Publications by authors named "RuoWen Xiao"
Background: Accumulating evidence has shown that circular RNAs (circRNAs) are involved in gastric cancer (GC) tumorigenesis. However, specific functional circRNAs in GC remain to be discovered, and their underlying mechanisms remain to be elucidated.
Methods: CircRNAs that were differentially expressed between GC tissues and controls were analyzed using a circRNA microarray dataset.
Increasing evidence suggests that key cancer-causing driver genes continue to exert a sustained influence on the tumor microenvironment (TME), highlighting the importance of immunotherapeutic targeting of gene mutations in governing tumor progression. TP53 is a prominent tumor suppressor that encodes the p53 protein, which controls the initiation and progression of different tumor types. Wild-type p53 maintains cell homeostasis and genomic instability through complex pathways, and mutant p53 (Mut p53) promotes tumor occurrence and development by regulating the TME.
View Article and Find Full Text PDFWiskott-Aldrich syndrome protein-interacting protein family member 1 (WIPF1) is associated with malignant tumor progression. However, molecular links between WIPF1 and gastric cancer (GC) remain elusive. The expression of WIPF1 was detected in GC tissues and cells.
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- Radiation-induced brain injury (RBI) significantly impacts the quality of life and survival rates for patients with nasopharyngeal carcinoma (NPC), prompting the need for improved risk stratification tools.
- A large study involving 1189 NPC patients undergoing radiotherapy led to the development of a polygenic risk score (PRS) that effectively identifies individuals at high risk for RBI, with suggested adjusted radiation doses to minimize risk based on genetic predisposition.
- The integration of PRS with clinical factors enhanced prediction accuracy for RBI, indicating that personalized treatment strategies could be developed to optimize patient outcomes.
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- Large-scale genetic studies found several genetic loci linked to nasopharyngeal carcinoma (NPC), prompting further investigation into biological mechanisms behind these associations.
- A follow-up study involving nearly 7,000 NPC cases and over 10,000 controls identified two new susceptibility loci (9q22.33 and 17q12) and confirmed the role of two previously known loci linked to NPC risk.
- Functional analyses revealed that the genes PHF2 and CDKN2B-AS1 at these loci are crucial for NPC development, with risk alleles affecting their expression levels and consequently promoting NPC cell proliferation.
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- - Chemoradiation-induced hearing loss (CRIHL) significantly impacts the long-term quality of life for patients with nasopharyngeal carcinoma (NPC), with age, tumor stage, and cisplatin dosage being key risk factors identified in the study.
- - A genome-wide association study (GWAS) on 777 NPC patients found a specific genetic variant (rs1050851) linked to a 5.46-fold increased risk of hearing loss, indicating a potential genetic predisposition associated with the condition.
- - The research suggests a genetic overlap between hereditary deafness and CRIHL, emphasizing the role of synaptic signaling in hearing loss development and allowing for improved risk prediction for personalized prevention strategies.
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- Researchers aimed to find genetic mutations that contribute to the risk of familial nasopharyngeal carcinoma (NPC) by studying 13 families with multiple cases of the disease.
- Whole-exome sequencing identified three rare mutations in the POLN gene that showed a strong association with familial NPC and affected the gene’s ability to support viral replication.
- The study concluded that the POLN gene is a susceptibility factor for familial NPC, with mutations leading to decreased protein stability and impaired viral function, highlighting its role in the disease's biology.
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- Nasopharyngeal carcinoma (NPC) is linked to genetic factors and Epstein-Barr virus infection, making genetic counseling essential for high-risk families.
- A study involving whole-exome sequencing of 502 familial NPC patients revealed rare mutations in known cancer genes and identified 6 new susceptibility genes, with RAD54L showing the highest prevalence.
- Findings suggest that individuals with both rare and common genetic variants face significantly higher NPC risk, paving the way for better risk assessment and prevention strategies for those with a family history of the disease.
Polygenic risk scores (PRS) have the potential to identify individuals at risk of diseases, optimizing treatment, and predicting survival outcomes. Here, we construct and validate a genome-wide association study (GWAS) derived PRS for nasopharyngeal carcinoma (NPC), using a multi-center study of six populations (6 059 NPC cases and 7 582 controls), and evaluate its utility in a nested case-control study. We show that the PRS enables effective identification of NPC high-risk individuals (AUC = 0.
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- Epstein-Barr virus (EBV) is linked to pulmonary lymphoepithelioma-like carcinoma (pLELC), a rare lung cancer, but its genomic characteristics in relation to this cancer are not fully understood.
- A study analyzed whole-genome data from EBV isolated in 78 pLELC patients and 37 healthy controls, revealing 3,995 variations, particularly in latent genes, and identified 32 variations significantly associated with pLELC.
- The study established a global overview of EBV genomic profiles in pLELC patients, indicating that the EBV strains from pLELC are more similar to those found in nasopharyngeal carcinoma and showed
Background: MicroRNAs, as small non-coding RNAs, play an important role in tumorigenesis. MiR-483-5p was found to have a significant increase as a diagnostic biomarker of nasopharyngeal carcinoma (NPC), not only in plasma from NPC patients but also in tumor cell lines and biopsy tissues in our previous study. However, its function and mechanism in NPC are still unclear.
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- Nasopharyngeal carcinoma (NPC) is linked to the Epstein-Barr virus and is particularly common in southern China; the study examines the role of human leukocyte antigen (HLA) variants in influencing EBV reactivation, a key factor in NPC development.
- A research team analyzed HLA alleles of 1,078 healthy males in the region and assessed EBV Zta-IgA levels, using logistic regression to examine the relationship between HLA variants and EBV activation, considering smoking as a factor.
- Results show that the HLA-DRB1*09:01 allele is associated with increased risk for Zta-IgA positivity, especially in smokers, indicating the need for smoking cessation efforts
Background: Radiation-induced oral mucositis (OM) is one of the most common acute complications for head and neck cancer. Severe OM is associated with radiation treatment breaks, which harms successful tumor management. Radiogenomics studies have indicated that genetic variants are associated with adverse effects of radiotherapy.
View Article and Find Full Text PDFmiR-18a has been reported to be upregulated in nasopharyngeal carcinoma (NPC) tissues by microarray assays. However, the roles and the underlying mechanisms of miR-18a in NPC remain poorly understood. Here we demonstrated by real-time RT-PCR that miR-18a expression is upregulated in NPC tissues, and positively correlated with tumor size and TNM stage.
View Article and Find Full Text PDFBackground: Nasopharyngeal carcinoma (NPC) is a highly aggressive neoplasm mainly distributed in the eastern and southeastern parts of Asia. NPC has a poor prognosis among head and neck cancers, and molecular-targeted therapies showed limited clinical efficacy.
Methods: We reviewed publications in the PubMed database and extracted genes associated with NPC.
Deregulated microRNAs play an important role in the development and progression of various types of cancer. In our previous study, we observed that microRNA‑342‑3p (miR‑342‑3p) was one of the most markedly downregulated microRNAs in two nasopharyngeal carcinoma (NPC) cell lines compared to non‑neoplastic cells by using whole genome small RNA sequencing. In the present study, we confirmed that the expression of miR‑342‑3p was significantly reduced in NPC tissues compared with normal nasopharyngeal epithelial tissues.
View Article and Find Full Text PDFEpithelial cell adhesion molecule (EpCAM) is known to be highly expressed in a variety of epithelial carcinomas, and it is involved in cell adhesion and proliferation. However, its expression profile and biological function in nasopharyngeal carcinoma (NPC) remains unclear. In this study, higher expression of EpCAM was found in NPC samples compared with non-cancer nasopharyngeal mucosa by qRT-PCR.
View Article and Find Full Text PDFBone morphogenetic protein-2 (BMP2) is a secreted protein that highly expressed in a variety of cancers and contributes to cell proliferation, migration, invasiveness, mobility, metastasis and EMT. However, its clinical significance and biological function in nasopharyngeal carcinoma (NPC) remain unknown up to now. Up-regulation of BMP2 was first observed in NPC cell lines by a genome-wide transcriptome analysis in our previous study.
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