Acid-sensing ion channel 3 is required for agmatine-induced histamine-independent itch in mice.

Introduction: Itch is a common symptom of many skin and systemic diseases. Identifying novel endogenous itch mediators and the downstream signaling pathways involved will contribute to the development of new strategies for the treatment of chronic itch. In the present study, we adopted behavioral testing, patch clamp recording and metabonomics analysis to investigate the role of agmatine in itch and the underlying mechanism.

[Impacts of land-use types on soil C mineralization and temperature sensitivity of forests in Qianyanzhou, Jiangxi Province, China].

Decomposition of soil organic matter plays an important role in the regulation of carbon (C) cycles at ecosystem or regional scales, and is closely related to temperature, moisture, and land-use types. The influences of soil temperature, moisture, and land-use types on soil C mineralization in Citrus reticulata and Pinus elliottii forests were investigated at the Qianyanzhou Ecological Experiment Station, Chinese Academy of Sciences, by conducting incubation experiments at 5-level temperatures (5, 10, 15, 20 and 25 degrees C) and 3-level moistures (30%, 60% and 90% saturated soil moisture, SSM). The results showed that soil temperature, moisture, and land-use types had significant effects on soil C mineralization and they had significant interaction effects.