Publications by authors named "Runmei Xu"
Transdermal drug delivery system (TDDS) was an effective way to realize controlled drug delivery. However, realizing zero-order controlled drug skin delivery was still challenging in the drug-in-adhesive patch. This study provided a strategy to accomplish this delivery form by stabilizing the drug concentration in adhesive through concentration-dependent competitive interaction.
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- - Researchers investigated modifications to Combretastatin A-4 (CA-4) to enhance its low solubility and improve its effectiveness as a cancer treatment.
- - They found that adding a piperazine ring significantly increased the solubility of CA-4 derivatives, with some compounds showing solubility improvements of 230 to 2494 times compared to the control.
- - The new compounds demonstrated strong anticancer activity against various cancer cell lines, with one compound showing an IC50 value of 20 nM against HCT-116 cells, indicating potential for drug development due to its good plasma stability and moderate protein binding.