach.

Simultaneous frequency up/down converting interface based on a single hardware incorporating two phase-correlated photonic mixers.

A novel photonic frequency up/down-converting interface (FCI) with the capability of up-converting an intermediate frequency (IF) signal to a radio frequency (RF) signal and simultaneously down-converting a RF signal to a low IF signal is proposed, and a new application scenario, where both up and down frequency conversion stages of a deramp-on-receive linearly frequency modulated (LFM) continuous wave (CW) radar system are replaced by the FCI, is demonstrated. The five-port photonic FCI can be seen as two ultra-wideband phase-correlated photonic RF mixers incorporated in a single hardware, and the working frequency range of the FCI is up to Ka-band. The FCI is tested by an LFM waveform with 1GHz bandwidth in a deramp-on-receive LFM CW imaging radar system.

Effect of different initial rituximab regimens on B cell depletion in children with autoimmune neurological diseases.

Background: Rituximab (RTX) is a promising B-cell-depleting monoclonal antibody used to treat several autoimmune neurological diseases in children. The RTX administration regimen relies on the reconstitution of B cells in the peripheral blood.

Objective: The objective of this study was to investigate the effect of different initial RTX regimens on B cell depletion.

Host-Guest Molecular Interaction Enabled Separation of Large-Diameter Semiconducting Single-Walled Carbon Nanotubes.

Semiconducting single-walled carbon nanotubes (s-SWCNTs) with a diameter of around 1.0-1.5 nm, which present bandgaps comparable to silicon, are highly desired for electronic applications.

Dalfampridine in the treatment of multiple sclerosis: a meta-analysis of randomised controlled trials.

Background: Multiple sclerosis (MS) is a chronic illness involving the central nervous system (CNS) that is characterised by inflammation, demyelination, and degenerative changes. Dalfampridine is one of the available treatments for MS symptoms and comorbidities. This meta-analysis aimed to assess the safety and benefits of dalfampridine versus placebo in MS by summarising data deriving from previously published clinical randomised controlled studies (RCTs).

5-HT Receptor and 5-HT Degradation Play a Crucial Role in Atherosclerosis by Modulating Macrophage Foam Cell Formation, Vascular Endothelial Cell Inflammation, and Hepatic Steatosis.

Aim: Previously, we found that diabetes-related liver dysfunction is due to activation of the 5-HT receptor (5-HTR) and increased synthesis and degradation of 5-HT. Here, we investigated the role of 5-HT in the development of atherosclerosis.

Methods: The study was conducted using high-fat diet-fed male ApoE mice, THP-1 cell-derived macrophages, and HUVECs.

Denosumab Versus Zoledronic Acid in the Prevention of Skeletal-related Events in Vulnerable Cancer Patients: A Meta-analysis of Randomized, Controlled Trials.

Purpose: Bone metastases from solid tumors and multiple myeloma (MM) represent an important source of morbidity. The present meta-analysis was performed with the purpose of comparing the efficacy and tolerability of denosumab versus zoledronic acid (ZA) in the prevention of skeletal-related events (SREs) in patients with bone metastases secondary to solid tumors or bone lesions in multiple myeloma.

Methods: We searched PubMed, PubMed Central, EMBASE, the Cochrane Library, and ClinicalTrials.

Channelized photonic-assisted deramp receiver with an extended detection distance along the range direction for LFM-CW radars.

A novel photonic-assisted deramp receiver extends detection distance along range direction of linearly-frequency-modulated continuous wave (LFM-CW) radars is proposed. A dual-polarization quadrature phase shift keying (DP-QPSK) modulator is used to modulate an optical frequency-comb (OFC) to generate orthogonally polarized optical signals. Then the orthogonally polarized optical signals are coherently detected with an optical local oscillator (OLO), which is generated by modulating the other OFC with the RF-reference signal on a null-biased Mach-Zehnder modulator (MZM).

Wide-band RF receiver based on dual-OFC-based photonic channelization and spectrum stitching technique.

A novel wide-band RF receiver based on a dual-OFC-based channelization and spectrum stitching technique is proposed and demonstrated experimentally. In the scheme, a dual-OFC-based channelizer is utilized as the front-end to slice the RF signals into multiple channels. In the back-end, through the channel estimation and spectrum stitching, the received signals can be well reconstructed in the digital domain.

Study of lung toxicity in rats exposed to silica powder with different hard metal constituents.

The objective of this study was to assess the lung toxicity induced by the inhalation of different hard metal constituents and silica powder and screen for potential toxicity biomarkers. Rats were randomly divided into saline, cobalt, tungsten carbide, silica, and hard metal (HM) groups and were administered a single 10-mg dose of the respective treatments. After 8 weeks, the lung tissue structure in the HM group was deformed, numerous nucleated giant and epithelial-like cells appeared in the stroma, and the computed tomography scanning images appeared abnormal.

Demonstration of a microwave photonic synthetic aperture radar based on photonic-assisted signal generation and stretch processing.

A microwave photonic synthetic aperture radar (MWP SAR) is developed and experimentally demonstrated. In the transmitter, microwave photonic frequency doubling is used to generate a linearly-frequency-modulated (LFM) radar signal; while in the receiver, photonic stretch processing is employed to receive the reflection signal. The presented MWP SAR operates in Ku band with a bandwidth of 600MHz, and is evaluated through a series of inverse SAR imaging tests both in a microwave anechoic chamber and in a field trial.

Frequency tunable optoelectronic oscillator based on a directly modulated DFB semiconductor laser under optical injection.

A frequency tunable optoelectronic oscillator based on a directly modulated distributed-feedback (DFB) semiconductor laser under optical injection is proposed and experimentally demonstrated. Through optical injection, the relaxation oscillation frequency of the DFB laser is enhanced and its high modulation efficiency can enable the loop oscillation with a RF threshold gain of less than 20 dB. The DFB laser is a commercial semiconductor laser with a package of 10 GHz, and its packaging limitation can be overcome by optical injection.

Real time interrogation technique for fiber Bragg grating enhanced fiber loop ringdown sensors array.

A novel fiber Bragg grating aided fiber loop ringdown (FLRD) sensor array and the wavelength-time multiplexing based interrogation technique for the FLRD sensors array are proposed. The interrogation frequency of the system is formulated and the interrelationships among the parameters of the system are analyzed. To validate the performance of the proposed system, a five elements array is experimentally demonstrated, and the system shows the capability of real time monitoring every FLRD element with interrogation frequency of 125.

(n,m) Assignments and quantification for single-walled carbon nanotubes on SiO2/Si substrates by resonant Raman spectroscopy.

The single-walled carbon nanotubes (SWNTs) on silicon substrates are a promising candidate for the next generation of electronic and photoelectronic devices, therefore an easy, convenient, and nondestructive method for characterizing such samples is quite important and strongly needed. In this study, we provide in detail such a method to assign (n,m) indices with considerable accuracy through resonant Raman spectra analysis. We developed an equation of ωRBM = 235.