Publications by authors named "Ruolin Xiu"
Article Synopsis
- The study investigates noninvasive clinical indicators for predicting arsenic trioxide (ATO)-induced hepatotoxicity in patients with acute promyelocytic leukemia (APL), revealing that over half of the patients experience this side effect during early treatment.
- Significant risk factors identified include elevated hemoglobin levels, use of nonprophylactic hepatoprotective agents, and low fibrinogen levels, which could help tailor ATO treatment for individual patients.
- The methodology involved analyzing patient data from electronic health records and using statistical tests to confirm the association between these risk factors and hepatotoxicity, with a call for future prospective studies to further validate the results.
Objectives: The remarkable effect of arsenic trioxide (ATO) was verified, but elevated gamma-glutamyltransferase (GGT), aminotransferases (ALT and AST) are generally observed in acute promyelocytic leukemia (APL) patients undergoing ATO treatment. However, utilization of hepatoprotective agents or discontinuation of ATO may inhibit ATO efficacy. In order to maintain ATO effect from hepatoprotective agents' influence so we investigate relationships between single elevation in GGT and hepatocellular injury in this study.
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