Publications by authors named "Runkang Qu"
Avian influenza virus (AIV) can evolve multiple strategies to combat host antiviral defenses and establish efficient infectivity in mammals, including humans. H9N2 AIV and its reassortants (such as H5N6 and H7N9 viruses) pose an increasing threat to human health; however, the mechanisms involved in their increased virulence remain poorly understood. We previously reported that the M1 mutation T37A has become predominant among chicken H9N2 isolates in China.
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- H9N2 avian influenza virus is crucial for creating genetic variations in other co-circulating influenza viruses, potentially leading to new strains that can infect humans.
- Prior to the significant H7N9 epidemic in 2016-2017, H9N2 viruses mutated and became more common, even in vaccinated chickens, which contributed to the emergence of a dominant H7N9 genotype with heightened human infectivity.
- The study underscores the public health risks posed by H9N2 due to its role in the continuous mutation and reassortment of viruses, increasing the likelihood of zoonotic infections.