Efficacy of a retinoid complex plus anti-inflammatory component cream alone or in combination with prebiotic food supplement in adult acne: A randomized, assessor-blinded, parallel-group, multicenter trial on 184 women.

Background: Adult female acne (AFA) nowadays is a very common skin condition affecting mainly women aged between 25 and 40. The treatment of AFA could be challenging.

Study Aim: We evaluate and compare the efficacy and tolerability of a cream formulation containing two retinoid molecules (hydroxypinacolone/retinyl palmitate) combined with Iris Florentina root extract and a complex of three oligopeptides (C) applied twice a day (morning and evening) alone or in combination (C + O) with a food supplement containing a mixture of prebiotic molecules (FOS&GOS) zinc, lactoferrin, and niacinamide.

Cation-anion interaction effect on the nonlinear optical behavior of pyridinium-based ionic liquids.

Influence of the cation-anion interaction (expressed as internal hydrogen bonds) on the nonlinear optical properties (dipole moment, polarizability, anisotropy of polarizability and first-order hyperpolarizability) for the ionic liquids pyridinium hydrogen sulfate (PHS) and pyridinium bis(dihydrogen phosphate) (P2HP) was investigated in this paper. It was achieved analyzing vibrational modes (FT-IR) and electronic transitions (UV-vis) in PHS and P2HP. Molecular geometry of the title compounds was optimized by means of density functional theory calculations at B3LYP/6-311++G(2d,2p) level.

A combined DFT and FT-IR study on the surface interactions in alumina supported ionic liquid [H-Pyr][HSO].

The surface interactions in [H-Pyr][HSO]/γ-AlO system (prepared by wetness impregnation method) are investigated theoretically and experimentally. For that purpose, atoms in molecules theory, natural bond orbital and natural charge population analyses in a combination with a vibrational spectroscopy (FT-IR) are used. It is established that a bond formation between the hydrogen sulfate anion and the alumina influences the IL-support interaction in a great extent.

Mechanistic investigation of molecular geometry, intermolecular interactions and spectroscopic properties of pyridinium nitrate.

The molecular structure, vibrational frequencies of the fundamental modes and electronic transitions of the ionic liquid pyridinium nitrate ([H-Pyr][NO]) have been determined by means of density functional theory (DFT) at B3LYP/6-311++G (2d,2p) level. The chemical bonds nature and the intermolecular interactions in the title compound were investigated using the Quantum theory of atoms in molecules and Hirshfeld surface analysis. Natural bond orbital analysis has been performed in order to elucidate the hybridization and delocalization of electron density within the ion pair [H-Pyr][NO].

Association between Type 2 Diabetes, Obesity and Key Immunological Components of IgE-mediated Inflammation.

Background: Changes in lifestyle and obesity in recent decades have brought about a dramatic increase in type 2 diabetes mellitus (DM2) and allergic diseases. Clinical and epidemiological studies associate obesity with epidemics of allergic diseases. The link between obesity and DM2 with immunological components of IgE-mediated allergic inflammation is not yet conclusively established.

Treatment of Plaque-Type Psoriasis With Oral CF101: Data from a Phase II/III Multicenter, Randomized, Controlled Trial.

Background: CF101, an adenosine A3 receptor agonist, is an orally bioavailable small molecule drug presenting an anti-psoriatic effect demonstrated in a Phase 2 clinical trial in psoriasis patients.


Objective: To evaluate the safety and efficacy of CF101 treatment in a Phase 2/3 study in patients with moderate to severe plaque-type psoriasis.


Methods: This multicenter, double-blind, 2-segment, placebo-controlled study randomized subjects with moderate to severe plaque psoriasis to CF101 1 or 2 mg, or placebo twice daily.

Cutaneous Mastocytosis with Persistent Blistering: Successful Treatment with Methylprednisolone and 3-Year Follow-Up Management.

Background: Mastocytosis is a rare disorder with diverse clinical manifestations. In cutaneous mastocytosis the mast cell infiltration is limited to the skin, but is often associated with systemic symptoms due to the release of mast cell mediators.

Case Report: We report a 6-month-old male infant who had skin lesions of various morphologies (macules, papules, plaques, and nodules) and sizes, persistent blistering and frequent flushing episodes for half a year.