Contrast-induced acute kidney injury (CIAKI) is a common complication with limited treatments. Intermedin (IMD), a peptide belonging to the calcitonin gene-related peptide family, promotes vasodilation and endothelial stability, but its role in mitigating CIAKI remains unexplored. This study investigates the protective effects of IMD in CIAKI, focusing on its mechanisms, particularly the cAMP/Rac1 signaling pathway.
View Article and Find Full Text PDFBackground: Bile acids (BAs), products of gut microbiota metabolism, have long been implicated in atherosclerotic disease pathogenesis. Characterizing the serum bile acid profile and exploring its potential role in carotid atherosclerosis (CAS) development are crucial tasks.
Methods: In this study, we recruited 73 patients with CAS as the disease group and 77 healthy individuals as the control group.
ACS Appl Mater Interfaces
March 2022
Concerns about thermal safety and unresolved high-voltage stability have impeded the commercialization of high-energy lithium-ion batteries bearing LiNiCoMnO (NCM811) cathodes. Enhancing the cathode structure and optimizing the electrolyte formula have demonstrated significant potential in improving the high-voltage properties of batteries while simultaneously minimizing thermal hazards. The current study reports the development of a high-voltage lithium-ion battery that is both safe and reliable, using single-crystal NCM811 and a dual-salt electrolyte (DSE).
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