ASF1B promotes gastric cancer progression by modulating H2AC20 and activating PI3K/AKT and ERK1/2 pathways.

Background: Gastric cancer (GC) ranks among the most prevalent malignant neoplasms globally and is associated with a significant mortality rate. Despite the availability of various therapeutic interventions for GC, the overall prognosis for this disease remains unfavorable. This can be attributed to several factors, including delayed diagnosis and the inherent heterogeneity of the tumors.

Association between GLP-1 RAs and DPP-4 inhibitors with biliary disorders: pharmacovigilance analysis.

Background And Aims: Incretin-based therapies, including glucagon-like peptide 1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors, are essential treatments in diabetes management due to their efficacy in glycemic control and the additional benefits of GLP-1 RAs, which include cardiovascular and renal protection. However, concerns about potential associations with biliary disorders necessitate ongoing pharmacovigilance. This study analyzes the link between these drugs and biliary adverse events (AEs) using the FDA Adverse Event Reporting System (FAERS) to enhance clinical safety.

Frequency-Dependent Changes in Wavelet-ALFF in Patients With Acute Basal Ganglia Ischemic Stroke: A Resting-State fMRI Study.

Motor impairment is a common occurrence in patients with acute basal ganglia (BG) ischemic stroke (ABGIS). However, the underlying mechanisms of poststroke motor dysfunction remain incompletely elucidated. In this study, we employed multifrequency band wavelet transform-based amplitude of low-frequency fluctuations (Wavelet-ALFFs) to investigate the alterations of spontaneous regional neural activity in patients with ABGIS.

BDNF is a prognostic biomarker involved in the immune infiltration of lung adenocarcinoma and associated with programmed cell death.

It is well established that genes associated with cell death can serve as prognostic markers for patients with cancer. Programmed cell death (PCD) is known to play a role in cancer cell apoptosis and antitumor immunity. With the continuous discovery of new forms of PCD, the roles of PCD in lung adenocarcinoma (LUAD) require ongoing evaluation.

Tumor‑stroma ratio as a clinical prognostic factor in colorectal carcinoma: A meta‑analysis of 7,934 patients.

The tumor-stroma ratio (TSR) has been regarded as an important factor associated with tumor metastasis, based on the 'seed and soil' theory, which may have guiding significance for the selection of chemotherapy regimens. Therefore, a high TSR may be a new risk factor for tumor recurrence in patients with stage II colorectal cancer (CRC). The present study aimed to evaluate the prognostic value of TSR in CRC, especially for the computer-calculated TSR.

Systematic review and meta‑analysis of factors predicting postoperative lung function after lung cancer resection.

Introduction: Lung resection continues to be the most effective treatment for early‑stage lung cancer. Prediction of postoperative lung function is particularly important when evaluating patient eligibility for surgery, as it helps assess the likelihood of experiencing difficulty breathing after the operation.

Aim: We aimed to identify the most common methods used to predict postoperative lung function in clinical practice and to compare their accuracy.

Printability in Multi-material Projection-Based 3-Dimensional Bioprinting.

Accurately reconstructing the intricate structure of natural organisms is the long-standing goal of 3-dimensional (3D) bioprinting. Projection-based 3D printing boasts the highest resolution-to-manufacturing time ratio among all 3D-printing technologies, rendering it a highly promising technique in this field. However, achieving standardized, high-fidelity, and high-resolution printing of composite structures using bioinks with diverse mechanical properties remains a marked challenge.

Adduct-catalyzed tandem electro-thermal synthesis of organophosphorus (III) compounds from white phosphorus.

Electrooxidation strategies for synthesizing readily oxidizable products face notable challenges, especially when the oxidation potential of the products is lower than that of the reactants or when high current densities are necessary. The electrooxidation synthesis of trivalent organophosphorus compounds (OPCs (III)) from white phosphorus (P) has demonstrated potential but is hindered by selectivity issues due to over-oxidation. Herein, we report a tandem electro-thermal synthesis pathway that addresses these challenges in producing OPCs (III) from P.

Effects of irrigation frequency on root growth, nutrients accumulation, yield, and water use efficiency of under micro-sprinkler irrigation.

Micro-sprinkler irrigation has been a promising irrigation method to promote (Burk) F. H. Chen production but their scientific irrigation frequency in improving yield and water use efficiency of remains contradictory and inconclusive.

Ensiling characteristics, digestibility and bacterial community structure of mulberry leaf silage with or without the addition of cellulase, protease, and starch.

Objective: This study aimed to investigate the effects of cellulase, protease, and starch on the fermentation quality, digestibility, and microbial community of mulberry leaf silage after 30d of ensiling.

Methods: Mulberry leaves (376 g/kg dry matter (DM)) were ensiled with four experimental treatments: i) CON, no additives; ii) CEL, added cellulase (120 U/g fresh matter [FM]); iii) CPR, added cellulase (120 U/g FM) and protease (50 U/g FM); and iv) CPS, added cellulase (120 U/g FM), protease (50 U/g FM), and starch (2% FM).

Results: All treatments with additives improved fermentation quality, showing higher DM (353 ~ 378 vs.

Viscoelastic Hydrogel Promotes Disc Mechanical Homeostasis Repair and Delays Intervertebral Disc Degeneration via the Yes-Associated Protein Pathway.

Intervertebral disc degeneration (IDD) process is accompanied by overactive inflammation and mechanical instability of the nucleus pulposus (NP). Current treatments do not fully restore the biomechanical environment of discs, limiting their therapeutic efficacy. Thus, novel strategies are required to combat IDD.

Joint association of sleep onset time and sleep duration with depression in patients with chronic kidney disease: Insights from the NHANES 2015-2020.

Background: The prevalence of depression among patients with chronic kidney disease (CKD) is high and closely related to poor prognosis. However, the association between sleep onset time, sleep duration, and depression in CKD patients has not been thoroughly studied.

Methods: This study utilized cross-sectional data from CKD patients who participated in the National Health and Nutrition Examination Survey from 2015 to 2020, analyzing their sleep onset time, sleep duration, and Patient Health Questionnaire-Nine.

Integrated molecular characterization reveals the pathogenesis and therapeutic strategies of pulmonary blastoma.

Background: Pulmonary blastoma (PB) is a rare subtype of lung cancer. Currently, the underlying pathogenesis mechanisms of PB have not been fully illustrated, and the therapeutic approach for this entity is limited.

Methods: Whole-exome sequencing (WES), RNA sequencing, and DNA methylation profiling are applied to seven PB patients.

Dezocine modulates the reinstatement of conditioned place preference in morphine-dependent rats via the dopamine reward circuitry.

Introduction: Opioid addiction is a significant public health issue, with existing treatments such as buprenorphine and methadone exhibiting limitations, including side effects and insufficient prevention of relapse. Novel therapeutic strategies are needed to address these challenges. This study investigates the potential of dezocine in reducing addiction-related behaviors and preventing relapse.

Direct synthesis of high quantum yield lead-free CsCuI powder in water and its application in yellow LED.

Yellow light-emitting diodes (LEDs) with a wavelength of 570-590 nm can reduce the excitability of peripheral nerves and the sensitivity of the skin, stimulate collagen synthesis, and tighten the skin, which plays an important role in skin rejuvenation. In general, commercial LEDs are made of phosphor excited by ultraviolet chips. It is very important for the development of yellow light emitters with high luminous efficiency, good stability, and environmental protection.

Limiting tourniquet use during total knee arthroplasty improves short-term postoperative outcomes in patients with hypertension.

Introduction: Tourniquets are commonly used during total knee arthroplasty (TKA) to reduce intraoperative bleeding. However, information on the optimal tourniquet usage strategy in patients with hypertension are lacking.

Methods: A retrospective analysis of 90 patients with knee osteoarthritis and hypertension who underwent primary TKA was conducted.

Thermo-sensitive ε-polylysine-heparin-poloxamer hydrogel-encapsulated BMSCs promote endometrial regeneration.

Endometrium plays a key role in embryo implantation and maintenance of pregnancy. However, to repair endometrial injury is still a challenge. In recent years, hydrogel materials have been widely used as effective support matrices to prevent intrauterine adhesions after endometrial injury.

A new attempt to treat Ellman III PASTA lesions: arthroscopic side-to-side anastomosis of longitudinal split tendon.

To investigate the surgical method and therapeutic effect of longitudinal tendon splitting and side-to-side anastomosis on Ellman III partial articular supraspinatus tendon avulsion (PASTA) lesions under arthroscope. Thirty-two patients with Ellman III PASTA lesions were treated with the method. Joint range of motion, Visual Analogue Score (VAS), University of California at Los Angeles (UCLA), and American Shoulder and Elbow Surgeons (ASES) scores were recorded and compared before surgery and at the last follow-up, and postoperative pain and functional improvement were comprehensively evaluated.

CAMTA1-immunonegative epithelioid hemangioendotheliomas of the liver: a clinicopathological and molecular analysis of seven cases.

Background: Epithelioid hemangioendothelioma (EHE) is a rare malignant vascular tumor. Most EHEs (>90%) cases harbor fusion gene, and CAMTA1 immunohistochemistry (IHC) is a highly sensitive and specific tool for EHE diagnosis. However, there exist CAMTA1-immunonegative cases, the majority of which harbor fusion, with a few cases having more rare fusions.

Analysis of tumor-infiltrating exhausted T cells highlights IL-6 and PD1 blockade as a combined immunotherapy strategy for non-small cell lung cancer.

Objective: Given the limitations of immunotherapy for treating non-small cell lung cancer (NSCLC), we investigated the phenotype and function of exhausted CD8T cells and analyzed a novel combination immunotherapy to restore the effector killing function of tumor-infiltrating CD8T lymphocyte (TIL).

Methods: We examined the expression and function of immunosuppressive molecules on CD8T cells of peripheral blood mononuclear cells (PBMCs) and TILs by using prospectively collected peripheral blood, pleural effusions, and tumor tissues from patients with NSCLC and correlated the results with clinical data. We then evaluated the effect of interleukin 6 (IL-6) stimulation on CD8T cells.

Similarities and differences of a proliferation-inducing ligand expression in lacrimal gland lesions of patients with IgG4-associated ophthalmic diseases and mucosa-associated lymphoid tissue lymphoma.

Objective: This study aimed to investigate the expression condition of a proliferation-inducing ligand (APRIL) in lacrimal gland lesions of patients with IgG4-associated ophthalmic diseases (IgG4-ROD) and mucosa-associated lymphoid tissue (MALT) lymphoma.

Patients And Methods: Fifteen patients with IgG4-ROD, 3 with MALT lymphoma, and 1 with elevated IgG4 with lacrimal gland lesions, treated in West China Hospital of Sichuan University from April 2022 to November 2023, were included. Immunofluorescence staining was used to detect the expression of APRIL in the specimen of lacrimal gland.

Mental Health Literacy and Professional Psychological Help-Seeking Attitudes Among Primary Healthcare Workers: The Mediating Role of Social Support and Mental Illness Stigma.

Background: Research highlights poor mental health among healthcare workers, but limited attention has been given to the mental health literacy and professional psychological help-seeking attitudes of primary healthcare workers.This study investigates the relationship between primary healthcare workers' mental health literacy and their attitudes toward professional psychological help-seeking. It also explores the chain mediating roles of social support and mental illness stigma in this relationship.

Schwann cell-derived exosomes accelerate periodontal bone regeneration with osteogenesis, angiogenesis, and neurogenesis.

Severe periodontitis frequently leads to irreversible degradation of alveolar bone. Periodontal regeneration techniques hold immense potential in reconstructing alveolar bone post periodontal diseases. Schwann cells (SCs) play a critical role in supporting, maintaining, and regenerating periodontal tissues, with SC-derived exosomes (SC-EXO) exhibiting cell homing and tissue repair capabilities.