MG-132 treatment promotes TRAIL-mediated apoptosis in SEB-1 sebocytes.

Aims: This study aimed to identify the mechanism of how MG-132 stimulates cell death in SEB-1 sebocytes.

Materials And Methods: TUNEL staining and annexin-FITC/PI flow cytometry were utilized to examine the apoptotic cell number of SEB-1 sebocytes and HaCaT keratinocytes upon MG-132 and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) treatment. MTT assay and CCK-8 assay monitored the proliferative rate and viability of both cell lines with different treatment.

Novel dithioether-silver(I) coordination architectures: structural diversities by varying the spacers and terminal groups of ligands.

An investigation into the dependence of the framework formation of coordination architectures on ligand spacers and terminal groups was reported based on the self-assembly of AgClO4 and eight structurally related flexible dithioether ligands, RS(CH2)nSR (Lan, R = ethyl group; Lbn, R = benzyl group, n= 1-4). Eight novel metal-organic architectures, [Ag(La1)3/2ClO4]n (1a), [Ag2(La2)2(ClO4)2]2 (2a), [AgLa3ClO4]n (3a), {[Ag(La4)2]ClO4}n (4a), [AgLb1ClO4]2 (1b), [Ag(Lb2)2]ClO4 (2b), {[Ag(Lb3)3/2(ClO4)1/2](ClO4)1/2}n (3b) and [Ag(Lb4)3/2ClO4]n(4b), were synthesized and structurally characterized by X-ray crystallography. Structure diversities were observed for these complexes: 1a forms a 2-D (6,3) net, while 2a is a discrete tetranuclear complex, in which the AgI ion adopts linear and tetrahedral coordination modes, and the S donors in each ligand show monodentate terminal and mu2-S bridging coordination fashions; 3a has a chiral helical chain structure in which two homo-chiral right-handed single helical chains (Ag-La3-)n are bound together through mu2-S donors, and simultaneously gives rise to left-handed helical entity (Ag-S-)n.

Novel eclipsed 2D cadmium(II) coordination polymers with open-channel structure constructed from terephthalate and 3-(2-pyridyl)pyrazole: crystal structures, emission properties, and inclusion of guest molecules.

Five new eclipsed two-dimensional (2D) coordination polymers, [[Cd(2)(TPT)(2)L(2)](GM(1))(3/2)(H(2)O)](infinity) (1) (TPT = terephthalate, L = 3-(2-pyridyl)pyrazole, GM(1) = terephthalic acid), [[Cd(TPT)L](GM(2))(H(2)O)(2)]( infinity) (2) (GM(2) = L = 3-(2-pyridyl)pyrazole), [[Cd(TPT)L](GM(3))(1/2)(H(2)O)](infinity) (3) (GM(3) = mesitylene), [[Cd(4)(TPT)(4)L(4)](GM(4))(7/2)](infinity) (4) (GM(4) = tetramethylbenzene), and [[Cd(TPT)L](GM(5))(1/2)](infinity) (5) (GM(5) = naphthalene), have been synthesized and characterized by X-ray diffraction. All the five complexes take the similar eclipsed 2D open-channel framework with different guest molecules included in the cavities of their channels. TGA analysis indicates that the eclipsed open-channel frameworks are thermally stable up to 300 degrees C.

Novel Cd(II) coordination polymers with flexible disulfoxide ligands: effects of ligand spacers, terminal groups and counter anions on the complex framework formations.

Five novel Cd(II) coordination polymers with three structurally related flexible disulfoxide ligands, [[Cd(L1)3](ClO4)2]n (1), [[Cd(L2)3](ClO4)2(CHCl3)]n (2), [Cd(L2)(NO3)2(H2O)]n (3), [Cd2(L3)2(NO3)4]n (4) and [[Cd(L3)3](ClO4)2]n (5), where L1= 1,3-bis(phenylsulfinyl)propane, L2= 1,4-bis(phenylsulfinyl)butane and L3= 1,4-bis(ethylsulfinyl)butane, were synthesized and structurally determined by X-ray diffraction. Complex 1 has a 2D layer structure, in which part of the L1 ligands bridge the Cd(II) ions to form double-bridging chains and the other part of ligands link such chains to form a 2D framework. Complexes 2 and 5 are isomorphous, showing unusual 2D (3,6) network structures containing triangular grids.

Novel lanthanide coordination polymers with a flexible disulfoxide ligand, 1,2-bis(ethylsulfinyl)ethane: structures, stereochemistry, and the influences of counteranions on the framework formations.

The reactions of meso-1,2-bis(ethylsulfinyl)ethane (meso-L) with Ln(ClO(4))(3) [Ln(NO(3))(3) or Ln(NCS)(3)] in MeOH and CHCl(3) gave a series of new lanthanide coordination polymers, [[Ln(micro-meso-L)(rac-L)(2)(CH(3)OH)(2)](ClO(4))(3)](n) [Ln: La (1), Nd (2), Eu (3), Gd (4), Tb (5), Dy (6), and Yb (7)], [Yb(micro-meso-L)(1.5)(NO(3))(3)](n) (8), and [La(micro-meso-L)(2.5)(NCS)(3)](n) (9).

Adjusting the frameworks of silver(I) complexes with new pyridyl thioethers by varying the chain lengths of ligand spacers, solvents, and counteranions.

In our efforts to systematically investigate the effects of the linker units of flexible ligands and other factors on the structures of Ag(I) complexes with thioethers, five new flexible pyridyl thioether ligands, bis(2-pyridylthio)methane (L(1)()), 1,3-bis(2-pyridylthio)propane (L(3)()), 1,4-bis(2-pyridylthio)butane (L(4)), 1,5-bis(2-pyridylthio)pentane (L(5)), and 1,6-bis(2-pyridylthio)hexane (L(6)), have been designed and synthesized, and the reactions of these ligands with Ag(I) salts under varied conditions (varying the solvents and counteranions) lead to the formation of eight novel metal-organic coordination architectures from di- and trinuclear species to two-dimensional networks: [Ag(3)(L(1)())(2)(ClO(4))(2)](ClO(4)) (1), [[AgL(3)](ClO(4))]( infinity ) (2), [[Ag(2)(L(4))(2)](ClO(4))(2)(CHCl(3))]( infinity ) (3), [[AgL(4)](ClO(4))(C(3)H(6)O)]( infinity ) (4), [[Ag(2)L(4)](NO(3))(2)]( infinity ) (5), [Ag(2)L(4)()(CF(3)SO(3))(2)]( infinity ) (6), [[AgL(5)](ClO(4))(CHCl(3))](2) (7), and [[AgL(6)()](ClO(4))]( infinity ) (8). All the structures were established by single-crystal X-ray diffraction analysis. The coordination modes of these ligands were found to vary from N,N-bidentate to N,N,S-tridentate to N,N,S,S-tetradentate modes, while the Ag(I) centers adopt two-, three-, or four-coordination geometries with different coordination environments.

Controlling the framework formation of silver(I) coordination polymers with 1,4-bis(phenylthio)butane by varying the solvents, metal-to-ligand ratio, and counteranions.

The reactions of 1,4-bis(phenylthio)butane (L) with Ag(I) salts in varied conditions (varying the solvents, metal-to-ligand ratios, and counteranions) lead to the formation of four new two-dimensional (2D) coordination polymers with different network structures: [Ag(2)L(3)(ClO(4))(2)](infinity) 1, [Ag(2)L(3)(ClO(4))(2) x CH(3)OH](infinity) 2, [[AgL(2)](ClO(4))](infinity) 3, and [AgLNO(3)](infinity) 4. All the structures were established by single-crystal X-ray diffraction analysis. Crystal data for 1: triclinic, P-1, a = 11.

Flexible meso-Bis(sulfinyl) Ligands as Building Blocks for Copper(II) Coordination Polymers: Cavity Control by Varying the Chain Length of Ligands.

Fillings and cavities: Three novel pseudo-octahedral metal-organic frameworks, 1-3, consisting of macrometallacyclic noninterpenetrating meso networks and exhibiting weak antiferromagnetic interactions, have been constructed from Cu centers and structurally flexible R,S-bis(sulfinyl) ligands. Varying the chain length of ligands is found to control the cavity sizes of the networks.