Synergistic acceleration of machine learning and molecular docking for prostate-specific antigen ligand design.

Prostate-specific antigen (PSA) serves as a critical biomarker for the early detection and continuous monitoring of prostate cancer. However, commercial PSA detection methods primarily rely on antigen-antibody interactions, leading to issues such as high costs, stringent storage requirements, and potential cross-reactivity due to PSA variant sequence homology. This study is dedicated to the precise design and synthesis of molecular entities tailored for binding with PSA.

Hsa_circ_0005397 promotes hepatocellular carcinoma progression through EIF4A3.

Purpose: The purpose of this study was to explore the expression and potential mechanism of hsa_circ_0005397 in hepatocellular carcinoma progression.

Methods: Quantitative reverse transcription-polymerase chain reaction(qRT-PCR) was used to measure the expression level of hsa_circ_0005397 and EIF4A3 from paired HCC tissues and cell lines. Western Blot (WB) and immunohistochemistry (IHC) were used to verify the protein level of EIF4A3.

Cotyledon-Specific Flow Evaluation of Rhesus Macaque Placental Injury Using Ferumoxytol Dynamic Contrast-Enhanced MRI.

Background: Recently, dynamic contrast-enhanced (DCE) MRI with ferumoxytol as contrast agent has recently been introduced for the noninvasive assessment of placental structure and function throughout. However, it has not been demonstrated under pathological conditions.

Purpose: To measure cotyledon-specific rhesus macaque maternal placental blood flow using ferumoxytol DCE MRI in a novel animal model for local placental injury.

Single-nucleus transcriptional profiling uncovers the reprogrammed metabolism of astrocytes in Alzheimer's disease.

Astrocytes play an important role in the pathogenesis of Alzheimer's disease (AD). It is widely involved in energy metabolism in the brain by providing nutritional and metabolic support to neurons; however, the alteration in the metabolism of astrocytes in AD remains unknown. Through integrative analysis of single-nucleus sequencing datasets, we revealed metabolic changes in various cell types in the prefrontal cortex of patients with AD.

Resection of Insular Glioma Through the Transfrontal Limiting Sulcus Approach.

Background: The current transsylvian or transopercular approaches make access difficult because of the limited exposure of insular tumors. Hence, maximal and safe removal of insular gliomas is challenging. In this article, a new approach to resect insular gliomas is presented.

Revealing a peculiar supernova remnant G106.3+2.7 as a petaelectronvolt proton accelerator with X-ray observations.

Supernova remnants (SNRs) have long been considered as one of the most promising sources of Galactic cosmic rays. In the SNR paradigm, petaelectronvolt (PeV) proton acceleration may only be feasible at the early evolution stage, lasting a few hundred years, when the SNR shock speed is high. While evidence supporting the acceleration of PeV protons in young SNRs has yet to be discovered, X-ray synchrotron emission is an important indicator of fast shock.

Understanding the Multiwavelength Observation of Geminga's Tev Halo: The Role of Anisotropic Diffusion of Particles.

In this Letter, we propose that the x-ray and the TeV observations in the vicinity of Geminga can be understood in the framework of anisotropic diffusion of injected electrons or positrons. This interpretation only requires the turbulence in the vicinity of Geminga to be sub-Alfvénic with the local mean magnetic field direction approximately aligned with our line of sight towards Geminga, without invoking extreme conditions for the environment, such as an extremely small diffusion coefficient and a weak magnetic field of submicrogauss as suggested in previous literature.

Testing the Equivalence Principle and Lorentz Invariance with PeV Neutrinos from Blazar Flares.

It was recently proposed that a giant flare of the blazar PKS B1424-418 at redshift z=1.522 is in association with a PeV-energy neutrino event detected by IceCube. Based on this association we here suggest that the flight time difference between the PeV neutrino and gamma-ray photons from blazar flares can be used to constrain the violations of equivalence principle and the Lorentz invariance for neutrinos.

Phylogeographic surveys and apomictic genetic connectivity in the North Atlantic red seaweed Mastocarpus stellatus.

The North Atlantic red alga Mastocarpus stellatus is characterized by two life histories (sexual-type and direct-type), which correspond to two geographically isolated breeding groups. These features enable M. stellatus to be an interesting model to investigate how environmental shift and apomictic propagation have influenced its population genetic structure, historical demography and distribution dynamic.

The genetic diversity of mtDNA D-loop and the origin of Chinese goats.

The complete sequences of mitochondrial DNA D-loop of 128 individuals in nine Chinese goat (Capra hircu) breeds were analyzed by DNA sequencing technology. The results show that the length of mtDNA D-loop in Chinese goats is 1,212-1,213 bp. There are 102 polymorphic sites, accounting for 8.

[Genetic diversity of mitochondrial DNA D-loop sequences in cattle breeds in Guizhou].

The complete mitochondrial D-loop sequences, 910 bp in length, in 82 individual cattle from 4 breeds in Guizhou province were analyzed. The results revealed 31 mitochondrial haplotypes, 65 polymorphic sites, covering 7.14% of the entire length of the sequence.