Publications by authors named "Ruobing Cui"
Mitochondria serve a crucial role in cell growth and proliferation by supporting both ATP synthesis and the production of macromolecular precursors. Whereas oxidative phosphorylation (OXPHOS) depends mainly on the oxidation of intermediates from the tricarboxylic acid cycle, the mitochondrial production of proline and ornithine relies on reductive synthesis. How these competing metabolic pathways take place in the same organelle is not clear.
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- Recent advancements in genetic manipulation have made it possible to create specific deletions in mitochondrial DNA (mtDNA) in human cells, which can help study diseases linked to these genetic changes.
- A method involving co-expression of end-joining machinery and targeted endonucleases was developed, showcasing effectiveness by generating clonal cell lines with a significant mtDNA deletion and varying levels of heteroplasmy.
- Research showed that when mtDNA deletion reached around 75%, it led to severe cellular dysfunction and identified distinct nuclear gene expression changes in response to mtDNA deletions, suggesting insights for potential therapies.
Cyclometalated iridium(III) complexes are of significant importance in the field of antitumor photodynamic therapy (PDT), whether they exist as single molecules or are incorporated into nanomaterials. Nevertheless, a comprehensive examination of the relationship between their molecular structure and PDT effectiveness remains awaited. The influencing factors of two-photon excited PDT can be anticipated to be further multiplied, particularly in relation to intricate nonlinear optical properties.
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