Publications by authors named "Ruo-Nan Gu"
J Neuroinflammation
June 2019
Article Synopsis
- The NLRP3 inflammasome is an important part of the immune system that helps regulate inflammation and is linked to conditions like stroke and diabetes.
- Recent research suggests that targeting and inhibiting the NLRP3 inflammasome could reduce inflammation and improve outcomes for patients with both ischemic stroke and diabetes.
- This approach offers a potential new treatment strategy for managing these interconnected diseases by preventing activation of harmful cytokines that worsen organ injury.
Neural Plast
November 2018
Article Synopsis
- The study investigates the role of the NLRP3 inflammasome in diabetic mice experiencing stroke through a model of cerebral ischemia-reperfusion injury.
- Diabetic mice treated with MCC950, an NLRP3 inhibitor, showed reduced neurological deficits and improved survival rates following a stroke compared to those who did not receive the treatment.
- Increased levels of NLRP3, IL-1, and caspase-1 were observed in the ischemic area of diabetic mice, but pre-treatment with MCC950 significantly lowered these levels, suggesting that NLRP3 inflammasome plays a critical role in the relationship between diabetes and stroke.
