Publications by authors named "Runwen Qin"
Effects of Nicotine Doses and Administration Frequencies on Mouse Body Weight and Adipose Tissues.
Nicotine Tob Res
September 2024
Article Synopsis
- This study explores how varying doses and administration frequencies of nicotine influence body weight, fat tissues, and liver health in male mice.
- Mice were given nicotine in different doses (0.5mg/kg, 1mg/kg, or 2mg/kg) either once, twice, or four times a day for four weeks, and their body and fat tissue weights were measured.
- Results showed that nicotine reduced body weight and fat tissue size more effectively with increased administration frequency, particularly finding that 2mg/kg given twice daily was the most effective for weight loss while revealing complex effects on different fat tissue types.
Cytochrome P450 1A2 (CYP1A2) is a known tumor suppressor in hepatocellular carcinoma (HCC), but its expression is repressed in HCC and the underlying mechanism is unclear. In this study, we investigated the epigenetic mechanisms of CYP1A2 repression and potential therapeutic implications. In HCC tumor tissues, the methylation rates of CpG island (CGI) and DNA methyltransferase (DNMT) 3A protein levels were significantly higher, and there was a clear negative correlation between DNMT3A and CYP1A2 protein expression.
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