Publications by authors named "Run Cong Nie"
Background: Long noncoding RNAs (lncRNAs) play a critical role in gastric cancer (GC) progression and metastasis. However, research comprehensively exploring tissue-derived lncRNAs for predicting peritoneal recurrence in patients with GC remains limited. This study aims to investigate the transcriptional landscape of lncRNAs in GC with peritoneal metastasis (PM) and to develop an integrated lncRNA-based score to predict peritoneal recurrence in patients with GC after radical gastrectomy.
View Article and Find Full Text PDFBackground: Peritoneal metastasis is the most common metastasis pattern of gastric cancer. Patients with gastric cancer peritoneal metastasis (GCPM) have a poor prognosis and respond poorly to conventional treatments. Recently, immune checkpoint blockade (ICB) has demonstrated favourable efficacy in the treatment of GCPM.
View Article and Find Full Text PDFBased on a subanalysis of the NEOSUMMIT-01 study, it was revealed that perioperative immune checkpoint blockade (ICB) combined with chemotherapy has therapeutic effects in elderly patients with locally advanced gastric cancer, providing a new strategy for the treatment of elderly gastric cancer patients.
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- Tertiary lymphoid structures are groups of immune cells that can affect how cancer turns out, but we don't completely understand how they interact with cancer cells.
- In this study on nasopharyngeal carcinoma, researchers looked at over 343,000 cells to learn more about these interactions and identified important cell types that help fight cancer.
- The findings suggest that certain immune cells help produce antibodies and improve cancer treatments, while others can get tired and stop working well against the cancer.
Article Synopsis
- Chronic exposure to interferon-γ (IFN-γ) in cancers leads to tryptophan shortage via the IDO-kynurenine pathway, which results in abnormal peptides being produced through ribosomal frameshifting and codon reassignment.
- In EBV-positive gastric cancer (GC), infiltrating lymphocytes secrete IFN-γ, increasing IDO1 expression and depleting tryptophan, which promotes the production of tryptophan-to-phenylalanine (W>F) substitutants.
- The mTOR/eIF4E signaling pathway plays a crucial role in this process, as inhibiting it can reduce W>F substitutant production and improve antigen presentation,
Article Synopsis
- Perioperative chemotherapy remains the standard treatment for locally advanced gastric cancer, and a study (NEOSUMMIT-01) is exploring the effectiveness of adding a PD-1 inhibitor called toripalimab to this regimen.
- In the study, patients were randomly assigned to receive either standard chemotherapy or a combination of toripalimab and chemotherapy, with results showing that the latter group had a significantly higher rate of tumor regression (44.4% vs. 20.4%).
- Additionally, the combination treatment led to a greater rate of complete pathological response and had similar rates of surgical complications and treatment-related side effects compared to chemotherapy alone.
Stromal antigen 2 (STAG2), a subunit of the cohesin complex, is recurrently mutated in various tumors. However, the role of STAG2 in DNA repair and its therapeutic implications are largely unknown. Here it is reported that knockout of STAG2 results in increased double-stranded breaks (DSBs) and chromosomal aberrations by reducing homologous recombination (HR) repair, and confers hypersensitivity to inhibitors of ataxia telangiectasia mutated (ATMi), Poly ADP Ribose Polymerase (PARPi), or the combination of both.
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- Circulating tumor DNA (ctDNA) can help doctors understand if stomach cancer might come back after treatment, especially in patients with stage II/III gastric cancer.
- In a study with 100 patients, those who had ctDNA after surgery or chemotherapy had a much higher chance of their cancer returning.
- Using ctDNA measurements along with other tests showed better predictions for cancer recurrence than using just tissue samples alone.
Article Synopsis
- Recent studies on PD-L1 expression in gastric cancer show mixed outcomes, especially regarding patients with peritoneal metastasis.
- Immunohistochemistry was conducted on 147 gastric cancer patients to evaluate PD-L1 expression using a combined positive score (CPS) and analyze its impact on survival.
- Results indicated that higher PD-L1 expression (CPS ≥ 10) was linked to significantly better overall survival compared to lower expression levels, highlighting its potential as a favorable prognostic factor alongside palliative chemotherapy.
Background: Immune-related adverse events (irAEs) are side effects that reflect the activation of patients' immune systems after treatment with immune checkpoint inhibitors (ICIs). However, there is no meta-analysis on the effect of early irAEs on patient survival. Thus, we assessed the association between early irAEs and the survival of patients treated with ICIs.
View Article and Find Full Text PDFBackground: Epstein-Barr virus-associated gastric cancer (EBVaGC) exhibits unique histological characteristics within the immune-cell-rich microenvironment, but the role of tertiary lymphoid structure (TLS) in EBVaGC is not yet fully understood.
Methods: We retrospectively identified EBVaGC from 8517 consecutive GC cases from the two top cancer centers in China. Furthermore, we evaluated the prognostic value of TLS in 148 EBVaGC patients from our institute and then validated it in an external cohort (76 patients).
Background: Although the incidence of adenocarcinoma of the esophagogastric junction (AEG) has been increasing since the past decade, the proportion of AEG cases in two previous clinical trials (ACTS-GC and CLASSIC) that investigated the efficacy of adjuvant chemotherapy was relatively small. Therefore, whether AEG patients can benefit from adjuvant chemotherapy remains unclear.
Methods: Patients who were diagnosed with pathological stage II/III, Siewert II/III AEG, and underwent curative surgery at three high-volume institutions were assessed.
The clinical application of cisplatin is limited by its adverse events, of which nephrotoxicity is the most commonly observed. In a cisplatin-induced pathological response, oxidative stress is one of the upstream reactions which inflicts different degrees of damages to the intracellular material components. Reactive oxygen species (ROS) are also one of the early signaling molecules that subsequently undergo a series of pathological reactions, such as apoptosis and necrosis.
View Article and Find Full Text PDFTo compare the inhibition of LAG3-PD1 versus the inhibition of CTLA-4-PD1 in patients with previously untreated advanced melanoma. The individual participant data (IPD) were extracted from the KM plots using a graphical reconstructive algorithm. Log-rank, Cox proportional hazard model, Bayesian hierarchical model with time-varying hazard ratio (HR) effect, and restricted mean survival time (RMST) were performed to estimate survival benefits.
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- The study investigates the relationship between pyroptosis (a type of cell death) and the tumor immune microenvironment (TIME) in gastric cancer to better understand their interactions.
- Researchers identified distinct groups based on pyroptosis-related characteristics and created a pyroptosis risk score to predict immunotherapy responses and identify potential cancer treatments.
- Findings show that a low pyroptosis risk score correlates with favorable immune cell profiles and better patient outcomes, validating its effectiveness as a prognostic tool for survival and immunotherapy response in gastric cancer.
Background: We aimed to assess whether the Response Evaluation Criteria in Solid Tumors (RECIST)-based objective response rate (ORR), disease control rate (DCR) and progression-free survival (PFS) could serve as surrogate endpoints for overall survival (OS) in immune-oncology (IO) trials of advanced gastro-esophageal (GE) carcinoma.
Methods: Randomized controlled trials (RCTs) of IO that reported RECIST-based endpoints and OS in advanced GE carcinoma were screened. Surrogacy of endpoints for OS was assessed based on the correlation between endpoints with OS (arm-level), and between treatment effects on endpoints (trial-level).
Background: The benefit of adjuvant chemotherapy (AC) for patients with stage II gastric cancer remains controversial. This study aimed to explore the indications for adjuvant chemotherapy in patients with stage II gastric cancer by constructing an individual prediction model.
Patients And Methods: In this Chinese multicenter study, a total of 1012 patients with stage II gastric cancer after D2 radical gastrectomy were retrospectively analyzed.
Background: Circular RNAs (circRNAs) regulate various biological activities and have been shown to play crucial roles in hepatocellular carcinoma (HCC) progression. However, only a few coding circRNAs have been identified in cancers, and their roles in HCC remain elusive. This study aimed to identify coding circRNAs and explore their function in HCC.
View Article and Find Full Text PDFBackground: Serum C-reactive protein (CRP) is a biomarker of an acute inflammatory response and has been successfully used as a prognostic predictor for several malignancies. However, the clinicopathological significance of CRP levels in hepatocellular carcinoma (HCC) patients being treated with PD-1 inhibitors remains unclear.
Methods: Serum CRP levels were measured for a total of 101 HCC patients that had been treated with PD-1 inhibitors from July 2018 to November 2019.
Urachal carcinoma (UrC) is an exceedingly rare tumor and lacks effective treatment. Herein, we characterized an immune microenvironment characteristic of UrC in detail and identified its implications for prognosis and immunotherapy. In total, 37 resections of UrC were stained for CD20, CD3, CD4, CD8, FOXP3, CD68, HLA-DR, CD163, PD1, and PD-L1, as well as mismatch repair protein including MSH2, MSH6, MLH1, and PMS2 by immunohistochemistry.
View Article and Find Full Text PDFBackground: Mismatch repair-deficient (dMMR) or microsatellite instability-high (MSI-H) status serves as a predictor of a poor response to adjuvant chemotherapy among stage 2 colon cancer patients. This study aimed to investigate the efficacy of adjuvant chemotherapy in dMMR/MSI-H gastric cancer (GC).
Methods: Clinical studies comparing adjuvant chemotherapy and surgery alone in dMMR/MSI-H GCs through June 2021 were retrieved to assess the survival of patients managed with both treatments.
Objective: The benefit of adjuvant chemotherapy is still controversial for stage II gastric cancer patients. This study aims to identify prognostic factors to guide individualized treatment for stage II gastric cancer patients.
Methods: We retrospectively reviewed 1121 stage II gastric cancer patients who underwent D2 radical gastrectomy from 2007 to 2017 in the Sixth Affiliated Hospital of Sun Yat-sen University, FuJian Medical School Affiliated Union Hospital and Sun Yat-sen University Cancer Center.