Evaluation of the treatment strategy for complicated allergic rhinitis.

Objective: Aim: To carry out a comprehensive evaluation of treatment modification for patients with seasonal allergic rhinitis (SAR) complicated by anxiety-neurotic disorders.

Patients And Methods: Materials and Methods: Patients with SAR in the acute stage on the background of anxiety disorders were studied. Immunological studies were carried out, an assessment of the dynamics of indicators of the quality of life of patients, the level of anxiety / depression was assessed.

NEUROMETABOLIC STRATEGY OF PHARMACOTHERAPY FOR PATIENTS WITH SERONEGATIVE ARTHRITIS.

Objective: The aim: The search for optimization of the strategy of neurometabolic pharmacotherapy in patients with seronegative arthritis is relevant: ankylosing spondylitis and psoriatic arthritis, taking into account the nature of the psychological response to the disease.

Patients And Methods: Materials and methods: The study included (1st observation group) 36 patients with AS (17 men and 19 women) aged 25 to 65 years, average duration of AS - 10.9 ± 0.

CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND COMORBIDITIES: MANAGEMENT OF SOMATOFORM DISORDERS.

Objective: The aim: To perform a comprehensive evaluation of the effect of paroxetine on the degree of somatoform disorders in exacerbation of severe COPD in women.

Patients And Methods: Materials and methods: The study involved 53 female patients with severe COPD (Group D), confirmed by instrumental methods of study. At hospitalization, patients were divided into 2 groups.

[ITS-polymorphism of salt-tolerant and salt-sensitive native isolates of Sinorhizoblum meliloti--symbionts of alfalfa, clover and fenugreek plants].

Polymorphism of rrs-rrl sequence of ribosomal operons (intergenic sequence, ITS) was studied among 81 isolates of Sinorhizobium meliloti (AK001-AK210) derived from the collection of alfalfa nodulating bacteria of the Laboratory of genetics of ARRIAM, by using species-specific primers FGPS 1490/FGPL132VM. Isolates were obtained from nodules of different species of wild host plants from Medicago, Melilotus and Trigonella genera grown in salinized North-Western region of Kazakhstan. The typical structure of ITS, similar to that of test strain Rm1021, was dominant in native rhizobia population, while in one third of the isolates (33.

[The universal audiological screening of newborn infants: achievements and challenges].

The objective of the present study was to estimate the effectiveness of universal audiological screening of newborn infants in Russia based on the results of this procedure obtained in 2011-2012 by the analysis of the activities of surdological centres in 15 regions of the country. It was shown, that the main indicators of the effectiveness of the screening are the technical equipment of maternity houses, newborn coverage at the first stage of screening, and its continuity. The study revealed 3.

[Genetic resources of nodule bacteria].

Nodule bacteria (rhizobia) form highly specific symbiosis with leguminous plants. The efficiency of accumulation of biological nitrogen depends on molecular-genetic interaction between the host plant and rhizobia. Genetic characteristics of microsymbiotic strains are crucial in developing highly productive and stress-resistant symbiotic pairs: rhizobium strain-host plant cultivar (species).

[Dyslexia: clinical, neurophysiological and neuropsychological manifestations during the treatment with nootropil].

Forty children with dyslexia, aged 7-12 years, have been randomized into two groups in an open controlled study: 18 of them received Nootropil (piracetam) in the dose of 100 mg/kg daily for 2 months and 22 were examined as a control group. Nootropil exerted positive effects on reading and spelling skills in 56% of children with dyslexia who demonstrated the improvement of fluency and accuracy of reading along with a significant decrease of specific errors (dysphonemic and visuospatial) in dictation. In the control group, the improvement was seen only in 10% of children.

[Symbiosis between the nodule bacterium Sinorhizobium meliloti and alfalfa (Medicago sativa) under salinization conditions].

Two hundred forty-three isolates of alfalfa nodule bacteria (Sinorhizobium meliloti) were obtained from legume nodules and soils sampled in the northern Aral region, experiencing secondary salinization. Isolates obtained from nodules (N isolates) were significantly more salt-tolerant than those from soils (S isolates) when grown in a liquid medium with 3.5% NaCl.

[Instability of a cryptic plasmid in Sinorhizobium meliloti P108 during symbiosis of it with alfalfa Medicago sativa].

Instability of cryptic plasmids in Sinorhizobium meliloti laboratory strains SKhM1-188, DM7-R, and P108 as well as in their clones isolated from nodules of alfalfa grown during a long-term microvegetation experiment (120 days) was studied. The isolated clones of strains SKhM1-188 and DM7-R manifested stable inheritance of plasmids, whereas 12.7-14.

[Hearing disorders in children: epidemiological evidence].

The data of surdological regional services served the basis for a comparative epidemiological analysis of hearing disorders in children. The analysis of the data showed that systemic mass check-ups of children is effective for prevention of hypoacusis. It is recommended to follow-up children with insignificant and unilateral hearing loss.

[The use of instenon in children with minimal brain dysfunction].

Minimal brain dysfunction (MBD) represents the most common type of neuropsychic disorders in childhood. Resulting in focal damages, underdevelopment and dysfunction of one or another cortical regions of brain hemispheres, MBD manifested in children as movement and speech disorders, dysgraphy, dyslexia, dyscalculia and attention deficit hyperactivity disorder. In the open controlled study, an efficacy of the complex nootropic medication "Instenon" was evaluated in the treatment of 59 MBD patients, aged 4-12 years.

[Genetic diversity of a natural population of Sinorhizobium meliloti, detected during analysis of a cryptic plasmid and ISRm2011-2 fingerprints].

Fifty-six natural strains of alfalfa nodule bacteria were isolated from samples of the soil under wild legume and alfalfa in two different field sites of Irkutsk oblast. Based on the results of analysis of plasmid profile, 11 different types of strains were detected, and 43 types were identified based on the results of hybridization with the insertion sequence element ISRm2011-2. Significant differences were found in the plasmid profile and IS fingerprints between strains isolated from the soil under alfalfa and the soil under legume.

[Analysis of plasmids in Rhizobium meliloti strains of different geographical origin].

The presence of 1-3 additional plasmids ranging from 16 to 400 Md in mol mass was revealed in bacterial cells besides a megaloplasmid in most of 34 Rhizobium meliloti strains studied. No correlation was found between plasmids pattern and geographical origin of isolation source of the strain analyzed.

[Heterogeneity of agglutinability and antibiotic sensitivity of a population of Staphylococcus aureus isolated from tonsillar lacunae of patients with angina and chronic tonsillitis].

The study of the staphylococcal microflora of the tonsils in chronic tonsillitis patients revealed a high degree of variability in respect to its sensitivity to different antibiotics and the level of its agglutination by blood serum. The lesser part of the patients showed the presence of staphylococcal clones agglutinated by highly diluted serum and resistant to antibiotics suppressing the main part of the microbial population. The appearance of such clones in the microbial population is supposed to be the reason for the development of antibiotic-resistant population.