Blocking the TRAIL-DR5 Pathway Reduces Cardiac Ischemia-Reperfusion Injury by Decreasing Neutrophil Infiltration and Neutrophil Extracellular Traps Formation.

Purpose: Acute myocardial infarction (AMI) is a leading cause of mortality. Neutrophils penetrate injured heart tissue during AMI or ischemia-reperfusion (I/R) injury and produce inflammatory factors, chemokines, and extracellular traps that exacerbate heart injury. Inhibition of the TRAIL-DR5 pathway has been demonstrated to alleviate cardiac ischemia-reperfusion injury in a leukocyte-dependent manner.

Modelling women's team line-ups based on effectiveness and quality.

Understanding how different player rotations may impact team performance allows basketball coaches to select effective line-ups for specific tactical scenarios. The study aimed to i) assess how different line-ups or player combinations impact a team's game performance; ii) explore the variations in line-up utilization among different national women's basketball teams; and iii) examine how the offensive efficiency of each line-up evolves during the game. Data from 3,387 ball possessions in 23 international women's basketball games were collected across four major competitions over six years.

Treatment of Ulcerative Colitis by Cationic Liposome Delivered NLRP3 siRNA.

Purpose: The abnormal activation of NLRP3 inflammasome is related to the occurrence and development of ulcerative colitis (UC). However, the ideal drug and delivery system remain important factors limiting the targeting of NLRP3 inflammasome in UC therapy. Gene therapy by delivering siRNA is effective in treating various diseases.

Functional movement screen dataset collected with two Azure Kinect depth sensors.

This paper presents a dataset for vision-based autonomous Functional Movement Screen (FMS) collected from 45 human subjects of different ages (18-59 years old) executing the following movements: deep squat, hurdle step, in-line lunge, shoulder mobility, active straight raise, trunk stability push-up and rotary stability. Specifically, shoulder mobility was performed only once by different subjects, while the other movements were repeated for three episodes each. Each episode was saved as one record and was annotated from 0 to 3 by three FMS experts.

The D-dimer level predicts the prognosis in patients with lung cancer: a systematic review and meta-analysis.

Objective: Although the significance of increased plasma D-dimer levels in activating coagulation and fibrinolysis has been reported, it is still controversial whether it can be used to predict the prognosis of lung cancer patients. This meta-analysis was performed to explore the beneficial role of plasma D-dimer as a prognostic factor in lung cancer patients according to a larger sample capacity.

Materials And Methods: MEDLINE, EMBASE, and Cochrane Central databases were searched from inception to January 2021.

miR-30a-5p suppresses lung squamous cell carcinoma via ATG5 - mediated autophagy.

Unlabelled: Propose: Autophagy plays a complicated role in cancer progression. This study aims at assessing the function of ATG5-induced autophagy in progression of lung squamous cell carcinoma and its upstream mechanism.

Method: TCGA database of lung squamous cell carcinoma was analyzed to explore the differentially expressed miRNAs and mRNAs and relative prognosis.

Antibodies Against Alkaline Protease Directly Enhance Disruption of Neutrophil Extracellular Traps Mediated by This Enzyme.

Extracellular traps released by neutrophils (NETs) are essential for the clearance of . Alkaline protease (AprA) secreted by negatively correlates with clinical improvement. Moreover, anti-AprA in patients with cystic fibrosis (CF) can help identify patients with aggressive forms of chronic infection.

[Progress in Survival Prognosis of Segmentectomy for Early-stage Non-small Cell Lung Cancer].

Surgery is currently the most appropriate treatment for early-stage non-small cell lung cancer (NSCLC). Increasing unilateral or bilateral multiple primary lung cancer being found, segmentectomy has attracted wide attention for its unique advantages in the treatment for such tumors. Ground glass opacity dominant early-stage NSCLC is associated with a good prognosis and can be cured by segmentectomy, however, the treatment of solid-dominant NSCLC remains controversial owing to the invasive nature.

Both the presence of a micropapillary component and the micropapillary predominant subtype predict poor prognosis after lung adenocarcinoma resection: a meta-analysis.

Objective: It has been confirmed that the micropapillary (MP) pattern is a poor prognostic factor after resection of lung adenocarcinoma (ADC), but the proportion of the MP component as a prognostic criterion is still controversial. Hence, a meta-analysis was performed to evaluate whether the presence of an MP component has equal prognostic power as the MP predominant subtype.

Methods: Literature retrieval was performed in the MEDLINE, EMBASE, and Cochrane databases until December 23, 2019.

Soluble uric acid induces myocardial damage through activating the NLRP3 inflammasome.

Uric acid crystal is known to activate the NLRP3 inflammasome and to cause tissue damages, which can result in many diseases, such as gout, chronic renal injury and myocardial damage. Meanwhile, soluble uric acid (sUA), before forming crystals, is also related to these diseases. This study was carried out to investigate whether sUA could also activate NLRP3 inflammasome in cardiomyocytes and to analyse the mechanisms.

Two-Way: A Novel Method for Identifying the Anatomy During Uniportal Thoracoscopic Segmentectomy.

Because the segmental bronchi and vessels are commonly variable and complicated, it is difficult to correctly identify them. Misidentification of the segmental anatomy could result in the failure of segmentectomy and conversion to other surgical procedures such as bisegmentectomy or lobectomy. We describe a novel method to identify the target segmental vessels and bronchi by exposing the adjacent segmental anatomy during uniportal video-assisted thoracoscopic segmentectomy, which could help to reduce the chance of misidentification.

1,25(OH) D alleviates DSS-induced ulcerative colitis via inhibiting NLRP3 inflammasome activation.

1,25-dihydroxyvitamin D3 (1,25(OH) D3, VitD3) is the major active ingredient of vitamin D and has anti-inflammatory activity; however, the mechanism for this remains poorly understood. In this study, we found that VitD3 was able to abolish NOD-like receptor protein 3 (NLRP3) inflammasome activation and subsequently inhibit caspase-1 activation and IL-1β secretion via the vitamin D receptor (VDR). Furthermore, VitD3 specifically prevented NLRP3-mediated apoptosis-associated speck-like protein with a caspase-recruitment domain (ASC) oligomerization.

[Effects of ant colonization on spatiotemporal variation of organic carbon mineralization in Xishuangbanna tropical forest soils].

Ants as ecosystem engineers can increase the input of soil organic matter, change soil physicochemical properties, and stimulate microbial activities through their colonization, thus affecting the spatiotemporal dynamics of soil organic carbon mineralization. We explored the spatiotemporal characteristics of carbon mineralization rates in ant nests and the adjacent soils in Syzygium oblatum community of Xishuangbanna, Yunnan. We analyzed the association of the variation in carbon mineralization rates with soil physicochemical properties.

Meta-analysis of segmentectomy versus lobectomy for radiologically pure solid or solid-dominant stage IA non-small cell lung cancer.

Objective: Whether segmentectomy can be used to treat radiologically determined pure solid or solid-dominant lung cancer remains controversial owing to the invasive pathologic characteristics of these tumors despite their small size. This meta-analysis compared the oncologic outcomes after lobectomy and segmentectomy regarding relapse-free survival (RFS) and overall survival (OS) in patients with radiologically determined pure solid or solid-dominant clinical stage IA non-small cell lung cancer (NSCLC).

Methods: A literature search was performed in the MEDLINE, EMBASE, and Cochrane Central databases for information from the date of database inception to March 2019.

[Effects of ant nesting on soil microbial biomass carbon and quotient in tropical forest of Xishuangbanna.].

Ant nesting can modify soil physicochemical conditions in the tropical forest, exerting a crucial effect on spatiotemporal variation in soil microbial biomass carbon and quotient. In this study, the chloroform fumigation method was used to measure the spatiotemporal dynamics of microbial biomass carbon and quotient in ant nests and the reference soils in Syzygium oblatum community of tropical Xishuangbanna. The results were as following: 1) Microbial biomass carbon and quotient were significantly higher in ant nests (1.

[Effects of ant nesting on the spatiotemporal dynamics of soil easily oxidized organic carbon in Xishuangbanna tropical forests, China].

Ant nesting can form microhabitat and soil nutrient condition in their nests that is diffe-rent from the surrounding environment, thus having a crucial effect on the variation of soil easily oxidized organic carbon (EOC). In this study, the Mallotus paniculatus communities in Menglun Tropical Botanical Garden of Xishuangbanna, Chinese Academy of Sciences was taken as the research object. We compared the spatiotemporal distribution of soil EOC in ant nests and the refe-rence soils, and analyzed the relationship of the variation in soil EOC to the changes in soil physicochemical properties.

Growth differentiation factor 11 ameliorates experimental colitis by inhibiting NLRP3 inflammasome activation.

Growth differentiation factor 11 (GDF11) has an anti-inflammatory effect in the mouse model of atherosclerosis and Alzheimer's disease, but how GDF11 regulates intestinal inflammation during ulcerative colitis (UC) is poorly defined. The Nod-like receptor family pyrin domain-1 containing 3 (NLRP3) inflammasome is closely associated with intestinal inflammation because of its ability to increase IL-1β secretion. Our aim is to determine whether GDF11 has an effect on attenuating experimental colitis in mice.

The contributions of underground-nesting ants to CO emission from tropical forest soils vary with species.

The aboveground ant nests are admitted as hot spots for CO emissions which increase heterogeneity of soil carbon (C) flux in forest ecosystems. However, little is known about effects of underground-nesting ant species on C emissions in tropical forests, where the ants have high diversity and abundance. In this study, we chose three underground-nesting ant species with different feeding-behaviors (Pheidole capellini - predominantly honeydew harvester, Odontoponera transversa - predominantly predator, and Pheidologeton affinis - scavenger) to explore their impacts on soil CO emission in Xishuangbanna tropical forest, China.

Exercise Prevents Upregulation of RyRs-BKCa Coupling in Cerebral Arterial Smooth Muscle Cells From Spontaneously Hypertensive Rats.

Objective: Regular exercise is an effective nonpharmacological means of preventing and controlling hypertension. However, the molecular mechanisms underlying its effects remain undetermined. The hypothesis that hypertension increases the functional coupling of large-conductance Ca(2+)-activated K(+) (BKCa) channels with ryanodine receptors in spontaneously hypertensive rats (SHR) as a compensatory response to an increase in intracellular Ca(2+) concentration in cerebral artery smooth muscle cells was assessed here.