Radiation exposure does not significantly contribute to the risk of recurrence of Chernobyl thyroid cancer.

Context: Papillary thyroid carcinoma (PTC) in patients exposed to environmental radioiodine after the Chernobyl accident is thought to have a relatively aggressive clinical course. Long-term results of treatment are not well known, especially in comparison with sporadic PTC.

Objective: The determination of risk factors for PTC recurrence in a controlled for baseline factors group of patients with radiation-related and sporadic PTC.

[Statistical methods for the analyses in clinical practice. Part 2. Survival analysis and multivariate statistics].

Statistical analysis is an integral component of clinical studies. The objective of the present paper is to assist clinicians in getting deeper insight into basic principles underlying different methods available for the statistical treatment of medical data without a detailed description of relevant mathematical calculations. The most popular and widely used methods of statistical analysis are considered with special reference to their practical application in clinical and experimental medicine.

[Statistical methods for the analyses in clinical practice. Part 1. Univariate statistical analysis].

Statistical analysis is an integral component of any clinical study. The objective of the present work was to assist clinicians in understanding various methods of statistical treatment of medical findings without going into details of mathematical computation. The most strongly sought for and popular analytical procedures are considered in application to clinical and experimental medical research.

[Diagnosis and treatment policy in familial thyroid cancer].

Thirty-two cases of hereditary medullary thyroid carcinoma (HMTC) and 95 sporadic HMTC (SHMTC), 44 familial papillary TC (FPTC), and 172 sporadic cases were comparatively analyzed to improve the diagnosis and treatment of familial thyroid cancer. A hundred and one DNA samples from patients with MTC and their relatives were examined. BRAF and RET/PTC gene mutations were investigated in 6 patients with FPTC.

[The diagnosis and treatment of hereditary forms of medullary carcinoma of the thyroid: Clinical and genetic aspects].

Medullary thyroid cancer (MTC) is a fairly rare disease, accounting for 5-7% of all cases of thyroid cancer. The sporadic form of thyroid cancer is observed in 70-80% of cases, family (inherited - autosomal dominant type of inheritance) - in 20-30%. Familial forms of MTCG are caused by point mutations in the RET proto-oncogen (Rearranged during Transfection).