An improved FLARE system for recording and manipulating neuronal activity.

Recording and manipulating neuronal ensembles that underlie cognition and behavior is challenging. FLARE is a light- and calcium-gated transcriptional reporting system for labeling activated neurons on the order of minutes. However, FLARE is limited by its sensitivity to prolonged neuronal activities.

Exploring the therapeutic potential of Abelmoschi Corolla in psoriasis: Mechanisms of action and inflammatory pathway disruption.

Background: Psoriasis is a prevalent chronic inflammatory skin condition for which existing treatments often fall short of fully addressing patient needs. Abelmoschi Corolla (AC), a traditional Chinese medicine, and its ethanol extract, huangkui capsule, are well established for the treatment of chronic kidney diseases. The therapeutic mechanisms of AC include anti-inflammatory effects and immune modulation, which align with psoriasis treatment strategies.

An epiallele of a gene encoding a PfkB-type carbohydrate kinase affects plant architecture in maize.

Plant architecture greatly contributes to grain yield, but the epigenetic regulation of plant architecture remains elusive. Here, we identified the maize (Zea mays L.) mutant plant architecture 1 (par1), which shows reduced plant height, shorter and narrower leaves, and larger leaf angles than the wild type.

Correlation between obesity and Alzheimers disease and the mechanisms.

Alzheimer's disease (AD) is a progressive central neurodegenerative disorder with an insidious onset. With global aging, the incidence and mortality of AD have been steadily increasing, yet effective treatments remain elusive. Obesity, characterized by excessive or abnormal fat accumulation, is a complex metabolic disorder and a confirmed risk factor for numerous diseases.

Childhood obesity and central precocious puberty.

Central precocious puberty (CPP) is an endocrine disorder in children caused by the early activation of the hypothalamic-pituitary-gonadal axis (HPGA), leading to elevated gonadotropin-releasing hormone (GnRH), which triggers the development of gonads and the secretion of sex hormones. This eventually results in the development of internal and external genitalia and secondary sexual characteristics. CPP significantly affects the physical and mental health of children and may increase the risk of various adult diseases.

Influence of different temperatures and diets on the life cycle of invasive species .

Understanding the interactive effects of temperature and diet on insect life cycles is crucial for effective pest management. Here, the influence of different temperatures and diets on the life cycle of was investigated using the age-stage, two-sex life table analysis. The results support the hypothesis that temperature and diets (maize, apple, and artificial diet) significantly influence the entire life cycle performance of .

Gender and Age Differences in the Relationship Between Smartphone Addiction and Sleep Duration in Korean Children: A Panel Quantile Regression Study.

Purpose: This study analyzed the longitudinal relationship between smartphone addiction and sleep duration to investigate the factors contributing to sleep deprivation in Korean children.

Methods: To overcome the limitations of previous studies, panel quantile regression analysis was used to evaluate the relationship between smartphone addiction and sleep duration. Key variables were smartphone addiction, sleep duration, gender, and age.

The KLF16/MYC feedback loop is a therapeutic target in bladder cancer.

Background: Bladder cancer (BLCA) is a common malignancy characterized by dysregulated transcription and a lack of effective therapeutic targets. In this study, we aimed to identify and evaluate novel targets with clinical potential essential for tumor growth in BLCA.

Methods: CRISPR-Cas9 screening was used to identify transcription factors essential for bladder cancer cell viability.

On-road measurement of post-catalyst ammonia emissions from gasoline and hybrid vehicles using quantum cascade laser detector.

Ammonia emissions from gasoline vehicles have been confirmed an essential precursor of urban secondary aerosols. To more comprehensively understand the formation mechanisms and better control vehicle-related ammonia, this paper measured the on-road ammonia emissions from six conventional and four hybrid vehicles using a state-of-the-art Quantum Cascade Laser analyzer on urban, rural, and highway routes. The test vehicles emitted 0.

Impacts of long-term different fertilization regimes on microbial utilization of straw-derived carbon in greenhouse vegetable soils: insights from its ecophysiological roles and temperature responses.

As the largest organic carbon input in the agroecosystems, crop residues can increase soil carbon sequestration and crop production in greenhouse vegetable fields (GVFs). However, the soil microbiological mechanisms driving straw decomposition in GVFs under different incubation temperatures and fertilization treatments are not clear. Thus, soil samples were collected from a long-term field experiment included chemical fertilizer application alone (CF), 2/4 fertilizer N+2/4 organic fertilizer N (CM), 2/4 fertilizer N+1/4 organic fertilizer N+1/4 straw N (CMS), 2/4 fertilizer N+2/4 straw N (CS), and incubated with C-labeled straw at different temperatures (15, 25, and 35°C) for 60 days.

Bioactivity-Guided Isolation of Secondary Metabolites from : Antioxidative Antibacterial Activities and Anti-Inflammatory Hypoglycemic Molecular Docking.

is a valuable ornamental, edible, and medicinal plant with promising prospects for bioactivity development. We screened the bioactivity of eight fractions (Fr. A-I) obtained from the ethyl acetate phase of via silica gel column chromatography.

Effects of Ginseng Consumption on Cardiovascular Health Biomarkers in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Ginseng, with various pharmacological activities, has received increasing attention to improve cardiovascular health (CVH). Therefore, this meta-analysis synthesized the effect of ginseng consumption on biomarkers of CVH in adults. A systematic search was performed in the databases of PubMed, Scopus, Web of Science, Embase, and the Cochrane Library through July 24, 2023 to screen out English-language randomized controlled trials (RCTs) evaluating the effects of ginseng consumption on body composition, blood pressure, vascular stiffness, lipid metabolism, glucose metabolism, insulin resistance, inflammatory cytokines, and adipocytokines in adults.

Potential therapies for non-coding RNAs in breast cancer.

Breast cancer (BC) is one of the frequent tumors that seriously endanger the physical and mental well-being in women with strong heterogeneity, and its pathogenesis involves multiple risk factors. Depending on the type of BC, hormonal therapy, targeted therapy, and immunotherapy are the current systemic treatment options along with conventional chemotherapy. Despite significant progress in understanding BC pathogenesis and therapeutic options, there is still a need to identify new therapeutic targets and develop more effective treatments.

Impact of postsurgical vaginal microbiome on high-risk HPV infection and recurrence risk in patients with cervical cancer and intraepithelial neoplasia: A retrospective study.

Purpose: This study aimed to determine the effect of postsurgical vaginal microbiome (VM) on high-risk human papillomavirus (hrHPV) infection and the risk of disease recurrence in patients surgically treated for cervical cancer (CC) or intraepithelial neoplasia (CIN).

Methods: 207 women who underwent surgical treatment for CC or CIN at the Department of Gynecologic Oncology of the First Affiliated Hospital of University of Science and Technology of China from November 2016 to October 2023 were included. The patients' clinical data, including age, surgical modality, and diagnosis at time of index surgery, were collected retrospectively and analyzed.

Silicon quantum dots based fluorescent probes for detecting methyl parathion pesticide residues in potato, tap water and Yellow River.

In this paper, a novel ratiometric fluorescent probe based on silicon quantum dots (SiQDs) has been developed for the sensitive detection of methyl parathion pesticide residues. The silicon quantum dots were prepared by a simple hydrothermal reaction process using 3-Aminopropyltriethoxysilane (APTES) as silicon resource and were characterized by the analysis of transmission electron microscopy, FTIR spectroscopy, and X-ray photoelectron spectroscopy. The silicon quantum dots displayed characteristic blue fluorescence emission at 440 nm.

A new method to quantify the impacts of human activity on soil conservation service.

Human activities and climate change impact ecosystem services, thereby affecting economic and social sustainable development. Measuring the heterogeneity in space and time of how human activities affect ecosystem services poses a challenge for the sustainable management of land resources. Based on "human appropriation of net primary production (HANPP) - Fractional Vegetation Cover (FVC) - Soil Conservation Service (SCS)" cascading effect, first, a geographically and temporally weighted regression (GTWR) model was employed to assess the impact of HANPP in percent of potential NPP (hereafter HANPP%) on the FVC; second, changes in the FVC caused by human activities were quantified; and third, the potential soil conservation service (SCS) and actual soil conservation service (SCS) were estimated using the Revised Universal Soil Loss Equation (RUSLE) model, and the difference between them represented the changes in soil conservation service caused by human activities (SCS).

Transsynaptic BMP Signaling Regulates Fine-Scale Topography between Adjacent Sensory Neurons.

Sensory axons projecting to the central nervous system are organized into topographic maps that represent the locations of sensory stimuli. In some sensory systems, even adjacent sensory axons are arranged topographically, forming "fine-scale" topographic maps. Although several broad molecular gradients are known to instruct coarse topography, we know little about the molecular signaling that regulates fine-scale topography at the level of two adjacent axons.

Cavity-Induced Optical Nonreciprocity Based on Degenerate Two-Level Atoms.

We developed and experimentally realized a scheme of optical nonreciprocity (ONR) by using degenerate two-level atoms embedded in an optical ring cavity. For the degenerate transition F = 4 ↔ F = 3, we first studied the cavity-transmission property in different coupling field configurations and verified that under the strong-coupling regime, the single-dark-state peak formed by electromagnetically induced transparency (EIT) showed ONR. The stable ground-state Zeeman coherence for Λ-chains involved in the degenerate two-level system was found to be important in the formation of intracavity EIT.

Autophagy-mediated activation of the AIM2 inflammasome enhances M1 polarization of microglia and exacerbates retinal neovascularization.

Retinopathy of prematurity (ROP) is a retinal neovascularization (RNV) disease that is characterized by abnormal blood vessel development in the retina. Importantly, the etiology of ROP remains understudied. We re-analyzed previously published single-cell data and discovered a strong correlation between microglia and RNV diseases, particularly ROP.

Bioactivity-Guided Isolation of Secondary Metabolites with Antioxidant and Antimicrobial Activities from .

has important ornamental, medicinal, and food values, which also have tremendous potential for exploiting bioactivities. We performed the bioactivity-guided (antioxidant and antimicrobial) screening of eight fractions obtained from the ethyl acetate phase of . The antioxidant activity was measured by DPPH, ABTS, and FRAP, and the antibacterial activity was measured by the minimum inhibitory concentration (MIC) of , and .