Publications by authors named "Ruo-qiu Fu"
Anticancer activities of flavonoids derived from Tephroseris kirilowii (Turcz.) Holub. were evaluated in human cancer cells.
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- - Mitochondria fission and mitophagy are essential for cell health and contribute significantly to cancer development, so understanding these processes could lead to better cancer therapies.
- - Cofilin, an actin-depolymerizing factor, plays a vital role in regulating mitochondrial fission and mitophagy, but its exact mechanisms are not well-understood.
- - Research shows that knocking down cofilin reduces, while overexpressing it enhances mitochondrial fission and mitophagy, linking its effects to mitochondrial proteases and actin dynamics during stress treatments.
The molecular mechanisms underlying the anti-breast cancer effects of polyphyllin I, a natural compound extracted from Paris polyphylla rhizomes, are not fully understood. In the present study, we found that polyphyllin I induces mitochondrial translocation of DRP1 by dephosphorylating DRP1 at Ser637, leading to mitochondrial fission, cytochrome c release from mitochondria into the cytosol and, ultimately apoptosis. Polyphyllin I also increased the stabilization of full-length PINK1 at the mitochondrial surface, leading to the recruitment of PARK2, P62, ubiquitin, and LC3B-II to mitochondria and culminating in mitophagy.
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- The study talks about a treatment for port-wine stains (PWSs) called photodynamic therapy (PDT), which uses special light-sensitive drugs, but the usual ones don’t work well and can be harmful over time.
- Researchers found that a drug called hypericin works much better than the usual treatments by killing bad cells when exposed to light and causing a reaction that makes cells die.
- They also learned how hypericin does this and believe it could be a safer and more effective choice for treating PWSs compared to the traditional drug, haematoporphyrin (HP).
Article Synopsis
- Hypericin (HY) is highlighted as a strong photosensitizer for photodynamic therapy (PDT) in treating port-wine stains, which are congenital skin conditions caused by faulty blood vessels.
- In experiments, HY demonstrated notable effectiveness in hindering the growth of human vascular endothelial cells (HUVECs) and inducing apoptosis (cell death) more efficiently than another photosensitizer, hematoporphyrin (HP).
- Additionally, studies using a chicken cockscomb model confirmed HY's photocytotoxic effects, characterized by significant changes in mitochondrial structure and increased release of cytochrome c, signaling its potential as a highly effective treatment option for PWS.