[Value of the deep learning automated quantification of tumor-stroma ratio in predicting efficacy and prognosis of neoadjuvant therapy for breast cancer based on residual cancer burden grading].

To investigate the prognostic value of deep learning-based automated quantification of tumor-stroma ratio (TSR) in patients undergoing neoadjuvant therapy (NAT) for breast cancer. Specimens were collected from 209 breast cancer patients who received NAT at Renmin Hospital of Wuhan University from October 2019 to June 2023. TSR levels in pre-NAT biopsy specimens were automatically computed using a deep learning algorithm and categorized into low stroma (TSR≤30%), intermediate stroma (TSR 30% to ≤60%), and high stroma (TSR>60%) groups.

[Aggressive mucinous tubular and spindle cell carcinoma of the kidney: a clinicopathological and genetic analysis of four cases].

To understand the clinicopathological and molecular genetic characteristics of aggressive renal mucinous tubular and spindle cell carcinoma (MTSCC). The clinical features, histology, immunophenotype, molecular characteristics and prognosis of 4 cases of metastatic/recurrent renal MTSCC that were submitted to the Peking University Third Hospital (2 cases), Institute of Urology, Peking University (one case) and Zhejiang Provincial People's Hospital (one case) from 2015 to 2020 were retrospectively reviewed and analyzed. Among the four patients, two were male and two were female.

Optineurin Cooperates With NRF2 to Regulate Tooth Root Morphogenesis by Controlling Mitochondrial Dynamics and Apoptosis.

Tooth root development is a complex process essential for tooth function, yet the role of root dentin development in tooth morphogenesis is not fully understood. Optineurin (OPTN), linked to bone disorders like Paget's disease of bone (PDB), may affect tooth root development. In this study, we used single-cell sequencing of embryonic day 16.

Nitro-oleic acid alleviates inflammation and fibrosis by regulating macrophage polarization and fibroblast activation to improve cardiac function in MI mice.

Chronic heart failure, caused by myocardial fibrosis after acute myocardial infarction (AMI), remains a serious clinical problem that needs urgent resolution. Nitro-oleic acid (OA-NO), an electrophilic nitro-fatty acid found in human plasma, is believed to regulate various pathophysiological functions, particularly anti-inflammation and anti-fibrosis. However, the role of OA-NO in AMI remains unexplored.

Relationship between social support and depressive symptoms among internal migrant workers and the mediating role of healthy lifestyle: a cross-sectional study in China.

Objectives: To investigate the association between social support and depressive symptoms among internal migrant workers with a focus on the mediating role of a healthy lifestyle.

Design: Cross-sectional study.

Setting: The research was conducted among internal migrant workers in Henan Province, China, in August 2023.

GP73 reinforces cytotoxic T-cell function by regulating HIF-1α and increasing antitumor efficacy.

Background: Immunotherapy that targets immune checkpoints has achieved revolutionary success, but its application in solid tumors remains limited, highlighting the need for reliable enhancement of the efficacy of immunotherapy. Golgi protein 73 (GP73), a Golgi membrane protein, has been implicated in various cellular processes, including immune regulation. Recent studies suggested that GP73 may play a role in modulating the immune response in patients with cancer.

CREB3L1 facilitates pancreatic tumor progression and reprograms intratumoral tumor-associated macrophages to shape an immunotherapy-resistance microenvironment.

Background: To date, a growing body of evidence suggests that unfolded protein response (UPR) sensors play a vital role in carcinogenesis. However, it remains unclear whether they are involved in pancreatic ductal adenocarcinoma (PDAC) and how they relate to clinical outcomes. This study aims to investigate the biological function and mechanism of how a novel UPR sensor, CREB3L1 works in PDAC and further evaluate its clinical application prospect.

Hierarchical architecture of neo-sex chromosomes and accelerated adaptive evolution in tortricid moths.

Sex chromosomes can expand through fusion with autosomes, thereby acquiring unique evolutionary patterns. In butterflies and moths (Lepidoptera), these sex chromosome-autosome (SA) fusions occur relatively frequently, suggesting possible evolutionary advantages. Here, we investigated how SA fusion affects chromosome features and molecular evolution in leafroller moths (Lepidoptera: Tortricidae).

Pre-operative ultrasound localization of misdiagnosed foreign object as verruca vulgaris: a case report.

Aim: Verruca vulgaris is a common skin disease among children. Foreign object mimicking a wart is unusual.

Methods: A report of a 6-year-old boy with foreign object misdiagnosed as verruca vulgaris.

Current advances and future prospects of blood-based techniques for identifying benign and malignant pulmonary nodules.

Lung cancer is the leading cause of cancer-related mortality worldwide, highlighting the urgent need for more accurate and minimally invasive diagnostic tools to improve early detection and patient outcomes. While low-dose computed tomography (LDCT) is effective for screening in high-risk individuals, its high false-positive rate necessitates more precise diagnostic strategies. Liquid biopsy, particularly ctDNA methylation analysis, represents a promising alternative for non-invasive classification of indeterminate pulmonary nodules (IPNs).

Turning the band alignment of carbon dots for visible-light-driven enzymatic asymmetric reduction of aromatic ketone.

Keto reductases are crucial NAD(P)H-dependent enzymes used for the enantioselective synthesis of alcohols from prochiral ketones. Typically, the NADPH cofactor is regenerated through a second enzyme and/or substrate. However, photocatalytic cofactor regeneration using water as a sacrificial electron and hydrogen donor presents a promising alternative, albeit a challenging one.

Genome-wide analysis of Class III peroxidase (PRX) family core genes and functional mechanism of GhPRXR1-A for seed development in Gossypium hirsutum.

Class III peroxidases (PRXs) play critical roles in plant growth and development by oxidizing various substrates with HO. Although many PRXs have been identified and their roles in biotic and abiotic stress responses have extensively investigated in plants. However, functional mechanisms of PRXs in seed development remain poorly understood.

Adipose ZFP36 protects against diet-induced obesity and insulin resistance.

Aims: Obesity, as a worldwide healthcare problem, has become more prevalent. ZFP36 is a well-known RNA-binding protein and involved in the posttranscriptional regulation of many physiological processes. Whether the adipose ZFP36 plays a role in obesity and insulin resistance remains unclear.

Removal of mixed antibiotics from saline wastewater under intermittent electrical stimulation and alterations of microbial communities and resistance genes.

Antibiotics and antibiotic resistance genes (ARGs) are severe refractory pollutants in water. However, the effect of an intermittent electrical stimulation on the removal of antibiotics and ARGs from saline wastewater remains unclear. An anaerobic-aerobic-coupled upflow bioelectrochemical reactors (AO-UBERs) was used to treat tetracyclines (TCs) and quinolones (QNs) in saline wastewater.

MtrAB two-component system is crucial for the intrinsic resistance and virulence of Mycobacterium abscessus.

Mycobacterium abscessus (Mab) poses serious therapeutic challenges, largely due to its intrinsic resistance to many antibiotics. The development of targeted therapeutic strategies necessitates the identification of bacterial factors that contribute to its reduced susceptibility to antibiotics and/or to the killing by its host cells. In this study, we discovered that Mab strains with disrupted mtrA, mtrB or both, or a gene-edited mtrA encoding MtrA with Tyr102Cys mutation, exhibited highly increased sensitivity to various drugs compared to the wild-type Mab.

Sustainable aviation fuel (SAF) from lignin: Pathways, catalysts, and challenges.

The aviation industry plays a crucial role in global trade and cultural exchange, but it faces significant challenges due to high fuel costs and environmental impacts. To achieve carbon neutrality, promoting the development of sustainable aviation fuel (SAF) is essential, with projections indicating that 65% of emissions reductions in the aviation industry by 2050 will come from the use of SAF. Lignin, as an abundant renewable resource, has great potential for conversion into aviation fuel components.

Identification of Biomarkers for Cervical Cancer Radiotherapy Sensitivity and Survival Prognosis.

Introduction Radiotherapy resistance leads to treatment failure and disease progression in patients with cervical cancer. This study aims to elucidate the molecular underpinnings of radiotherapy response in cervical cancer by identifying radiotherapy sensitivity genes (RSGs). Methods We utilized two GEO expression profiling datasets (GSE3578 and GSE6213) comprising cervical cancer biopsy samples taken before and during radiotherapy to identify differentially expressed genes (DEGs) using the RankProd meta-analysis approach.

Spectral heat flux redistribution upon interfacial transmission.

In nonmetallic crystals, heat is transported by phonons of different frequencies, each contributing differently to the overall heat flux spectrum. In this study, we demonstrate a significant redistribution of heat flux among phonon frequencies when phonons transmit across the interface between dissimilar solids. This redistribution arises from the natural tendency of phononic heat to re-establish the bulk distribution characteristic of the material through which it propagates.

Potential magnetic structure in Eu3InAs3 revealed by magnetization and thermodynamic study.

We systematically investigate the magnetization and thermodynamic responses associated with antiferromagnetic (AFM) transitions in single crystals of the magnetic semiconductor Eu3InAs3. The linear thermal expansion measurements around the AFM transition temperatures, TN1 and TN2, indicate an expansion along the a axis and contraction along the b and c axes. The calculated ∆V/V(T) shows a continuous change at TN, indicating a second-order magnetic phase transition.

The spin-wave energy spectrum and transition temperature of the two-dimensional VSe2-like: A retarded Green's function method study.

Based on the recent discovery of intrinsic magnetism in monolayer films VSe2, we have constructed a two-dimensional (2D) Heisenberg model incorporating the 1T and 2H structures. These configurations consist of three layers: the upper and lower surface layers and a middle layer. Using the retarded Green's function method, we investigate the spin-wave energy spectrum, spin-wave density of states, and transition temperature of the system.

Dispersive gains enhance wireless power transfer with asymmetric resonance.

Parity-time symmetry is a fundamental concept in non-Hermitian physics that has recently gained attention for its potential in engineering advanced electronic systems and achieving robust wireless power transfer even in the presence of disturbances, through the incorporation of nonlinearity. However, the current parity-time-symmetric scheme falls short of achieving the theoretical maximum efficiency of wireless power transfer and faces challenges when applied to non-resistive loads. In this study, we propose a theoretical framework and provide experimental evidence demonstrating that asymmetric resonance, based on dispersive gain, can greatly enhance the efficiency of wireless power transfer beyond the limits of symmetric approaches.

Development and evaluation of an in-beam PET system for proton therapy monitoring.

Objective: In-beam positron emission tomography (PET) has important development prospects in real-time monitoring of proton therapy. However, in the beam-on operation, the high bursts of radiation events pose challenges to the performance of the PET system.

Approach: In this study, we developed a dual-head in-beam PET system for proton therapy monitoring and evaluated its performance.

The NAC transcription factor LpNAC48 promotes trichome formation in Lilium pumilum.

Trichomes play a crucial role in plant resistance to abiotic and biotic stresses, and their development and characteristics vary across different species. This study demonstrates that trichomes of Lilium pumilum exhibit synchronized growth during flower bud differentiation and enhance the plant's adaptability to UV-B radiation and aphid infection. We identified LpNAC48, a NAC family transcription factor (TF), that interacted with the B-box (BBX) family TF LpBBX28, during trichome formation in L.