Design, Synthesis and Bioactivity of Benzyl Propiolates with Broad-Spectrum Inhibition Activity on Phytopathogenic Fungi.

As part of our continuing research on propiolic acid derivatives, a series of benzyl propiolate derivatives and analogues were designed, synthesized, and investigated for inhibition activity and on phytopathogenic fungi, structure-activity relationship (SAR) and action mechanism. The results showed that most of the compounds had potent and broad-spectrum antifungal activity at 50 μg/mL. Among the compounds, 2-bromobenzyl propiolate () displayed the highest comprehensive activity with total activity index (TAI) of 4.