Publications by authors named "Ruo-Hong Shui"
Article Synopsis
- A phase II trial was conducted to evaluate the efficacy and safety of a new neoadjuvant chemoimmunotherapy regimen combining chemotherapy with the PD-1 antibody toripalimab for early-stage triple-negative breast cancer (TNBC).
- The study included 70 female patients with stage II-III TNBC, who received a combination of standard chemotherapy and immunotherapy, with primary endpoints focusing on total and breast pathological complete response rates.
- Results showed that over half of the participants achieved tumor response, with some experiencing manageable side effects, indicating that this treatment combination is promising and worthy of further research.
Aims: Human epidermal growth factor receptor 2 (HER2)-positive patients with breast cancer may have different HER2/CEP17 ratios and HER2 copy numbers, with inconsistent responses to anti-HER2 neoadjuvant chemotherapy (NACT). Our study aimed to explore the relationship between different HER2 fluorescence in situ hybridisation (FISH) patterns in HER2-positive patients with breast cancer and responses to anti-HER2 NACT.
Methods: 527 patients with HER2-positive invasive breast cancer who received anti-HER2 NACT from 2015 to 2022 were included and divided into three groups by FISH results, namely group A: HER2/CEP17<2.
Background: Triple-negative breast cancers display heterogeneity in molecular drivers and immune traits. We previously classified triple-negative breast cancers into four subtypes: luminal androgen receptor (LAR), immunomodulatory, basal-like immune-suppressed (BLIS), and mesenchymal-like (MES). Here, we aimed to evaluate the efficacy and safety of subtyping-based therapy in the first-line treatment of triple-negative breast cancer.
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- Tumor-infiltrating lymphocytes (TILs) and PD-L1 are not always reliable indicators of clinical outcomes in triple-negative breast cancer, as their expression can be influenced by unexamined genomic and transcriptomic changes.
- The study analyzed PD-L1 scores and TIL levels across multiple datasets and clinical trials, uncovering that specific genomic alterations relate to unexpected patient outcomes, including a paradoxical relationship between TILs and PD-L1 expression.
- Researchers categorized triple-negative breast cancers into four groups based on TIL and PD-L1 levels, finding that certain combinations (like TIL-negative PD-L1-positive) were linked to poorer prognoses and reduced effectiveness of immunotherapy.
Article Synopsis
- The study looked at a type of cancer called Large B-cell lymphoma with IRF4 rearrangement (LBCL, IRF4+) in young patients and found it usually leads to better outcomes.
- Researchers reviewed 100 cases of this cancer in young people, focusing on tumor characteristics, treatment methods, and patient survival rates.
- They discovered that patients with IRF4+ had higher chances of recovery and survival, suggesting that IRF4+ is an important factor for understanding and treating this cancer.
Estrogen receptor-low breast cancer: Biology chaos and treatment paradox.
Cancer Commun (Lond)
October 2021
Hormone receptor testing mainly serves the purpose of guiding treatment choices for breast cancer patients. Patients with estrogen receptor (ER)-positive breast cancers show significant response to endocrine therapy. However, the methods to define ER status and eligibility for treatment remain controversial.
View Article and Find Full Text PDFBackground: Anaplastic large cell lymphoma (ALCL) with uniform CD56 expression is a rare condition, that has been described in limited literature, and its clinicopathological features have not yet been well illustrated. The aim of our study was to fully investigate the clinical, histological, immunohistochemical and molecular features of CD56+ ALCL.
Methods: The clinical and histological characteristics of CD56+ ALCL cases were retrospectively evaluated.
Aims: To fully elucidate the clinicopathological features of breast carcinoma in sclerosing adenosis (SA-BC).
Methods: Clinical and histological characteristics of 206 SA-BCs from 180 patients were retrospectively evaluated. Immunohistochemical phenotype was examined.
Purpose: To investigate the clinicopathological features, survival and prognostic factors of primary intestinal extranodal natural killer/T-cell lymphoma, nasal type (PI-ENKTCL).
Methods: Clinical and histological characteristics of PI-ENKTCL cases were retrospectively evaluated. Immunohistochemical phenotype and status of Epstein-Barr virus (EBV) and T-cell receptor (TCR) gene rearrangement were examined.
Purpose: A lack of progesterone receptor (PgR) expression in oestrogen receptor-positive (ER+) tumours is associated with worse survival. PgR status is usually defined as positive or negative using 1% positive nuclei as a cut-off point. In this study, we aimed to assess the clinicopathologic characteristics of ER+/PgR-/HER2- tumours by comparing them with ER+/PgR+/HER2- tumours using a PgR cut-off point of 20% as a divisive criterion.
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- Cathepsin B (CB) helps break down proteins and is important for how cells work normally.
- In a study, they found that CB is higher in the muscles of people with polymyositis/dermatomyositis (PM/DM), which can also lead to lung problems.
- They tested a special treatment on guinea pigs and saw that blocking CB helped reduce lung inflammation and scarring caused by PM, showing that CB plays a big role in these lung issues.
Article Synopsis
- The study looked at a rare type of breast tumor called microglandular adenosis and its different forms, including early and advanced stages of cancer.
- They analyzed three cases using special tests to see how the tumor cells looked and acted.
- The findings showed that this tumor has unique characteristics, and more research is needed to understand how it behaves in patients.
[Immunohistochemical study using T-cell lymphoma antibody 1 and CD44 in diagnosis of Burkitt's lymphoma].
Zhonghua Bing Li Xue Za Zhi
November 2009
Objective: To study the values of immunohistochemistry using T-cell lymphoma antibody (TCL) 1 and CD44 in the diagnosis of Burkitt's lymphoma.
Methods: Immunohistochemical study for TCL1, CD44, CD10, bcl-2, bcl-6, c-myc and Ki-67 was performed on paraffin-embedded sections of lymphoma cases, including 25 cases of Burkitt's lymphoma and 25 cases of diffuse large B-cell lymphoma.
Results: Burkitt's lymphoma commonly expressed TCL1 (96%, 24 cases), CD10 (88%, 22 cases), bcl-6 and c-myc (92%, 23 cases).
Article Synopsis
- The study investigates genetic abnormalities and their implications in follicular lymphoma (FL), focusing on tissue samples from FL, other small B-cell lymphomas, and reactive follicular hyperplasia.
- It employs techniques like nested PCR and FISH to analyze the presence of clonal immunoglobulin heavy chain gene rearrangements and specific translocations (t (14; 18)).
- Findings reveal that FL has a lower detection rate of clonal IgH rearrangement compared to other lymphomas, with FISH proving to be more effective in identifying the significant genetic translocation in the samples examined.
Objective: To investigate the feasibility of detecting cyclin D1 mRNA in paraffin-embedded tissues by reverse transcriptase polymerase chain reaction (RT-PCR) and competitive RT-PCR and its diagnostic and differential diagnostic significance for mantle cell lymphoma (MCL).
Methods: Paraffin-embedded samples of 36 cases of MCL, 71 cases of other small B-cell lymphomas and 20 cases of lymphoid reactive hyperplasia as control group were retrieved from archival materials. Cyclin D1 protein and its mRNA was detected by EnVision and RT-PCR and competitive RT-PCR in all samples.
Objective: To explore the feasibility of detecting FUS-CHOP fusion gene in formalin-fixed, paraffin-embedded tissue and its application in the diagnosis and differential diagnosis of myxoid/round cell liposarcomas (MRCLs).
Methods: Forty-four formalin-fixed, paraffin-embedded MRCL samples and 60 control cases (atypical/well-differentiated liposarcoma, pleomorphic liposarcoma, low-grade myofibrosarcoma, etc.) retrieved from the archival files were studied.
Objective: To investigate the feasibility of detecting cyclin D1 protein expression and t(11;14) chromosomal translocation in paraffin-embedded tissues and its diagnostic and differential diagnostic significance for mantle cell lymphoma (MCL).
Methods: Paraffin-embedded samples of 36 cases of MCL and a control group of 71 cases of small B-cell lymphomas were retrieved from archive materials. Immunohistochemical staining for cyclin D1 and semi-nested PCR for t(11;14) were detected in all samples.