Loss of hepatic FTCD promotes lipid accumulation and hepatocarcinogenesis by upregulating PPARγ and SREBP2.

Background & Aims: Exploiting key regulators responsible for hepatocarcinogenesis is of great importance for the prevention and treatment of hepatocellular carcinoma (HCC). However, the key players contributing to hepatocarcinogenesis remain poorly understood. We explored the molecular mechanisms underlying the carcinogenesis and progression of HCC for the development of potential new therapeutic targets.

Construction of BiOCl/Ti-MOFs type-II heterojunction photocatalyst for enhanced photocatalytic performance for multiple antibiotics removal.

The increased threats to environmental and human health caused by the widespread use of antibiotics have increased the need for efficient technologies for removing antibiotic remnants from wastewater after production. Photocatalysis, which is non-toxic, highly efficient, and low energy consumption, has played a vital role in wastewater treatment among the aforementioned technologies. Therefore, a MIL-125(Ti)/BiOCl type-II heterojunction photocatalyst was fabricated using solvothermal method.

Sustained activation of EGFR-ERK1/2 signaling limits the response to tigecycline-induced mitochondrial respiratory deficiency in liver cancer.

Background: Identification of tumor dependencies is important for developing therapeutic strategies for liver cancer.

Methods: A genome-wide CRISPR screen was performed for finding critical vulnerabilities in liver cancer cells. Compounds screen, RNA sequencing, and human phospho-receptor tyrosine kinase arrays were applied to explore mechanisms and search for synergistic drugs.

The adsorption property of in-situ synthesis of MOF in alginate gel for ofloxacin in the wastewater.

Although metal-organic frameworks (MOFs) are advantageous to the removal of organic pollutants, the general MOFs in powder form is disadvantageous to their practical applications. In-situ MOF synthesis in alginate gel is a good way to fabricate an MOF composite for many applications, which is different from blending MOF particles with polymers. In-situ synthesis of Zeolitic Imidazolate Framework-8 (ZIF-8) in alginate gel is in the form of beads with rough wrinkles and has many pores inside.

Effective Halogen- and Phosphorus-Free Polyphenylene Ether Resin-Based Flame-Retardant Foam.

A novel halogen- and phosphorus-free intrinsic flame-retardant foam is fabricated from curable phenol-terminated polyphenylene ether resin with a high molecular weight using phenol, formaldehyde, and diphenyl ether as starting materials. The limiting oxygen index (LOI) of the pure foam is 24.90% ± 0.

Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression.

Studies indicate that mutant α-synuclein (mαSyn) is involved in the pathogenesis of Parkinson's disease (PD). The mαSyn expression leads to the loss of dopaminergic neurons in the substantia nigra (SN) and consequent motor dysfunctions. Additionally, studies found that PD was accompanied by extensive neuroinflammation of SN.

Effect of ultrasonic separation on the structure and properties of diallyl phthalate prepolymer.

The bulk polymerization of diallyl phthalate (DAP) was carried out at high temperature (190 degrees C) without using any initiator, and the reaction was stopped before the gelation point in order to get the prepolymer of DAP. The mixture for the prepolymer and the monomer was successfully separated by a novel ultrasonic method for the first time, and the separation efficiency for the new method was obviously higher than that for the traditional reprecipitation. The product obtained by ultrasonic separation was characterized by infrared spectroscopy (IR), gel permeation chromatography (GPC) and iodine number measurement.