Publications by authors named "Run-Ze Ye"
Background And Objective: Accurate prediction of perioperative major adverse cardiovascular events (MACEs) is crucial, as it not only aids clinicians in comprehensively assessing patients' surgical risks and tailoring personalized surgical and perioperative management plans, but also for information-based shared decision-making with patients and efficient allocation of medical resources. This study developed and validated a machine learning (ML) model using accessible preoperative clinical data to predict perioperative MACEs in stable coronary artery disease (SCAD) patients undergoing noncardiac surgery (NCS).
Methods: We collected data from 9171 adult SCAD patients who underwent NCS and extracted 64 preoperative variables.
Background: Yezo virus (YEZV) is an emerging tick-borne pathogen, which was initially reported in Japan in 2021. Only one patient had been reported in China so far. We aimed to describe the epidemiological, clinical, and laboratory findings of a series of patients, and to characterise the viral genomes of YEZV.
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- Ticks are significant carriers of diseases that can affect both humans and animals, posing a growing health risk.
- In a field survey conducted in the Ningxia Hui Autonomous Region of China, researchers collected over 10,000 ticks from nine different species, noting how environmental factors influenced their distribution.
- The findings indicate specific areas in Ningxia are more suitable for certain tick species, highlighting the importance of these results for managing tick populations and controlling tick-borne illnesses, while also suggesting that future studies should explore how reforestation efforts impact tick dynamics.
Genomic characterization of an emerging isolated from tick eggs in northwestern China.
Emerg Microbes Infect
December 2024
Article Synopsis
- The emergence of Rickettsia barbariae, a tick-borne disease, has raised global concern since it was first detected in humans in Italy in 2008 and later in northwestern China.
- Researchers isolated the bacteria for the first time from tick eggs in China and sequenced its whole genome, giving it a modified name according to international standards.
- The genome analysis showed that this strain is closely related to other harmful rickettsiae, revealing its potential to be pathogenic and underscoring the need for better monitoring of tick-borne diseases in humans.
Article Synopsis
- Scientists discovered new viruses called Restviruses in the lungs of patients who were sick with a type of coronavirus.
- These Restviruses are similar to another group of viruses known as Statoviruses, which were found in the stomachs of animals.
- Researchers think that studying these new viruses could help us understand how they affect people's health and where they come from.
Article Synopsis
- - Recent research has identified a SARS-CoV-2-related virus, PCoV-GX/P2V, in pangolins, raising concerns about its potential to infect humans.
- - PCoV-GX/P2V can effectively replicate in human cells and causes serious lung issues in mice, indicating its pathogenicity.
- - Current immunity from SARS-CoV-2 may not protect against PCoV-GX/P2V, emphasizing the need for close monitoring to prevent cross-species transmission.
Article Synopsis
- * Researchers obtained the genome from metagenomic sequencing of an infected goat in China, revealing it has the smallest genome of its genus and indicating lower pathogenicity compared to similar species.
- * The study found a high infection rate of 79.3% in goats and noted significant genetic diversity, providing foundational insights for future studies and potential prevention strategies against this pathogen.
Background: Haemaphysalis concinna, carrying multiple pathogens, has attracted increasing attention because of its expanded geographical range and significant role in disease transmission. This study aimed to identify the potential public health risks posed by H. concinna and H.
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- Haemaphysalis longicornis, a type of tick, is becoming a concern because it's spreading and may carry diseases.
- Researchers studied 136 groups of these ticks and found 508 different RNA viruses, with 22 that no one had seen before.
- The study showed that the genetic differences in the ticks are linked to their environment, which helps us understand how viruses might spread from ticks to animals and people.
We recently detected a HKU4-related coronavirus in subgenus Merbecovirus (named pangolin-CoV-HKU4-P251T) from a Malayan pangolin. Here we report isolation and characterization of pangolin-CoV-HKU4-P251T, the genome sequence of which is closest to that of a coronavirus from the greater bamboo bat (Tylonycteris robustula) in Yunnan Province, China, with a 94.3% nucleotide identity.
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- Malaria cases in Niger skyrocketed from over 592,000 in 2000 to over 3 million in 2010, prompting a major public health response with various interventions, although their effectiveness requires further examination.
- A study conducted from 2010 to 2019 analyzed malaria data, revealing a decrease in incidence rates regionally, but with an increase in mortality and case fatality ratios in certain age groups, especially among 10-24 year olds.
- While some malaria interventions effectively reduced incidence rates, challenges persist in controlling mortality rates, indicating a need for improved surveillance, diagnosis, treatment, and preventive measures like insecticide-treated bed nets in Niger.
There has been increasing global concern about the spillover transmission of pangolin-associated microbes. To assess the risk of these microbes for emergence as human pathogens, we integrated data from multiple sources to describe the distribution and spectrum of microbes harbored by pangolins. Wild and trafficked pangolins have been mainly recorded in Asia and Africa, while captive pangolins have been reported in European and North American countries.
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- * The systematic review created a detailed database capturing the pathogen's distribution, prevalence, and genetic diversity through phylogenetic analyses, with A. capra found in 18 countries across Asia, Europe, and Africa.
- * The research indicated that domestic ruminants, especially goats and sheep, are primary hosts, with certain ticks like Haemaphysalis longicornis being key carriers, while habitat modeling identified optimal regions for A. capra mainly in Asia and eastern Europe.
Article Synopsis
- Anaplasma capra is a new tickborne bacteria identified in 2015 in China, impacting both humans and a variety of animals globally.
- Researchers sequenced the genomes of two A. capra strains from infected goats, finding that this species has the smallest genome in its genus.
- The study revealed high prevalence in goats, with the strains showing genetic similarities to those previously found in Asia and highlighting the genetic diversity of A. capra.
The seasonal human coronaviruses (HCoVs) have zoonotic origins, repeated infections, and global transmission. The objectives of this study are to elaborate the epidemiological and evolutionary characteristics of HCoVs from patients with acute respiratory illness. We conducted a multicenter surveillance at 36 sentinel hospitals of Beijing Metropolis, China, during 2016-2019.
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- A tick-borne protozoan poses a significant veterinary health threat to livestock and wildlife, with a limited number of genome sequences available until now.
- Researchers at Cheeloo College of Medicine sequenced the whole genome of a new strain, named str. Cheeloo, derived from infected goats, revealing it has the smallest genome size and fewer gene variations compared to other known species.
- The findings indicate a high infection rate (81.5%) in goats, highlighting str. Cheeloo's significance in the understanding and control of theileriosis, which has resulted in considerable economic losses in animal husbandry.
Rickettsiae are obligate intracellular bacteria that can cause life-threatening illnesses. There is an ongoing debate as to whether established infections by one species preclude the maintenance of the second species in ticks. Here, we identified two species in inoculum from Haemaphysalis montgomeryi ticks and subsequently obtained pure isolates of each species by plaque selection.
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- Pangolins are the most illegally traded wild animals in the world, and scientists are studying them because they may carry diseases like SARS-CoV-2.
- Researchers looked at viruses in 161 pangolins that were smuggled into China and discovered many new types of viruses never seen before in animals.
- Among the findings, scientists identified a coronavirus related to one found in bats, suggesting that pangolins could spread new harmful viruses to humans.
Article Synopsis
- Respiratory syncytial virus (RSV) is an RNA virus that primarily causes severe respiratory illness in children under two, as well as affecting infants and the elderly globally.
- RSV circulates only among humans but was first isolated from chimpanzees; while it can infect some lab animals, it doesn’t naturally spread in them.
- Research discovered that Malayan pangolins have RSV strains closely related to human strains, indicating the possibility of human-to-wildlife transmission of the virus.
Background: The current surveillance system only focuses on notifiable infectious diseases in China. The arrival of the big-data era provides us a chance to elaborate on the full spectrum of infectious diseases.
Methods: In this population-based observational study, we used multiple health-related data extracted from the Shandong Multi-Center Healthcare Big Data Platform from January 2013 to June 2017 to estimate the incidence density and describe the epidemiological characteristics and dynamics of various infectious diseases in a population of 3,987,573 individuals in Shandong province, China.
Persistent SARS-CoV-2 infection in asymptomatic young adults.
Signal Transduct Target Ther
March 2022
An Optimal Nucleic Acid Testing Strategy for COVID-19 during the Spring Festival Travel Rush in Mainland China: A Modelling Study.
Int J Environ Res Public Health
February 2021
Western countries are experiencing surges in COVID-19 cases and deaths due to increasing public transportation during holiday seasons. This study aimed to explore whether mainland China will face an epidemic rebound during the Spring Festival holiday, when millions of Chinese people travel across the country, and investigate which nucleic acid testing (NAT) strategy is optimal to contain the epidemic. A microsimulation model was used to simulate SARS-CoV-2 transmission among railway travelers and evaluated the effects of various NAT strategies.
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